Studies have shown a significant reduction of Vitamin B12 levels in individuals with vitiligo. This meta-analysis provides an overview: https://pubmed.ncbi.nlm.nih.gov/30165163/

Results: Twenty-two studies involving a total of 1448 patients with vitiligo were included. Patients with vitiligo had significantly higher serum homocysteine levels (standardized mean difference [SMD] 0.550, 95% confidence interval [CI] 0.262-0.838; I2 87.3%) and lower vitamin B12 levels (SMD -0.430, 95% CI -0.738 to -0.121; I2 85.3%) than controls. Serum folate levels were not significantly different between the 2 groups (SMD -0.240, 95% CI -0.592 to 0.111; I2 85.5%). A subgroup analysis revealed that these findings correlated with disease activity.

Given that Vitamin B12 is primarily found in animal-based foods such as meat, poultry, fish, eggs, and dairy, I was curious if there is a relationship between a vegan diet and the prevalence or progression of vitiligo.

  • I am in no position to answer your question, but I have referred it to my sister who has vitiligo. I am looking into the link between Vitamin B12 deficiency and how the symptoms can sometimes be misdiagnosed as dementia with devastating consequences.
    – Lesley
    Commented May 8, 2023 at 10:32


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