Questions tagged [dermatology]
Use this tag for questions about skin, nails or hair. This includes questions about normal structure or function as well as diseases or pathology.
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How can I methodically determine the cause of dog paw swelling? [migrated]
I have a 8 year old Shih Tzu that over a few months has developed swelling in the paws that her vet cannot figure out the cause of. I would like to be able to try something myself to determine the ...
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How do particular skin layers show (de)hydration characteristics?
On the subject of health tracking and biosensors, in particular optical sensors such as blood pressure, optical sensor and blood oxygen level. Would an optical sensor theoretically be able to ...
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How do doctors learn to spot cancer in moles?
It is very clear to me that doctors do not use the ABCDE rule to check a mole for skin cancer, as I probably have 30-40 moles that clearly violate one or more of these rules, yet the doctor always ...
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How does immunity against HPV work?
Premises:
The HPV vaccine(s) protect against infection with several HPV strains (the number depending on the exact vaccine), but don't cure existing infections.
HPV is not a blood-borne disease, i.e. ...
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Does skin picking cause skin cancer?
I was a skin picker (Dermatillomaniac) since several years ago. Of course I pick only the skin of my hand thumbs. I wish to quit it and I wish to know about two things here:
Does chronic skin picking ...
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How do dermatologists make a differential Diagnosis between Psoriasis, Parapsoriasis and Skin Lymphoma in an otherwise healthy person?
It seems to me, from the following Google Images search, that the dermatological symptoms for Psoriasis, Parapsoriasis and Skin Lymphoma are quite similar, excluding a certain type of Psoriasis named ...
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Pathologies that can lead to bleeding and cracked skin
What skin condition or pathology might be depicted in the current image?
Suggestions would be helpful as they would allow more closer follow-up investigation at a local dermatologist.
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What exactly causes dry skin to itch?
I know that dry skin can itch (since I'm almost sure I have it), but why? I don't really know anything about dermatology (or medicine generally) so the best hypothesis I can come up with is that ...
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What is the weakest steroid in systemic usage?
I understand that there are several steroids given as a systemic treatment in various doses and at various day times (morning or evening) adjusted by patient situation(1).
For example:
Prednisone
...
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What does current research show regarding the use of sunscreen in deeper skin tones?
I've struggled to find anything at all in the literature that specifically investigates the use of sunscreen as a preventative measure against sun damage in people with deeper skin tones.
Furthermore, ...
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Can fasting-induced autophagy impact vitiligo progression?
I recently came across a study titled "A Protective Role for Autophagy in Vitiligo" published in 2012, which is quite intriguing (source). However, the level of detail and technicality of ...
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Is the HSP70i protein involved in the cellular damage caused by most autoimmune disorders?
Inducible heat shock protein 70 (HSP70i) has gained attention for its potential role in treating vitiligo, an autoimmune skin disease. HSP70i mediates the depigmentation process caused by rogue T-...
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Is there a correlation between a vegan diet low in Vitamin B12 and the occurrence or severity of vitiligo?
Studies have shown a significant reduction of Vitamin B12 levels in individuals with vitiligo. This meta-analysis provides an overview: https://pubmed.ncbi.nlm.nih.gov/30165163/
Results: Twenty-two ...
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What are the exact effects of turmeric (curcumin) topical cream on skin in general, and specifically in regards to vitiligo?
A study from 2022 as published in this article titled "Therapeutic effects of turmeric topical cream in vitiligo: A randomized, double-blind, placebo-controlled pilot study" (source) states:
...
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How would (topical versus oral) copper (Cu) and zinc (Zn) affect the chronic auto-immune skin condition Vitiligo?
A Chinese study from 2014 with the title "Decreased copper and zinc in sera of Chinese vitiligo patients: a meta-analysis" (source) states:
Abnormalities of copper (Cu) and zinc (Zn) are ...
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What effects could oral supplementation of the co-enzyme Q10 have on chronic auto-immune skin condition Vitiligo?
I've found two interesting studies regarding the co-enzyme Q10 in relation to the chronic autoimmune disorder Vitiligo.
From the publication "Q10-triggered facial vitiligo" (source):
...
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Does any mechanism of action exist that would allow topical application of jojoba oil to down-regulate sebum production?
This study found that adapalene (brand name Differin) suppresses "TG and PLIN1 production in differentiated hamster sebocytes" leading to the stated goal of "an inhibitory action for ...
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Patches of Partial Albinism
In this site: https://www.myvitiligoteam.com/resources/albinism-vs-vitiligo-whats-the-difference, at the header "Partial Albinism vs. Vitiligo" it says that Partial Albinism(which I think is ...
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A vitamin supplement can be both water and fat soluble? [closed]
How can these nutritional facts included supplement can be defined? Water-soluble or fat-soluble?
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Why do herpes virus infections (apart from chicken pox) resolve without dermatological sequelae?
OK, first, needed research and a bunch of other articles.
I've seen hundreds of cases of recurrent HV infections (labialis, zoster, etc.) uncomplicated by secondary infection, some of which looked ...
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How do clinicians prevent haloperidol-induced seborrheic dermatitis?
I understand that seborrheic dermatitis is a possible side effect of haloperidol, an old, widely used, typical anti psychotic drug.
Assuming that this reported side effect is real and not a mistake,
...
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Where, in the human skin, would lidocaine cream stop but lidocaine injections won't?
In some medical procedures lidocaine is injected and in some others it is topically administered as a cream.
Histologically speaking, where, in the human skin, would lidocaine cream stop but lidocaine ...
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What's optimal from a cosmesis standpoint between applying a single or a double freeze-thaw cycle to treat a thick seborrhoeic keratosis?
I'm reading contradictory statements.
{2} states:
Two freeze/thaw cycles (with a shorter freeze time) are more effective for thicker lesions such as seborrhoeic keratosis and warts.
However, {3} ...
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What's the success rate of Imiquimod Cream 5% recommended for the treatment of facial superficial basal cell carcinoma beyond 5 years post-treatment?
I have read several studies on the success rate of Imiquimod Cream 5% for the treatment of facial superficial basal cell carcinoma, however none of them looked at beyond 5 years post-treatment. E.g. {...
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What is the difference in cosmesis of the treatment of a seborrheic keratosis between cryotherapy and electrodesiccation?
There exist different treatments to remove a seborrheic keratosis (SK), such as cryotherapy and electrodesiccation {1}. I wonder what the difference in cosmesis of the treatment of a seborrheic ...
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Does combining silicone gel therapy and pressure therapy help scar reduction (vs. using just one of these therapies)?
The 2015 review {1} mentions different therapies for scar reduction, including:
Treatment
Description
Advantages
Disadvantages
Pressure therapy
Application of elastic bandages or pressure garments ...
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Does ingesting itraconazole pills increase the likelihood of success for a topical cream (Imiquimod/5-Fluorouracil) to treat BCC?
The 2014 phase II trial {1} indicates that oral itraconazole is beneficial for the treatment of basal cell carcinoma (BCC). Imiquimod 5% cream and topical 5-Fluorouracil (5-FU) have also been used to ...
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Why are some areas of the face more likely to have basal cell carcinoma (BCC) recurrences than others?
BCC = basal cell carcinoma.
I read on {4}:
Certain clinical and pathological features of BCC are associated with an elevated risk for recurrence after treatment. Recurrent BCC may reappear months to ...
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How accurate is reflectance confocal microscopy (RCM) to predict whether a basal cell carcinoma (BCC) is infiltrative or superficial?
Reflectance confocal microscopy (RCM) is a noninvasive imaging technique that has been used to diagnose basal cell carcinoma (BCC). How accurate is RCM to predict whether a BCC is infiltrative or ...
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Is it true that freckles have zero potential for malignant transformation?
This New York City dermatologist called Dr. Bobby Buca on this web page says:
"Freckles and moles have two things in common: there is a genetic tendency to get them, and both are darker than the ...
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Probability to develop a new type of melanoma
I saw that there are different types of melanoma: some are more aggressive and others are less dangerous. From what I understood searching on web, the causes of melanoma are not clear but there are ...
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Is there a method to distinguish nail from skin, for example examination under a microscope?
Is it possible to distinguish parts of toenail from skin, for example under a microscope?
Say I had a hypothesis that some toenail material had wound its way down the toe and spread out under the sole ...
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What percentage of facial basal cell carcinomas (BCC) are superficial or infiltrative?
I read here (mirror):
Superficial basal cell carcinoma: Approximately 10-15% of all BCCs are of this type. This is the most common pattern seen in BCCs of the shoulder.
The solid (nodular) type ...
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Why do shave biopsies and punch biopsies used to diagnose suspected facial basal cell carcinomas measure a few mm instead of being below 1mm?
Given a neoplasm of uncertain behavior of skin on a patient's face that is suspected to be a basal cell carcinoma (BCC), the typical first step is to perform a shave biopsy to determine the type of ...
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Why isn't imiquimod cream used prior to performing a biopsy used for suspected facial basal cell carcinomas?
Given a neoplasm of uncertain behavior of skin on a patient's face that is suspected to be a basal cell carcinoma (BCC), the typical first step is to perform a shave biopsy to determine the type of ...
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Does any drug/cream help prevent DNA damage post UV exposure?
I read on https://medicine.yale.edu/news-article/sun-damage-occurs-even-after-sunset/:
When UV light hits the skin , it causes a type of DNA damage known as a cyclobutanepyrimidinedimer (CPD) , in ...
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To what extent do UV-A, UV-B and UV-C exposure account for visible signs of aging in the skin? I'm looking for a breakdown between UV-A, UV-B and UV-C
Several studies indicate that UV exposure account for between 80% to 90% of visible signs of aging in the skin.
E.g., from {1}:
UV exposure may account for up to 80% of visible signs of aging in the ...
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Is there any known correlation between stomach worms and fungal skin infections?
Is there any literature which points to correlation between worm infestation of the intestines and fungal infection of the skin?
The possible mechanism being the stomach worms disrupting natural ...
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For how long does the application of topical retinoids increase photosensitivity?
I read on https://www.medscape.com/viewarticle/726464_6:
Owing to potential photosensitivity, topical retinoids are best applied at night and patients should not expose themselves to excessive UV ...
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Can foods one is not allergic to exacarbate atopic dermatitis?
Several physicians (incl. two profesors in allergology, regarded among highest authorities in allergology in my country) told me and insisted that people with atopic dermatitis must avoid certain ...
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How to treat blisters on burnt skin after initial period?
In google, there are plenty of articles about what to do (i.e. First Aid) when you get skin-burn (doing this or that...etc..). However, I was unable to find any solid article that refer to treating of ...
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Does alternating silicone sheets with silicone gel yield a better scar reduction than using silicone sheets or silicone gel alone?
ScarAway's packaging mentions (ScarAway is one of the main brands for silicone gels and silicone sheets in the United States):
For best results: Use as part of a complete scar treatment regimen, ...
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What is the difference in cosmesis of the treatment of a seborrheic keratosis between cryotherapy and curettage?
There exist different treatments to remove a seborrheic keratosis, such as cryotherapy and curettage+electrodesiccation {2,3}. I wonder what the difference in cosmesis of the treatment of a seborrheic ...
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Why may a small basal cell carcinoma (BCC) treated with radiation be much more aggressive than it appears on the surface?
I read on https://www.skincancer.org/blog/ask-the-expert-why-am-i-having-surgery-to-remove-a-small-basal-cell-carcinoma/ (mirror):
In addition, a small BCC in an area previously treated with ...
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Do 50% of individuals with a history of BCC will develop another one within 5 years of diagnosis regardless of the age of the individual?
https://skinio.com/education/basal-cell-carcinoma/ (mirror) says:
Patients diagnosed with BCC should be examined by their dermatologist at least twice a year. Remember, 50% of individuals with a ...
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How accurate is dermoscopy to predict if a skin lesion is a basal cell carcinoma (BCC), and if it is, whether it is superficial or aggressive form? [closed]
https://dermnetnz.org/cme/dermoscopy-course/dermoscopy-of-basal-cell-carcinoma/ mentions that one can use dermoscopy to diagnose basal cell carcinoma (BCC) and their subtype (nodular, superficial, etc....
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Why isn't Imiquimod Cream 5% recommended for the treatment of superficial basal cell carcinoma located on the face?
I read on Approval Package for Imiquimod Cream, 5% on February 25, 2010 (mirror):
Reference Drug (NDA number): Aldara® (imiquimod) 5% Cream (NDA 20-723), Graceway
Pharmaceuticals. Date of approval: 2/...
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How effective is topical fluorouracil to treat facial superficial basal cell carcinoma (BCC) after Imiquimod 5% cream failed to treat it?
Both Imiquimod 5% cream and topical 5-Fluorouracil (5-FU) have been used to treat basal cell carcinoma (BCC) with a fair amount of success (~60 to 90% success rate at 5-year follow-up) {1}.
Imiquimod ...
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Which criteria are used to choose whether to perform a shave biopsy or a punch biopsy to diagnose suspected facial basal cell carcinomas?
Given a neoplasm of uncertain behavior of skin on a patient's face that is suspected to be a basal cell carcinoma (BCC), the typical first step is to perform a shave biopsy to determine the type of ...
- 10.3k
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0
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Should Imiquimod 5% cream be applied 1 cm beyond the target tumor when treating a facial basal cell carcinoma, and if so, why?
I read on https://www.accessdata.fda.gov/drugsatfda_docs/label/2004/20723s016lbl.pdf (mirror):
364 patients with primary superficial basal cell carcinoma (sBCC) were treated with Aldara Cream or ...
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