29 votes
Accepted

Why do doctors prescribe steroid tablets even though they know the side effects?

I think a missing bit of information that might help you get a better sense of this practice is: steroids are miracle drugs. OK, that was in jest - no miracles here. Truth be told, though, if there ...
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  • 4,355
20 votes
Accepted

Why do corticosteroids harm COVID-19 patients?

One of the primary purposes of corticosteroids is to suppress immune activity and inflammation: that's exactly why they are used in asthma. Of course the immune system has an actual job besides ...
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  • 11.7k
8 votes
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How do topical steroid withdrawal relate to adrenal insufficiency?

Good question! The missing bit of information here is that topical steroids are usually not absorbed systemically at high enough levels to cause adrenal suppression. However, they sometimes are. I ...
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  • 4,355
6 votes

Why do doctors prescribe steroid tablets even though they know the side effects?

This is a very good question. Simply put: among doctors we call them wonder drugs or life saving drugs. In a number of emergencies, such as severe drug reactions, life-threatening asthma or allergies,...
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6 votes
Accepted

What is the time frame of developing adrenal suppression when taking oral corticosteroids?

This question arises from your (correct) understanding that administration of exogenous (i.e. not produced by the body) glucocorticoids (GCs) can suppress the body’s ability to produce its own GCs in ...
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  • 4,355
5 votes

Why are cortisone injections deleterious for tendons?

One study published in 1996 in the Clinical Journal of Sport Medicince said that there are insufficient published data to determine the comparative risks and benefits of corticosteroid injections. ...
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  • 4,697
5 votes
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How do steroids work in treating a multiple sclerosis relapse?

Steroids are used as treatment for acute attacks/flares in many diseases because they reduce inflammation. In multiple sclerosis, they are given to reduce inflammation of the nerves that occurs when ...
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  • 6,998
4 votes
Accepted

Is there reasonable cause to suspect that taking creatine increases risk of testicular cancer causatively?

Issues with the 2015 study Demographics First of all, any conclusions in the paper about the connection between creatine use and TGCC apply almost entirely to Caucasian males, not all males, as you ...
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4 votes
Accepted

Is calling dexamethasone a "psychoactive steroid medication" correct use of the term psychoactive? Because it has reported psychological side effects?

Dexamethasone and other steroids have well-documented psychological effects. There are so many citations available that it's not necessary to pick one in particular. The definition of "...
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  • 9,314
4 votes
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Low dose and high dose dexamethason supression test

In a dexamethasone supression test, it is measured whether given the patient dexamethasone leads to lowered cortisol levels. Lowered cortisol levels are the normal response to dexamethasone; if the ...
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  • 6,998
3 votes

Psychosis while using prednisone: how long will it last?

I'm sorry to hear about your recent psychosis. The mood/psychological effects of glucocorticosteroids are well documented. http://www.ncbi.nlm.nih.gov/pubmed?term=22764363 http://www.ncbi.nlm.nih....
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  • 209
3 votes
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Severe asthma and autoimmune skin reactions with no relief

There are numerous causes and sources of irritation for Asthma exacerbations. Your objective is finding out whether it's irritants (smoke, chemicals, lint, etc) or allergies (pollen, pet dander) that ...
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  • 209
3 votes

Why are cortisone injections deleterious for tendons?

Effects of cortisone ie. glucocorticoids (GCs) are very variable. One effect of GC is the inhibition of collagen formation. Collagen is the main ingredient of tendons. Collagen units form the ...
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  • 2,322
3 votes

What are the long term health risks from repeated cortisone injections?

I'll start off by highlighting a couple of more general studies: Cole & Schumacher (2005): A general study of corticosteroids, this found that some corticosteroids may be free of side effects (...
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  • 1,838
2 votes

Why do corticosteroids harm COVID-19 patients?

The Lancet article you referenced in your question answered the questions you asked. In the trials of high dose corticosteroids used to treat SARS patients Corticosteroids use was: not associated ...
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  • 13.2k
2 votes

Are steroids effective for treatment of ACEI-induced angioedema?

Unfortunately the answer to your question is we simply do not know. There have been no trials of antihistamines or corticosteroids for ACEI associated angioedema and these treatments are of ...
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  • 1,680
2 votes
Accepted

How do corticosteroids cause high blood pressure?

I've found a supporting source for the fluid retention claim, in an excerpt from Holland-Frei Cancer Medicine, 6th edition (from 2003). This separates the effects on the kidney into two categories, ...
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  • 1,838
1 vote
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Why do corticosteroids have few kidney-related side effects?

Corticosteroids block the enzyme Phospholipase A2 (PLA2) which catalyses the first step in arachidonic acid synthesis pathway. But, NSAIDs blocks activity of cyclooxygenases (COX 1 and COX 2). So, ...
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