4

Short answer Excessive Acetylcholine (Ach) release seems to be related Calcitonin Gene-Related Peptide (CGRP) inducing Ach leakage. CGRP is part of a general inflammatory response, in turn part of the pain response associated with trigger points. Background Physiologically spoken, acetylcholine (Ach) is released in the neuromuscular junction by the ...


2

Increased vascular permeability means fluid leaks more readily from blood vessels. That leakage builds up in the surrounding tissue, which causes edema. The edema squeezes veins, thereby compressing them, which means they can't do their job of draining the tissue efficiently, and that can lead to the vicious circle he mentions. Vasodilation means the ...


1

A chain of events that leads to release of sensitizing substances, according to Dry needling — peripheral and central considerations (PubMed Central, 2011): ...muscle pain would cause spasm of the same muscle, and in turn would cause more pain leading to more spasms. Sustained contractures of taut bands cause local ischemia and hypoxia in the core ...


Only top voted, non community-wiki answers of a minimum length are eligible