5
votes
Accepted
Migraines and tryptophan
Sumatriptan activates vascular 5-HT1 receptors. This results in vasoconstriction, which is what is thought to help the migraines. This is the same idea for giving caffeine, which is also a ...
2
votes
What is the relationship between cortisol and depression?
TL;DR
There isn't really a scientific consensus. There appears to be a connection between cortisol and depression, but cortisol anomalies appear neither necessary nor sufficient for depression
The ...
- 6,594
2
votes
How does vortioxetine cause nausea when it inhibits 5HT3-receptors?
Its primary action is as NaSSA (a noradrenergic and specific serotonergic antidepressant), not as 5-HT3 inhibitor. If you have a look at e. g. the Wikipedia page (https://en.wikipedia.org/wiki/...
- 1,157
1
vote
How does vortioxetine cause nausea when it inhibits 5HT3-receptors?
I was mistaken, the 5HT3 inhibitor of Vortioxetine is not responsible for the nausea, see here
Its additional antagonism of 5-HT3 receptors may partly counteract gastrointestinal adverse effects but ...
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