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Sumatriptan activates vascular 5-HT1 receptors. This results in vasoconstriction, which is what is thought to help the migraines. This is the same idea for giving caffeine, which is also a vasoconstrictor. Taking tryptophan would likely be ineffective for a variety of reasons in terminating a migraine. First, it would have to be ingested and absorbed, ...


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TL;DR There isn't really a scientific consensus. There appears to be a connection between cortisol and depression, but cortisol anomalies appear neither necessary nor sufficient for depression The scientific community believed that there is a strong connection between the "happiness hormone" serotonin (5-HT or 5-hydroxytryptamine). This so-called ...


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Its primary action is as NaSSA (a noradrenergic and specific serotonergic antidepressant), not as 5-HT3 inhibitor. If you have a look at e. g. the Wikipedia page (https://en.wikipedia.org/wiki/Mirtazapine#Pharmacodynamics), you will see that nausea is listed as side effect under "discontinuation syndrome", i. e. sudden withdrawal from continuous 5-...


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I was mistaken, the 5HT3 inhibitor of Vortioxetine is not responsible for the nausea, see here Its additional antagonism of 5-HT3 receptors may partly counteract gastrointestinal adverse effects but nausea has an important role on drug discontinuation. Its additional antagonism of 5-HT3 receptors may partly counteract gastrointestinal adverse effects but ...


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