9 votes
Accepted

Should chronic low cortisol be treated if the patient has no symptoms?

The disease associated with low cortisol is known as adrenal insufficiency (so-called because the adrenal glands are responsible for cortisol production). Morning cortisol is not a definitive test for ...
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  • 4,355
8 votes
Accepted

How do topical steroid withdrawal relate to adrenal insufficiency?

Good question! The missing bit of information here is that topical steroids are usually not absorbed systemically at high enough levels to cause adrenal suppression. However, they sometimes are. I ...
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  • 4,355
5 votes
Accepted

Can tacrolimus creme cause tacrolimus toxicity?

Yes, it is possible for topical Tacrolimus to cause systemic toxicity, in certain situations. Evidence from a case series This paper is a case report of two patients who were prescribed topical ...
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  • 2,331
3 votes

Aloe Vera and Diabetes

This study did a thorough literature search of all existing Aloe Vera research and found, at best, weak conclusions: The current evidence suggests some potential benefit of Aloe vera in improving ...
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3 votes

What causes acne, and how do I get rid of it?

According studies, it's an interaction between genetics and environment. If you parents had acne, you might have. But, overall, diet and stress are big factors for acne : your genetic makes you more ...
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  • 151
3 votes

Where, in the human skin, would lidocaine cream stop but lidocaine injections won't?

The depth of topical lidocaine penetration is time-dependent (for the amount of time it is on the skin). In one study they found that with topical lidocaine placed on the skin for 90 minutes, the mean ...
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  • 79
3 votes
Accepted

Even topical tetracycline causes teeth discoloration?

Unlikely. Tetracycline topical is generally well tolerated. Side effects reported with systemic administered tetracycline such as gastrointestinal complaints, vaginitis, hematologic ...
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  • 2,952
3 votes
Accepted

Does aloe vera fade acne scars?

Yes. It is used as a gel. WebMd.com Aloe seems to be able to speed wound healing by improving blood circulation through the area and preventing cell death around a wound. It also appears ...
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  • 2,952
3 votes
Accepted

Acne underneath skin

Currently, the only real way to "get rid of acne once and for all" is through the use of the prescription medication isotretinoin. It works to reduce sebum production and thusly decreases the ...
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2 votes
Accepted

Contradictory advice from doctor and packaging

This is something you should contact your doctor about as soon as you can; it would also be wise to talk to the pharmacy where you had the prescription filled. In this case, I would tend to trust the ...
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  • 864
2 votes

Not in the face? Why is this warning on my lotion?

Interesting question. I remember my professor of pharmaceutical technology and pharmaceutics addressing this when we discussed the significance of dosage form design. The skin on one’s face is far ...
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2 votes

How can 5% and 10% concentrations of benzoyl peroxide, be less effective than the 2.5%?

You are reading the outcome incorrectly, the 5% and 10% formulations are not less effective, they are equally effective. The specific text is The 2.5% benzoyl peroxide formulation was more effective ...
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2 votes
Accepted

How does chlorhexidine cause discolouration in teeth?

There are several possible mechanisms, probably all acting together. The brownish deposits on teeth and tongue are mostly caused by the fact that bacterial proteins are denatured when the bacterial ...
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  • 6,757
1 vote
Accepted

How deep into the skin do topical acne medications penetrate?

Cystic acne are often called "severe acne." Treatment of cystic acne usually involves prescribed drugs, so it's a doctor (a dermatologist) who prescribes them. These drugs can have serious side ...
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  • 15.6k
1 vote

If apply regular warm compress unto my scalp, will it mimic the use of topical vasodilators?

According to the french equivalent of the FDA, the ANSM, in a minoxidil presentation Resume des Caracteristiques Produit : Le mécanisme précis d'action n'est pas connu. Translation : The ...
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1 vote

Procoagulant salve/cream/gel?

Depending on your definition of "wound" you could consider a styptic pencil. It's generally used for nicks and small cuts, such as you get while shaving. Most drugstores sell them or you can order ...
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  • 3,744
1 vote

Not in the face? Why is this warning on my lotion?

In my experience, such warnings are typically present if ingredients in the lotion would irritate the eyes or mouth—problems that can't happen if you avoid applying it to the face. My reasoning goes ...
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  • 589
1 vote

Even topical tetracycline causes teeth discoloration?

When taken orally tetracycline can cause discolouration in developing teeth and should be avoided - when possible - in young children. Systemic tetracycline will have no effects on the colour of fully ...
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1 vote

Why are retinoids applied only after washing the face?

Both retinoids and benzoyl peroxide must be absorbed by the skin to do their work. If you have make-up on or oily skin etc. this can be a barrier to absorption so must be cleaned off. The cleaner your ...
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