7 votes

Baby aspirin interaction with other NSAIDs

Is it right and safe to prescribe this combination (NSAID like diclofenac + baby Aspirin) specially with the knowledge that this combination gonna be used for a long time? While NSAID are ...
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  • 905
7 votes
Accepted

Why isn't Tylenol safe?

The main risk of Tylenol (aka acetaminophen/paracetamol) is liver damage, as this article from the FDA advises: This drug is generally considered safe when used according to the directions on its ...
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  • 1,390
5 votes
Accepted

Do NSAIDs "Relieve Pain" or is it a Byproduct?

Injury or infection triggers the release of prostaglandins, which can cause pain, fever and inflammation (all of which are direct effects of prostaglandins). Painkillers and Prostaglandins (Nature): ...
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  • 15.6k
4 votes

At what daily dose does daily aspirin use become dangerous for a long-term user?

Aspirin, just like all NDSAIDs, affects enzymes associated with pain transmission; they are COX-1 and COX-2 (cyclooxygenase-1 and 2). COX-1 helps protect the stomach and intestinal lining from the ...
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  • 1,390
3 votes
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Preventing NSAID-associated GI bleeding

There is convincing evidence that measures, like crushing the tablets before use, taking them with food or water, lower doses and temporary discontinuation of use, are associated with the lower risk ...
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  • 15.6k
3 votes

At what daily dose does daily aspirin use become dangerous for a long-term user?

Aspirin is a platelet inhibitor. As such it has a number of bleeding risks - including GI bleeding as described above. Risks also include increased bleeding risk from injury including cuts, bruising, ...
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  • 5,694
2 votes

Is it safer to take Naproxen once a day or twice a day?

Naproxen has a half-life of between twelve and seventeen hours.1 Constant steady-state serum levels of Naproxen are produced after four to five days..1 It stands to reason that the lower the dose the ...
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  • 1,390
2 votes
Accepted

Can ibuprofen and paracetamol be taken together?

Yes, it is safe. The mechanism that ibuprofen and paracetamol use are different and don't interact negatively. In fact, the two drugs (medicines) can be used in conjunction for a synergistic effect so ...
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2 votes

At what daily dose does daily aspirin use become dangerous for a long-term user?

Commonly prescribed dose of aspirin for certain types of arthritis can be as high as 4 g/day (Drugs.com). For angina pectoris and heart attack prevention, even low doses (75-325 mg/day) can result in ...
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  • 15.6k
2 votes

Do painkillers cure headaches or just stop us from feeling it?

How do painkillers work? When part of your body is injured, special nerve endings send pain messages back to your brain. Painkilling drugs interfere with these messages, either at the site of the ...
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2 votes

Do NSAIDs (specifically Naproxen) help facilitate the passage of kidney stones?

Non-steroidal anti-inflammatory drugs and the kidneys You’re right that non-steroidal anti-inflammatory drugs (NSAIDs) have an effect on the glomerular arterioles by inhibiting prostaglandin ...
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  • 2,331
2 votes

Do NSAIDs "Relieve Pain" or is it a Byproduct?

The way in that this question is framed looks like a false dichotomy. The very first sentence of a recent book starts with: NSAIDs are one of the most widely prescribed drugs around the world to ...
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  • 6,747
1 vote
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Why do corticosteroids have few kidney-related side effects?

Corticosteroids block the enzyme Phospholipase A2 (PLA2) which catalyses the first step in arachidonic acid synthesis pathway. But, NSAIDs blocks activity of cyclooxygenases (COX 1 and COX 2). So, ...
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1 vote

Preventing NSAID-associated GI bleeding

Speaking from my humble experience, when prescribing NSAIDs (especially long-term, e.g. Aspirin as thrombosis prophylaxis) it is standard to combine those with PPIs (Proton Pump Inhibitors) as ...
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  • 709
1 vote

Do NSAIDs "Relieve Pain" or is it a Byproduct?

Simply, Nonsteroidal anti-inflammatory drugs (NSAIDs) produce their therapeutic activities (Pain and Inflammation relief) through inhibition of cyclooxygenase (COX), the enzyme that makes ...
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1 vote

How to decide which painkiller to take?

1. NSAIDs can increase the chance of heart attack or stroke. This risk may be greater if you have heart disease or risk factors (for example, smoking, high blood pressure, high cholesterol, diabetes) ...
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  • 1,848
1 vote

Safe alternatives to painkillers/nsaid?

I am really happy that I found Krill oil. It's an omega 3,6,9 oil made from krill. (a sea creature similar to shrimp but much smaller). It makes this choice the strongest choice in benefits of any ...
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