8 votes
Accepted

How does a thymus transplantation work? Why doesn't it result in rejection of the recipient's... everything?

In the original New England Journal of Medicine paper (Markert et al 1999. PMID 10523153), the authors demonstrate that following transplantation, the donor thymus contains recipient T-cells. the use ...
Ian Campbell's user avatar
  • 3,256
7 votes
Accepted

Knowing the root cause of one's hypothyroidism? How to know if it's Hashimotos Disease?

I am answering this almost two years after it was asked, but I hope an answer can still be useful! Hashimoto’s Disease You are correct that Hashimoto’s disease (also known as Hashimoto’s thyroiditis)...
Chris's user avatar
  • 3,332
7 votes
Accepted

Multiple Sclerosis and Chemotherapy

Is there any truth behind chemotherapy actually curing Multiple Sclerosis? Unfortunately, no. Multiple sclerosis (MS) is a chronic illness - meaning that it cannot be completely cured. There are, ...
Lucky's user avatar
  • 2,833
7 votes
Accepted

Top medications to treat symptoms of Lupus?

Your question is difficult to answer (but still interesting) because lupus is a highly heterogeneous condition which can present various symptoms and organ involvement. Choice of therapy will be ...
M. Arrowsmith's user avatar
6 votes

What is the difference between eczema and urticaria?

Eczema (atopic dermatitis) Atopic dermatitis is a chronic, itchy skin condition that is very common in children but may occur at any age. It is also known as eczema and atopic eczema and was ...
Chris's user avatar
  • 3,332
6 votes
Accepted

Do collagen supplements help ease some of the symtoms of Lupus?

Studies have shown that arthritis (joint inflammation) and arthralgias (joint pain) are reported in up to 95 percent of patients with systemic lupus erythematosus (SLE). There is currently no ...
M. Arrowsmith's user avatar
6 votes
Accepted

Is it possible to have an autoimmune disease and no C-reactive protein in blood serum?

Although serum levels of the acute‐phase reactant C‐reactive protein (CRP) usually parallel disease activity in inflammatory states, it is widely believed that systemic lupus erythematosus (SLE) is an ...
Sikander's user avatar
  • 311
5 votes
Accepted

"AGE" meaning in the term AGE-associated autoantibodies?

Advanced Glycation End-products These are basically proteins and lipids that are glycated in a high glucose environment, e.g. in untreated diabetic patients. Wikipedia has an article about the ...
Arsak's user avatar
  • 323
5 votes
Accepted

How is sunlight a Lupus trigger for some? What exactly about the sun often causes Lupus flare-ups?

Very interesting question. Thank you. The pathophysiology of photosensibility in lupus patients is related to the effect of ultraviolet radiation (UVR) on cells of the immune system. UVR stimulates ...
M. Arrowsmith's user avatar
5 votes

Can blood transfusion help in case of scleroderma?

I'm not aware of any work done in this area. A whole blood transfusion is not going replace circulating defective lymphocytes. On the other hand Hematopoietic Stem Cell Transplantation has some ...
Graham Chiu's user avatar
  • 13.3k
5 votes

Vaccines and autoimmunity concerns

Autoimmunity triggered by vaccination is a documented, but rare occurrence. The current research shows a correlation between autoimmune conditions and elevated levels of HLA proteins. Certain HLA ...
Mike-DHSc's user avatar
  • 1,109
4 votes
Accepted

Why do some General Practioners not consider Fibromyalgia as a genuine, real auto-immune disorder?

Medicine, more than almost any other discipline, requires continuing education through the entire career. It changes rapidly, and whatever a doctor was taught 20 years ago in med school, or even 10 ...
Carey Gregory's user avatar
  • 9,862
4 votes
Accepted

How does immunosuppressant affect immune system?

I will discuss azathioprine here, as there are many different immunosuppressant drugs that work in different ways. The immune system is a complex thing and most will inhibit only one particular aspect ...
Chris's user avatar
  • 3,332
4 votes
Accepted

Is autism an autoimmune disease?

I answered a similar question (Is autism caused by genetics?) on Psychology & Neuroscience where the following was found, plus I have added information regarding autoimmune responses concerning ...
Chris Rogers's user avatar
  • 6,185
4 votes
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Can autoantibodies found in the father affect the embryo, and how?

I think you're right to be stumped. The text you're referring to discusses Fig. 3C in the review; they note it's preliminary data but also seem to use strange/wrong descriptions, e.g. in the Fig 3 ...
Armand's user avatar
  • 992
3 votes
Accepted

Does Coriander Seed increase or decrease tnf alpha and il-6?

Both of these studies involve a rodent inflammation model where complete freund's adjuvant is injected to incite inflammation, and then rats are given an alcohol-based coriander seed extract or other ...
Bryan Krause's user avatar
  • 14.1k
2 votes

Vaccines and autoimmunity concerns

Like many health issues that are currently on the rise, anything you can potentially say is vaccine related can also easily be said to be environmental toxin related. There is quite a bit of research ...
threetimes's user avatar
2 votes
Accepted

Can SARS-CoV-2 be a potential cause for Guillain-Barré syndrome?

Like everything else, we're instructed by past experiences. Although there weren't a lot of data on neurologic aspects of MERS and SARS, there were some papers describing neurologic complications in ...
Graham Chiu's user avatar
  • 13.3k
2 votes
Accepted

Are type 2 hypersensitivities autoimmune diseases?

No, not all type II Hypersensitivities are autoimmune diseases. Example: blood transfusion reactions, erythroblastosis fetalis, are also type 2.. but these are not autoimmune. Type 2 indicates ...
Sird's user avatar
  • 36
2 votes
Accepted

If we could remove all auto-antibodies would the auto-immune disease get cured?

Yes, there actually is a correct answer to this: not every autoimmune disease is antibody driven. Take coeliac disease: antibodies are just an epiphenomenon of the immune process, which is actually ...
Cherenkov's user avatar
2 votes

What are the risks associated with imidazoquinoline adjuvant (used in one Covid-19 vaccine) related to development of autoimmune diseases?

I will try to summarize what I have gathered till now from reading on my own and insights from other people. In the study 1 that I have cited, they have found that on mice, a dose of 100 micrograms of ...
Prem's user avatar
  • 41
2 votes

what is the mechanism through which TLR 7 agonist causes autoimmune disease?

There is a subtype of lupus called Drug induced lupus (DIL), as the name says certain drugs cause the signs and symptoms of lupus in susceptible individuals. The difference between DIL and normal ...
Bashi's user avatar
  • 156
1 vote
Accepted

What are the pathologies most likely to occur after leukemia?

Generally in leukemia patients there are long term complications related to the treatments given including the usually curative treatment called "Allogenic hematopoietic stem cell transplantation&...
Bashi's user avatar
  • 156
1 vote

Why is multiple sclerosis associated with trigeminal neuralgia?

The reason for that association is not known. Neither etiology of these two diseases is undiscussed. Arguably, neighbouring veins exerting pressure on the trigeminal nerve cause trigeminal neuralgia....
Peter Bernhard's user avatar
1 vote

Is a patient who has an autoimmune disease immunocompromised?

This type of data can only come from studies. The ones I've looked at so far do not indicate that single organ autoimmune disease is a risk factor. The risk factors they looked at in the study below ...
Graham Chiu's user avatar
  • 13.3k
1 vote
Accepted

Can we slow the advancement of Rheumatoid Arthritis (RA) with immunosuppressants?

In treatment of rheumatoid arthritis, the following immunosuppressants, which are already in use, inhibit cytokines: Non-biologic DMARDs (Disease-modifying antirheumatic drugs): methotrexate, ...
Jan's user avatar
  • 15.9k
1 vote
Accepted

Why does hydrops fetalis occur in erythroblastosis fetalis?

Many conditions can lead to fetal hydrops. The most significant contributing factor is the fetal homeostatic response to relative hypoxia. For a number of reasons, the fetus is more prone to the ...
Chris's user avatar
  • 3,332
1 vote

How does interferon beta 1-A help patients with multiple sclerosis?

Your question alludes to a paradox: "azathioprine weakens the immune system ..." "interferons boost the immune system ... They seem to have different functions, but they treat the same ...
Peter Bernhard's user avatar
1 vote
Accepted

Rheumatoid arthritis and hormones

Women are actually treated with hormones, just ones that aren't estrogen/progesterone/ect.. People with severe RA are treated with glucocorticoids in order to decrease T and B cell proliferation that ...
rocc's user avatar
  • 156

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