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I read an article here that says:

“There is a very strong correlation between consuming dairy products — such as milk — and acne, skin breakouts and aging.”

The reason? Hormones, Bella says. “Most of the cows used in farming are actually pregnant cows. The hormones such as progesterone and insulin growth factors make their way into the milk,” she explains. “When we consume the milk, it leads to increased levels of inflammation, skin breakdown, aging and acne in many people.”

It was interesting for me to ask: Can those hormones be alive(active) even when we eat pasteurized milk(boiled milk) and other dairies that I think are derived from the pasteurized milk?

I mean won't hormones destroyed after boiling milk? I also like to know can cow hormones have any effects on humans?

  • Many mammals have identical or nearly identical hormones. One way to look at a hormone that might help illuminate this is as "a vitamin the body can synthesize". Many mammals synthesize vitamin c, but in them it is a hormone. Humans can synthesize vitamin d, so it's actually a misnomer. In medicine, many prescribed hormones are derived from pigs and horses. Short answer, if they are intact they usually greatly affect the human body. So called "bio-identical" hormones are preferred by some physicians because they lack some of the unique side effects of nearly identical, animal derived hormones. – fredsbend Feb 3 at 22:54
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These are biologically plausible effects supported by moderate quality observational evidence. As a personal aside, I do not believe there is enough evidence for harm to recommend eliminating dairy products from a healthy person's diet. A full discussion of all the evidence for the impact of dairy in diet is beyond the scope of this answer, though, so lets move on to your specific question

Sex steroids are lipid soluble fused ring structures derived from cholesterol, and conserved across many species. They are not inactivated by pasteurization. In addition to being identified in dairy products and in the people who consume them, consumption of dairy products appears to be associated with some expected biological effects in humans, e.g., sperm quality. That linked study as well as the other points are succinctly reviewed in the introduction to this article.

Insulin like growth factor 1 (IGF-1) is a peptide hormone, but has been demonstrated to be active after pasteurization. It is also conserved across species. There is evidence (well summarized in both the narrative review and meta-analysis in this article) for an association between consumption of dairy products, increased levels of circulating IGF-1, and downstream effects of that increased level (e.g., prostate cancer).

You should note that it is not surprising that a hormone produced by another animal would be active in a human. See, the 1923 Nobel Prize.

Just to be clear: This answer addresses the specific two questions posed in the OP: are hormones in milk and milk products active after pasteurization, and are cow hormones active in humans. This answer (and the evidence) does NOT provide support for the question, in balance is dairy good or bad for you, and does not address the claims in the linked article (a la a Skeptics.SE question)

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    No. This is all tangential reasoning on theoretical levels. Could you address more of this nonsense: “Most of the cows used in farming are actually pregnant cows." Coz, yes, cows are very often pregnant, but, if this is about milk… The reasoning in OPQ is some vegan conflation of things. – LangLangC Feb 1 at 16:09
  • @LangLangC the question asks if hormones can be active after pasteurization, and if cow hormones can have an effect on humans. I think I answered that clearly with direct non tangential evidence. Can you clarify how my answer is tangential to that question? Re the health implications and the relationship to decision making, I think I was also clear that this is not sufficient evidence to not drink milk, despite that not being the question. If you have a question about whether most cows are pregnant, you could ask that. It would probably be best in a different stack. – De Novo Feb 1 at 16:33
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    @LangLangC a (political) knee jerk reaction against moderate quality observational evidence is not helpful. The politics of the huffington post article may be questionable, but it doesn't help to say NO to the evidence. It is what it is, and it is NOT a reason not to drink milk, as I clearly stated. I happen to think dairy is good for you, and incorporate it in my and my family's diet. The overall health effect of dairy is, however, beyond the scope of this question. – De Novo Feb 1 at 16:55
  • @LangLangC I will, though, anecdotally answer your pregnancy question, having grown up on a farm and in a farming community, I happen to have some experience there. Yes, large scale dairies milk pregnant cows. Some small family farms avoid it, because, as with humans, chain pregnancies (getting pregnant again before fully recovering from the prior pregnancy) can be stressful for the cows and they actually don't produce as much milk when pregnant. Lactation, as you are aware, is something that typically happens after pregnancy, – De Novo Feb 1 at 17:05
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    @LangLangC I think the issue here is that I'm answering the specific questions posed by the OP, and you're looking for someone to address the article linked to and quoted in the question. If you want to add an answer that more generally discusses the arguments in the article that milk causes aging, acne, I think that would be helpful. I tried to stay away from the vegan politics and address what sounded like a scientific misunderstanding on the part of the OP (hormones are species specific and can't survive pasteurization). – De Novo Feb 1 at 17:17
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If the main thrust of the question is indeed expressed in the title and tags of the question:

Q “There is a very strong correlation between consuming dairy products — such as milk — and acne, skin breakouts and aging.”

Then the jury on that really isn't finished deciding:

Is acne related to the ingestion of dairy products? It is not a new idea. It goes back to the early days of the last century and beyond. The counter-claim, that there is no relationship between diet and acne, has reached mythic proportions. It has never been substantiated, but it is repeated as gospel in all major dermatology textbooks. Epstein, commenting on contributions on the subject by Waisman, Bickers, and Rosenberg, trod the middle road. Inexplicably asserting that "Controlled studies indicate that foods have no effect on acne," he nonetheless allowed, "the patient should receive any assistance that dietary control may impart." In a review of 274 clinical trials of acne, the massive 2001 Evidence Report on the Management of Acne found one solitary paper that mentioned diet, but no trial reported specifically on patients’ diets.

Dairy products have been implicated as a possible factor in the etiology of prostate cancer in several large epidemiological studies, but not in all. The possible influences of dairy hormone in breast cancer are likewise unclear and in need of further definition.
The next few years will be fascinating for those of us interested in hormones and "the blight of youth." One wonders what the impact will be upon our patients, our practices, and the industries that make milk, hormones, and acne products. Time alone will tell.

F. William Danby: "Acne and milk, the diet myth, and beyond", J AM ACAD DERMATOL FEBRUARY 2005

While it seems very much up for debate to either substantiate whether indeed industrialised milk production schemes result in increased hormone presence in milk sold, whether there is a difference between production methods and 'ingredients' in milk sold, whether this is then true for all dairy products.

Case in point: water soluble pharmacologically active compounds will be greatly reduced in butter and ghee, molecules found in whey greatly reduced in most cheeses, and anything greatly processed is another game entirely. If yeasts, worms, insects bacteria ferment the milk-product, how much of the hormones is reduced by those organisms? –– or amplified?

Milk as is not the main product consumed by most people and all dairy products are clearly not the same. Kefir is different from cheese, fresh or aged, with bacteria or fungi, from whey, from butter, from ghee, from protein-isolate and so on. Given the different profiles for all those products they either have to have something in common across the board or they have to be analysed separately.

It is of course quite interesting to look for evidence that shows how much different modern milk and milk products are compared to just a few decades ago. Be it in nutritional or now even pharmacological profiles.

But to start a comparison with dairy, hypothesising about hormones, then linking that all up to skin disorders seems very premature and theoretical. At least if there are not clear epidemiological indicators of indeed a possible link.

Which suspects would there be to observe in the proposed link between acne and skin?

Only the most prominent are:

Prolactin, Somatostatin, Gonadotropin-releasing hormone, Luteinizing hormone, Thyroid-stimulating hormone, Thyreotropin-releasing hormone, Epidermal growth factor, Insulin-like growth factor 1, Insulin-like growth factor 2, Insulin, Vitamin D, Transferrin, Lactoferrin, Prostaglandins

Now which of these are contained in fresh milk under which circumstances and therefore concentrations in the first place? How much of this is linked to milking pregnant cows?

Acne and milk
Milk and other dairy products contain more than 60 molecules including prolactin, somatostatin, gonadotropin-releasing hormone, luteinizing hormone, thyroid-stimulating and thyreotropin-releasing hormones, insulin, epidermal growth factor, nerve growth factor, IGF-1 and 2, transforming growth factors, vitamin D, transferrin, lactoferrin and prostaglandins (Koldovsky, 1995). This makes it difficult to distinguish which of these factors could have an acneigenic effect, especially when this fact is combined with the broad range of dairy products (Table 25.2, Figure 25.4).
The most important factor of the ones mentioned above is the insulin-like growth factor. The IGFs are proteins with high sequence similarity to insulin. IGFs are part of a complex system that cells use to communicate with their physiologic environment. Cow milk contains IGF-1 and -2, even after pasteurization and homogenization, and bovine and human IGF-1 share exactly the same amino acid sequence (Melnik and Schmitz, 2009). High milk consumption increases IGF-1 levels 10%-20% in adults and 20%-30% in children (Hoppe et al., 2004 a, b) and milk and dairy products raise IGF-1 levels more than dietary proteins such as meat (Hoppe et al., 2005).
Milk also contains carbohydrates, including lactose, and therefore its consumption produces a glycemic response and an insulinemic response. The insulinemic response to ingested milk is actually three to six times what would be predicted from the carbohydrate load in the milk serving (Ostman et al., 2001). This happens for skimmed and full-fat milk, but not for cheese (Holt et al., 1997; Hoyt et al., 2005). The reasons are not yet understood, but they may relate to the insulinotropic effects of some of the other multiple hormones that are present in milk (Koldovsky, 1995). A glass of milk added to a low glycemic index meal can boost the insulin response up to 300% of the level produced by a high glycemic index meal and cow milk-formula does this even better than human breast milk (Liljeberg and Bjorck, 2001; Lucas et al., 1980). Different studies suggest that insulin rises in response to the whey component (20% of milk protein), whereas casein is responsible for the IGF-1 increase (Hoppe et al., 2006). Because whey and casein are both involved in stimulating androgen production, there is little point in further differentiating them in dietary restriction, since both should be avoided.

If the result of the above is indeed true: "whey and casein should both be avoided" then this is still incomplete as to whether it is for example whey-protein itself (essentialist reading) or what's commonly in there (varying by methods of production) as well and surely not encompassing 'all dairy', as butter for example is largely free of both.

Then it remains a stretch to conclude that "stimulating androgen production" is just "all bad/causes acne" on the one side and on the other side there are other types of causes that are "stimulating androgen production": hyperinsulinemia for example, which can also activate or upregulate IGF receptors.

It is simply too simplistic to reduce the focus to just one or a few pathways and "reason the rest" from there.

But take note that this is not the sole point of that article. The very next item was about 'glycemic index'. To give more context:

Key facts

  • Androgen excess, peroxisome proliferator-activated receptors and inflammation are the main pathogenetic mechanisms of acne.
  • Nutrition seems to play an important role in skin biology and pathology, affecting the onset and clinical manifestation of several dermatologic disorders, including acne.
  • The typical Western diet consists of numerous dairy sources and foods with high glycemic indices.
  • A study performed by Adebamowo et al. (2005) demonstrated the association between dairy products and acne.
  • A study provided by Smith et al. (2007) showed the link between high glycemic load intake of carbohydrates and acne.
  • High glycemic carbohydrates and milk appear to raise serum insulin levels, free IGF-1 and insulin resistance, thus contributing to the pathogenesis of acne.
  • IGF-1 seems to be the most important acneigenic factor contained in diet.
  • At the genomic level, the effects of insulin and IGF-1 are mediated by the nuclear concentration of the transcription factor FoxO1.
  • At the promoter level, SREBP-1c expression is suppressed by nuclear FoxO1, which is an important co-repressor of the retinoid X receptor and liver X receptor.
  • Dermatologists should be able to include dietary restriction in acne therapy management.

Summary points

  • Skin reflects individual age, health and beauty.
  • Nutritional customs affect several skin diseases including psoriasis, atopic dermatitis and acne.
  • Epidemiological studies with milk and dairy products support the association of milk consumption with acne onset and clinical course.
  • High glycemic load diets are also considered to be involved in acne pathogenesis because of the consequent hyperglycemia and hyperinsulinemia.
  • Dermatologists should include restrictive dietary management in acne therapy in their daily clinical practice.

A.I. Liakou, C.I. Liakou and C.C. Zouboulis: "Acne and nutrition", Victor R. Preedy (Ed): "Handbook of diet, nutrition and the skin", Wageningen Academic Publishers, Wageningen, 2012.

Note especially that 'dairy' is not unique in containing these molecules, concentrationand consumption patterns have to be observed as well. Dosis facit venenum. But even if the same molecules are measured, the effect may not be same after all, as the milk vs meat example aboive illustrates. And how much of those are even present in milk 'now' compared to 'earlier times' is partly dependent on the alleged production methods of "pregnant cows". How much has that changed? We can hardly know.

One of the more prominent papers investigating a possible link comes sponsored from a food-giant:

Bodo C. Melnik: "Evidence for Acne-Promoting Effects of Milk and Other Insulinotropic Dairy Products", Clemens RA, Hernell O, Michaelsen KF (eds): Milk and Milk Products in Human Nutrition. Nestlé Nutr Inst Workshop Ser Pediatr Program, vol 67, pp 131–145, Nestec Ltd., Vevey/S. Karger AG, Basel, © 2011.

And that is quite a problem. The dairy side sponsoring research to show how "good it is for you", and from animal-rights over vegan to frankenfood-companies financing the other side of ideology. All sides looking for evidence that they were right, from the start. This is more like gnosis that science and it is extremely difficult to weed out all the chaff thrown in to the pool of knowledge.

A meta-analysis can help inform the debate about the epidemiological evidence on dairy intake and development of acne. A systematic literature search of PubMed from inception to 11 December 2017 was performed to estimate the association of dairy intake and acne in children, adolescents, and young adults in observational studies. We estimated the pooled random effects odds ratio (OR) (95% CI), heterogeneity (I2-statistics, Q-statistics), and publication bias. We included 14 studies (n = 78,529; 23,046 acne-cases/55,483 controls) aged 7–30 years. ORs for acne were 1.25 (95% CI: 1.15–1.36; p = 6.13 × 10−8) for any dairy, 1.22 (1.08–1.38; p = 1.62 × 10−3) for full-fat dairy, 1.28 (1.13–1.44; p = 8.23 × 10−5) for any milk, 1.22 (1.06–1.41; p = 6.66 × 10−3) for whole milk, 1.32 (1.16–1.52; p = 4.33 × 10−5) for low-fat/skim milk, 1.22 (1.00–1.50; p = 5.21 × 10−2) for cheese, and 1.36 (1.05–1.77; p = 2.21 × 10−2) for yogurt compared to no intake. ORs per frequency of any milk intake were 1.24 (0.95–1.62) by 2–6 glasses per week, 1.41 (1.05–1.90) by 1 glass per day, and 1.43 (1.09–1.88) by ≥2 glasses per day compared to intake less than weekly. Adjusted results were attenuated and compared unadjusted. There was publication bias (p = 4.71 × 10−3), and heterogeneity in the meta-analyses were explained by dairy and study characteristics. In conclusion, any dairy, such as milk, yogurt, and cheese, was associated with an increased OR for acne in individuals aged 7–30 years.

However, results should be interpreted with caution due to heterogeneity and bias across studies.

Christian R. Juhl et al: "Dairy Intake and Acne Vulgaris: A Systematic Review and Meta-Analysis of 78,529 Children, Adolescents, and Young Adults", Nutrients 2018, 10(8), 1049, DOI

So it remains currently at this:

Dairy and Acne

There's no definite link between dairy and acne, but there are theories about it.

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