5

Yes, it is possible for topical Tacrolimus to cause systemic toxicity, in certain situations. Evidence from a case series This paper is a case report of two patients who were prescribed topical Tacrolimus (and other therapy) for post-transplant cutaneous graft versus host disease (GVHD). Their Tacrolimus trough levels (a way of measuring the blood level ...


4

What do you think the immune systems of the recipient animals are doing to the human donor tissue/organ? And if you immunosuppress those recipient animals, then you need to consider the effects of those drugs on the donor tissue/organ too. In short, putting an organ into the animal (and the animal using the organ, as with the kidneys in the paper you cited) ...


3

Whilst the Science Museum of London points out that we seem to be close to developing complete human organs, there appears to be a few more years before we are able to grow the first complete usable organ. For example, Lytal (2018) points out that so far, scientists haven’t been able to create complete adult human kidneys because they’re too complex, but ...


2

Liver donation - an act of great honor - should only be done once. Liver regeneration occurs via compensatory hyperplasia. Regeneration of the liver can be more correctly defined as compensatory hyperplasia where in the remaining liver tissue expands to meet the metabolic needs of the organism. Unlike anatomic true regeneration, the expanding liver does not ...


1

According to the standard blood compatibility chart: (image from Owlcation: The Basics of Blood and Blood Typing - Wikipedia file) AB blood types can only donate to other AB blood types, but AB blood types can receive from other blood types, so what is the point of being an AB donor. Well, the chart says that they are the only blood type that can do a ...


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