D.Tan
  • Member for 3 years, 10 months
  • Last seen more than a month ago
  • New York, NY, USA
Does COVID-19 cause myocardial infarctions?
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5 votes

Cardiovascular disease is known to worsen during infections such as influenza through two proposed mechanisms: cytokines from the resulting inflammation cause weaken atherosclerotic plaques and cause ...

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Why does metastatic bone cancer present as back pain that is "worse at night"?
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3 votes

Not sure why I didn't think of this earlier, but back pain that is worse at night due to metastatic cancer to the spine is caused by tumor compressing spinal cord when lying on your back. Anything ...

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Why is prothrombin time used to monitor warfarin and not aPTT?
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3 votes

According to UpToDate: At levels of therapeutic anticoagulation, VKAs (vitamin K antagonists) typically cause only mild prolongation (or do not prolong) the activated partial thromboplastin time (...

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Is breathing into a paper bag an effective treatment for panic attacks?
2 votes

Breathing into a paper bag to control hyperventilation might improve hypocarbia, but should NOT be done because of the risks of hypoxia and death. This case report shows that breathing into a paper ...

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How does hyperventilation cause paresthesia and tetany?
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2 votes

The two proposed mechanisms for paresthesia/tetany secondary to hyperventilation are cerebral vasoconstriction and electrolyte imbalance. Cerebral vasoconstriction: Cerebral blood flow decreases in a ...

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How come Anti-D administered to Rh-negative mothers doesn't cause sensitization to the Rh antigen
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2 votes

According to this 2006 review article: In summary, the evidence indicates that prevention of RhD immunization by prophylactic anti‐D might occur both by rapid macrophage‐mediated clearance of anti‐...

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Why is prothrombin time not used to monitor the effects of heparin?
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2 votes

Most PT assays contain polybrene, which neutralizes heparin. According to "Coagulation assays and anticoagulant monitoring": Polybrene is a positively charged material that will neutralize UFH, and ...

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Is there a direct correlation between high testosterone level and weak immune system?
2 votes

According to this 2016 Nature Review article (which cites the article from your link): Androgens have been show to reduce immune response in a variety of studies. For example: In vivo exposure to ...

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Why bother prescribing oral antibiotics for acne, when C. acnes can't all be killed and will regrow?
2 votes

Oral antibiotics (traditionally tetracyclines) have been found effective for treating acne for many years. Two major mechanisms inlcude: inhibiting the growth of C. acnes anti-inflammatory effect (...

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What is the rationale behind using Il-6 inhibitors to treat COVID-19 patients?
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2 votes

Hemophagocytic lymphohistiocytosis (HLH) syndrome is a life-threatening condition commonly triggered by viral illness. It is caused by over-activated macrophages and low NK cell/cytotoxic T-cell ...

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Nutritional sodium deficiency -- documented cases?
1 votes

Tea and Toast syndrome is a well-known cause of hyponatremia due to a diet with restricted salt/protein intake but abundant fluids ("tea and toast"), usually occurring among elderly who are ...

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Obstructive sleep apnea (OSA) - what level of respiratory dysregulation is involved and are respiratory stimulants relevant?
1 votes

Although not a "respiratory stimulant" in the sense of stimulating muscles of respiratory, hypoglossal nerve stimulation devices, such as INSPIRE, can stimulate your tongue to move forward ...

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Why does Delayed Post-hypoxic Leukoencephalopathy (DPHL) have a biphasic clinical course?
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1 votes

The brain is made up of oxygen-demanding gray matter and myelin-covered white matter. Hypoxic events initially damage the gray matter, but myelin is spared. However, new myelin secretion requires ATP-...

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How does refeeding syndrome cause pitting edema?
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1 votes

During refeeding syndrome (RFS), intake of carbohydrates causes a massive surge in insulin levels, leading to electrolyte abnormalities. Increased insulin also caused sodium and water retention ...

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What is the clinical difference between cold sores (HSV-1) and herpetiform canker sores?
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1 votes

Based on the history, oral herpes would present with a history of oral-to-oral contact or oral-to-genital contact with someone with an active herpes infection. Canker sores generally have idiopathic ...

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Is there research on the relative effectiveness of different social distancing measures?
1 votes

3Blue1Brown made a great video (Simulating an Epidemic) showcasing the effects of tweaking various parameters on outbreaks using simulations. Background: His simulation is based on the SIR model, ...

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What is the mechanism of action of tamoxifen and other SERMs on Gynecomastia?
1 votes

According to this review article: Estradiol and, to lesser degree, other estrogens, increase proliferation of breast epithelium and stroma and, consequently, increase the chances of mutation in ...

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What is mesenchymal tissue?
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1 votes

During a process called gastrulation, an embryo forms 3 basic tissue layers: ectoderm, mesoderm, and endoderm. In general terms, the ectoderm forms the skin and nervous system, the mesoderm forms the ...

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What causes the long tiredness caused by the infectious mononucleosis disease (by the Epstein-Barr virus)?
0 votes

According to Emedicine medscape: Appreciate that EBV may trigger chronic fatigue, but it does not cause chronic fatigue. In their page on Chronic Fatigue Syndrome: CFS is a biological illness, ...

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Why does congenital duodenal obstruction cause a "double bubble" sign to appear on imaging?
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-1 votes

Duodenal obstruction is classified as either stenosis (narrowing of duodenum) or atresia (complete occlusion of duodenum). In both cases, a "double bubble" sign appears because of gas trapped in the ...

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