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The World Health Organization published a report entitled Blood Donor Selection: Guidelines on Assessing Donor Suitability for Blood Donation. Based on a review of scientific studies and other literature, it contains detailed recommendations for establishing blood donation programs, including which donors to accept or reject. It mentions several autoimmune ...


7

Is there any truth behind chemotherapy actually curing Multiple Sclerosis? Unfortunately, no. Multiple sclerosis (MS) is a chronic illness - meaning that it cannot be completely cured. There are, however, various therapeutic options for patients suffering from MS. Some of them include chemotherapeutics - but not as the first-line treatment. The important ...


7

I am answering this almost two years after it was asked, but I hope an answer can still be useful! Hashimoto’s Disease You are correct that Hashimoto’s disease (also known as Hashimoto’s thyroiditis) is the most common cause of hypothyroidism in those aged over six. In younger children hypothyroidism is most often congenital. So yes, you almost certainly ...


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Your question is difficult to answer (but still interesting) because lupus is a highly heterogeneous condition which can present various symptoms and organ involvement. Choice of therapy will be tailored on the patient symptoms and his disease activity and severity. Here a broad overview of the current management strategies of lupus: The most frequent used ...


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Eczema (atopic dermatitis) Atopic dermatitis is a chronic, itchy skin condition that is very common in children but may occur at any age. It is also known as eczema and atopic eczema and was formerly known as Besnier prurigo. It is the most common form of dermatitis. Pathophysiology The pathophysiology of atopic dermatitis is complex and ...


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Studies have shown that arthritis (joint inflammation) and arthralgias (joint pain) are reported in up to 95 percent of patients with systemic lupus erythematosus (SLE). There is currently no evidence for the use of collagen supplements in lupus patients. Actually, some decades ago, these supplements have been suggested in patients with osteoarthritis. The ...


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I'm not aware of any work done in this area. A whole blood transfusion is not going replace circulating defective lymphocytes. On the other hand Hematopoietic Stem Cell Transplantation has some promise in patients with deteriorating lung function. Autologous HSCT could “reset” the host immune system to a point in time when the antigenic triggers of ...


5

Steroids are used as treatment for acute attacks/flares in many diseases because they reduce inflammation. In multiple sclerosis, they are given to reduce inflammation of the nerves that occurs when the immune system attacks the nervous system. This inflammation may be one mechanism that causes the nerve damage in multiple sclerosis, although this seems to ...


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Yes, there is statistically significant comorbidity with autoimmune diseases. The study Recent Insights in the Epidemiology of Autoimmune Diseases: Improved Prevalence Estimates and Understanding of Clustering of Diseases analysed other studies on the subject. It puts the comorbidity of 29 autoimmune diseases - including, for example, Crohn's, diabetes, ...


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There are several reasons why we can't specify the range here on Health SE, especially for anti-TPO Ab. The test method Antibodies are proteins, produced by our immune system. Determining the concentration of a specific protein is somewhat more difficult than determining the concentration of a smaller molecule. Still, there are various methods for this - ...


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Advanced Glycation End-products These are basically proteins and lipids that are glycated in a high glucose environment, e.g. in untreated diabetic patients. Wikipedia has an article about the details. In case you need more details than Wikipedia provides: you can find numerous peer reviewed articles via Pubmed, this one for example was suggested by user ...


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Although serum levels of the acute‐phase reactant C‐reactive protein (CRP) usually parallel disease activity in inflammatory states, it is widely believed that systemic lupus erythematosus (SLE) is an exception. https://onlinelibrary.wiley.com/doi/full/10.1002/art.24316. Well, since it is an exception we cannot say CRP levels are not reliable indicators of ...


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Very interesting question. Thank you. The pathophysiology of photosensibility in lupus patients is related to the effect of ultraviolet radiation (UVR) on cells of the immune system. UVR stimulates lymphocytes recruitment and antibody-mediated cytotoxicity, which are involved in the pathogenesis of lupus. The mechanisms by which ultraviolet-A (UVA) (320–...


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I answered a similar question (Is autism caused by genetics?) on Psychology & Neuroscience where the following was found, plus I have added information regarding autoimmune responses concerning Autism. Autism spectrum disorder (ASD) now affects one in 68 births in the United States and is the fastest growing neurodevelopmental disability worldwide (...


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Autoimmunity triggered by vaccination is a documented, but rare occurrence. The current research shows a correlation between autoimmune conditions and elevated levels of HLA proteins. Certain HLA proteins tend to have a predilection for activating the immune system against “self” cells. HLA proteins also can explain why certain people are more prone to ...


3

I will discuss azathioprine here, as there are many different immunosuppressant drugs that work in different ways. The immune system is a complex thing and most will inhibit only one particular aspect of it. Azathioprine Azathioprine is an immunosuppressant drug. It has been around for a long time but is still widely used. Unlike certain modern drugs that ...


3

Even if the CLO test comes up negative on the biopsy, you could have your blood tested to see if you are sera positive for H. pylori. This would show if you've ever been exposed rather than have an ongoing infection in the polyp. This may not be medically significant, however, because it would not show active infection and a need for antibiotics. ...


2

Odds vary. The most straightforward study I could find was Koumantaki et al. (1997), which found several odds ratios for developing rheumatoid arthritis: 4.4 for individuals having a first degree relative with the disease. 5.4 for individuals having a female first degree relative with the disease. 7.0 for females having a first degree relative with the ...


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Medicine, more than almost any other discipline, requires continuing education through the entire career. It changes rapidly, and whatever a doctor was taught 20 years ago in med school, or even 10 years ago at a conference, may not be true today. So if they're not keeping up, they're going to be ignorant on some issues. I've seen that myself more than once ...


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Like many health issues that are currently on the rise, anything you can potentially say is vaccine related can also easily be said to be environmental toxin related. There is quite a bit of research on autoimmune issues as it's currently a serious cause for concern to many researchers. It is much more common today than it was 50 years ago and they are ...


2

No, not all type II Hypersensitivities are autoimmune diseases. Example: blood transfusion reactions, erythroblastosis fetalis, are also type 2.. but these are not autoimmune. Type 2 indicates reaction between antigen and antibodies.. Auto-immune means antibody acting against own body cells.. That's why all type 2 is not autoimmune.. Source: https://en....


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Like everything else, we're instructed by past experiences. Although there weren't a lot of data on neurologic aspects of MERS and SARS, there were some papers describing neurologic complications in those patients. In rare cases, complications including ADEM (acute disseminated encephalomyelitis)-like demyelination, encephalitis, and brainstem encephalitis ...


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I have a auto immune inflammatory arthritis and Vietnam time my crp was elevated was xinhua chest infection. They measure my c3 and c 4 which are elected and I'm Told more accurate markers.


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This type of data can only come from studies. The ones I've looked at so far do not indicate that single organ autoimmune disease is a risk factor. The risk factors they looked at in the study below were: age, smoking, cardiorespiratory disease, hypertension, cerebrovascular disease, chronic renal disease, immunodeficiency, hepatitis B infection, diabetes (...


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In treatment of rheumatoid arthritis, the following immunosuppressants, which are already in use, inhibit cytokines: Non-biologic DMARDs (Disease-modifying antirheumatic drugs): methotrexate, leflunomide, hydroxychloroquine, sulfasalazine, cyclosporine, and tacrolimus Biologic DMARDs: adalimubab, anakinra, certolizumab, etanercept, golimubab, infliximab, ...


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Many conditions can lead to fetal hydrops. The most significant contributing factor is the fetal homeostatic response to relative hypoxia. For a number of reasons, the fetus is more prone to the acccumulation of interstitial fluid. This can be triggered by hypoxia as the fetal circulation responds in an attempt to maintain oxygenation of the tissues. From ...


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Women are actually treated with hormones, just ones that aren't estrogen/progesterone/ect.. People with severe RA are treated with glucocorticoids in order to decrease T and B cell proliferation that further damage to the synovial joints. These hormones have long term health impacts (such as Cushing's disease) and should be used as a last ditch effort. ...


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