I am not sure if I understood your question correctly and also this is not my main field of knowledge, even though let me try to make my contribution with this (not final) answer.
Stem cells can be categorized into several groups depending on their ability to differentiate:
Totipotent: can differentiate into all cell types;
Pluripotent: can differentiate ...
The question of the efficacy of stem cell treatments is a topic of great current (October 2020) interest with randomized clinical trials on-going or planned for a variety of conditions.
This 2020 publication is a systematic review of studies of mesenchymal stromal cell-based therapies for the treatment of osteoarthritis.
Maleitzke T, Elazaly H, Festbaum C, ...
Whilst the Science Museum of London points out that we seem to be close to developing complete human organs, there appears to be a few more years before we are able to grow the first complete usable organ.
For example, Lytal (2018) points out that so far, scientists haven’t been able to create complete adult human kidneys because they’re too complex, but ...
Different cell lines exist for different reasons, depending on the cell type and their properties they are useful for different experiments.
HEK-293 - Embryonic Stem Cells - Female
WI-38 - Fibroblasts derived from lung tissue - 3 month old female
MRC-5 - Fibroblasts derived from lung tissue - 14 week old male
Embryonic stem cells are totipotent, meaning ...
I'll admit, this is far from being clear and I don't have enough points to make this as comment yet but let me try to give you a help with this pseudo-answer.
After birth, hematopoiesis is mainly limited to the red bone marrow, with some lymphatic tissues assisting in the production of lymphocytes.
All blood cell elements are derived from a single population ...
Is your question focused on the clinical trial on the spine, rather than arthritis in general? If so, the following articles will be helpful.
As for the PRPs, how about this review?
They conclude that;
Clinical studies for evaluating the effects of the injection of PRP into degenerated IVDs for patients with discogenic LBP have been reviewed. Although there ...
In addition to @Andrew's answer about technical limitations, consider that searching for "HEK-293" for example on Google Scholar returns over 120,000 results.
The thousands and thousands of studies using these cell lines provides an extensive institutional body of knowledge. There are many foundational studies done to understand these cell lines ...
■What is the ATMPs
I didn't clearly read from the EMA's description of the ATMP, whether the ATMP is as being a "sales approval" or a "preferential treatment that lowers the bar to obtain approval".
Perhaps the noun "ATMP" has three different meanings; I was confused because of the mix of these in the EMA's site.
Box1. Three ...
I'd like to preface with a brief summary of both techniques:
Bone marrow donation - The stem cells are removed from a large bone of the donor, typically the pelvis, through a large needle that reaches the center of the bone.
Peripheral blood stem cell transplantation - The stem cells may come from the blood of the patient or a donor. A peripheral blood stem ...