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46 votes
Accepted

Are Covid-19 vaccines much more deadly than people (and scientists) think?

https://vaers.hhs.gov/data/dataguide.html provides a useful guide for interpreting these data. VAERS deaths are not causal reports, they're just a report where someone (doctor, family member) decided ...
Bryan Krause's user avatar
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17 votes

Why is post exposure vaccines given for some diseases & why does it work?

A vaccine essentially simulates an infection so that our body produces antibodies against it & thus helps when we actually get infected in the future. Sometimes and sometimes not. That's a good ...
anongoodnurse's user avatar
8 votes

Are Covid-19 vaccines much more deadly than people (and scientists) think?

VAERS has a useful purpose, but in high profile situations such as this the data is often more reflective of data collection issues rather than actual effects of vaccination. In addition to the ...
user3067860's user avatar
8 votes
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Did 79% of pregnancies in an early COVID-19 vaccine study result in loss?

No, please refer to the rest of the sentence: Among 3958 participants enrolled in the v-safe pregnancy registry, 827 had a completed pregnancy, of which 115 (13.9%) were pregnancy losses and 712 (86....
Ian Campbell's user avatar
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6 votes
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Does a shorter COVID-19 vaccination interval increase efficacy of booster vaccines?

Seeing, as from comments you are interested in any time difference, this is a fairly simple question of vaccine prime and boost strategies. After an immunization or infection, the adaptive immune ...
bob1's user avatar
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5 votes
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Why are mRNA vaccines not yet available against other diseases?

A few-year-old review that might be useful is: Pardi, N., Hogan, M., Porter, F. et al. mRNA vaccines — a new era in vaccinology. Nat Rev Drug Discov 17, 261–279 (2018). https://doi.org/10.1038/nrd....
Armand's user avatar
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5 votes
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How does Pfizer vaccine affect covid test?

This question is clearly answered by the CDC's "Myths and Facts about COVID-19 Vaccines" Will getting a COVID-19 vaccine cause me to test positive for COVID-19 on a viral test? No. None of ...
Ian Campbell's user avatar
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5 votes
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What does negative vaccine efficacy mean in the attached article?

Vaccine efficacy refers to some relationship between a vaccinated and unvaccinated group; there are multiple ways to measure this, see for example this Q&A on Biology: https://biology....
Bryan Krause's user avatar
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4 votes

Are vaccines much more deadly than people (and scientists) think?

we will never know that the vaccine have a probability to kill of ~0.1% Very unlikely given that randomized trials with thousands of participants have been conducted; one meta-analysis pooled 41,141 ...
got trolled too much this week's user avatar
4 votes

Why is aspiration not commonly used for IM vaccine administration in the U.S.?

The CDC gives this as the reason why not: Aspiration before injection of vaccines or toxoids (i.e., pulling back on the syringe plunger after needle insertion but before injection) is not necessary ...
got trolled too much this week's user avatar
4 votes
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Is there any general consensus in the research on what the maximum duration is that the mRNA vaccine spike remains in the body?

There is a bit of information around, and like @BryanKrause said, half-lives are a more useful measure of the life-time of the system rather than complete clearance, which can't be measured easily for ...
bob1's user avatar
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3 votes
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Can you get shingles if you never have had chickenpox but got the chickenpox vaccine?

The CDC and the FDA are authoritative sources. As always you can check the package insert for your particular vaccine formulation. In this case you need the Description section on page 8 of the ...
bob1's user avatar
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3 votes
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is Typhim Vi a live vaccine?

At the not so subtle hinting of Carey Gregory... There are a couple of methods of determining the specifics of vaccines. The authoritative method is to use the package insert. This tells you all about ...
bob1's user avatar
  • 3,501
3 votes
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Can patients receive SHINGRIX together with TWINRIX or AREXVY?

The US Centers for Disease Control has a page which discusses simultaneous administration of SHINGRIX with other vaccines: CDC general recommendations advise that recombinant and adjuvanted vaccines, ...
Ian Campbell's user avatar
  • 3,254
3 votes

How would you properly interpret this graph?

On the Y-axis, you can see this is labeled as a cumulative incidence; cumulative means you're adding up over time. So, all the curves have to go up as you go to the right, because over time you ...
Bryan Krause's user avatar
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3 votes
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Why do some vaccines have only a short protection span?

The most obvious reason why a vaccine may have limited use is mutation. Flu vaccinations are only useful for a season since the dominance of the many Influenza serotypes changes pretty quickly over ...
bloomtom's user avatar
3 votes

What is the authoritative US document that delineates concrete standards for vaccine approval?

There is no "authoritative document" like you ask for. The FDA doesn't set concrete standards for efficacy and safety; rather, they review applications for vaccines and other drugs on a case-...
Bryan Krause's user avatar
  • 14.2k
2 votes

Are viral loads in vaccinated people only infectious with the delta variant? If so, why not with previous COVID-19 variants?

The White House reports (1) that several studies show that those with breakthrough infections of Delta had viral loads that were similar to people who were infected and unvaccinated, and that in this ...
user1521620's user avatar
2 votes

Are viral loads in vaccinated people only infectious with the delta variant? If so, why not with previous COVID-19 variants?

We have no real scientific data released yet, but here are some things to think about. Being infected, feeling sick and being contagious are three different things. Certainly, many fewer of the ...
Armand's user avatar
  • 992
2 votes

Why are mRNA vaccines not yet available against other diseases?

From the links you've supplied, none of these other vaccines have gotten further than phase 2 trials yet. Most seem to only have phase 1 trials started or merely planned so far. These vaccines are not ...
Bryan Krause's user avatar
  • 14.2k
2 votes

Did the NIH study find Moderna - Moderna gave more antibodies than Moderna-Pfizer?

TLDR: in the actual paper/preprint, neither for the raw antibody values nor for the ratio relative to day 1 is there a statistically significant difference between Moderna-after-Moderna and Pfzier-...
got trolled too much this week's user avatar
1 vote
Accepted

What is the recommended interval for HPV vaccines such as Gardasil 9 for women and men up to age 45?

The Center's for Disease Control and Prevention provides recommendations for all vaccines appropriate for adults. For HPV: Age 15 years or older at initial vaccination: 3-dose series at 0, 1–2 months,...
Ian Campbell's user avatar
  • 3,254
1 vote

Are viral loads in vaccinated people only infectious with the delta variant? If so, why not with previous COVID-19 variants?

Note that I am no virologist but am explaining to the best of my knowledge and for practical use from a variety of reports and my own understanding from my background in Nursing and Health Informatics....
Meia's user avatar
  • 19
1 vote
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A recent Israeli study found the Pfizer COVID-19 vaccine to have only 64% efficacy against the Delta strain - is that with full vaccination?

The New York Times (https://www.nytimes.com/live/2021/07/06/world/covid-19-vaccine-coronavirus-updates) presents several studies indicating good 2-dose protection against symptomatic infection: ...
user1258361's user avatar

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