5 votes
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Migraines and tryptophan

Sumatriptan activates vascular 5-HT1 receptors. This results in vasoconstriction, which is what is thought to help the migraines. This is the same idea for giving caffeine, which is also a ...
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2 votes

What is the relationship between cortisol and depression?

TL;DR There isn't really a scientific consensus. There appears to be a connection between cortisol and depression, but cortisol anomalies appear neither necessary nor sufficient for depression The ...
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  • 6,594
2 votes

How does vortioxetine cause nausea when it inhibits 5HT3-receptors?

Its primary action is as NaSSA (a noradrenergic and specific serotonergic antidepressant), not as 5-HT3 inhibitor. If you have a look at e. g. the Wikipedia page (https://en.wikipedia.org/wiki/...
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  • 1,157
1 vote

How does vortioxetine cause nausea when it inhibits 5HT3-receptors?

I was mistaken, the 5HT3 inhibitor of Vortioxetine is not responsible for the nausea, see here Its additional antagonism of 5-HT3 receptors may partly counteract gastrointestinal adverse effects but ...
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  • 151

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