4

Both of these studies involve a rodent inflammation model where complete freund's adjuvant is injected to incite inflammation, and then rats are given an alcohol-based coriander seed extract or other injections. These are pretty low-quality papers in low-quality journals. I'll start with the one you link second: Deepa, B., Acharya, S., & Holla, R. (2020)...


3

I think you're right to be stumped. The text you're referring to discusses Fig. 3C in the review; they note it's preliminary data but also seem to use strange/wrong descriptions, e.g. in the Fig 3 caption: "The presence of maternal FRα antibodies or presence of antibodies in both parents will negatively affect the treatment outcome." I think ...


2

Yes, there actually is a correct answer to this: not every autoimmune disease is antibody driven. Take coeliac disease: antibodies are just an epiphenomenon of the immune process, which is actually cell-mediated (Medscape). Thinking about the pathophysiology of certain autoimmune diseases should help in understanding this: something goes wrong in the antigen ...


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