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First of all, if you found papers that suggest certain unexplored side effects, it means the research is underway and it can very well be that in the next years we get new information about how drugs work. Now to the actual question. From the pharmacokinetic point of view, PPIs only affect proton pumps of the stomach. The solution behind this is very simple: ...


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"Proton pump" is a broad category of proteins rather than a specific pump. The drugs called "proton pump inhibitors (PPIs)" to reduce stomach acid target a specific proton pump, the hydrogen/potassium ATPase. Of course, it is possible for drugs to have off-target effects at other proteins, especially similar ones. It is also possible for ...


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Only your healthcare provider can help diagnose and treat YOUR situation, so keep working with them on this. But what I can do is help reflect your own statements back to you. Regarding the recommendations that your doctor gave you: (1) You say you're not responding to weight loss - but that you are still 40 lbs overweight. You have reduced your ...


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I would first and foremost attempt to lose weight; nevertheless, Endoscopy is not really the the optimal test to diagnose hiatal hernia. You should do a double-contrast Esophagus-Stomach-Duodenal X-Ray. As for what Gene said re: PPIs, it makes no sense. Their mechanism of action is to inhibit the chemical mechanism that allows the gastric parietal cells to ...


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