Yes, it is possible for topical Tacrolimus to cause systemic toxicity, in certain situations.
Evidence from a case series
This paper is a case report of two patients who were prescribed topical Tacrolimus (and other therapy) for post-transplant cutaneous graft versus host disease (GVHD).
Their Tacrolimus trough levels (a way of measuring the blood level ...
There is no cure for vitiligo, but there are treatments that may reduce the discoloring in your skin and possibly even restore skin color. The main treatments used by doctors are either restoring the skin to normal color, or bleaching the skin, so that all of the skin is an even color. They do these things in a number of ways, including topical treatments ...
There are several components to this question:
Is hydrogen peroxide (as used in dental hygiene procedures) absorbed into the body in significant quantities?
Could absorbed hydrogen peroxide have systemic effects?
To what extent is oxidative stress a factor in the pathogenesis of vitiligo?
Can absorbed hydrogen peroxide contribute to the pathogenesis of ...