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14 votes
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Can mRNAs modify our DNA (publication misunderstanding)?

The short answer is maybe, but rarely, and the whole Covid virus has never been seen to integrate into the cell's DNA intact. Any integration requires "helper" molecules not found in the ...
Armand's user avatar
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9 votes
Accepted

Do mRNA Vaccines tend to work only for a short period of time?

Short answer - no, the mRNA vaccines specifically don't only work for a short period of time. Natural infection and all vaccines of different types against SARS-CoV-2 all produce similar durations of ...
bob1's user avatar
  • 3,486
6 votes

Moderna vs Pfizer COVID-19 vaccine mechanisms

They both encode the full spike. The two mRNA front-runners share many commonalities. Both take advantage of modified RNA chemistry to encode the SARS-CoV-2 spike protein with stabilizing mutations ...
the gods from engineering's user avatar
5 votes
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Why are mRNA vaccines not yet available against other diseases?

A few-year-old review that might be useful is: Pardi, N., Hogan, M., Porter, F. et al. mRNA vaccines — a new era in vaccinology. Nat Rev Drug Discov 17, 261–279 (2018). https://doi.org/10.1038/nrd....
Armand's user avatar
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4 votes
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Is there any general consensus in the research on what the maximum duration is that the mRNA vaccine spike remains in the body?

There is a bit of information around, and like @BryanKrause said, half-lives are a more useful measure of the life-time of the system rather than complete clearance, which can't be measured easily for ...
bob1's user avatar
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3 votes

Does this Covid-19 vaccine study suggests a 1 to 718 rate of adverse effects?

I am neither a medical professional nor a statistician, so caveat emptor and all that Short answer is no. This is because, in the article the authors state: A total of 1,736,832 persons were eligible ...
bob1's user avatar
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2 votes

Why are mRNA vaccines not yet available against other diseases?

From the links you've supplied, none of these other vaccines have gotten further than phase 2 trials yet. Most seem to only have phase 1 trials started or merely planned so far. These vaccines are not ...
Bryan Krause's user avatar
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2 votes

Does this Covid-19 vaccine study suggests a 1 to 718 rate of adverse effects?

I think there's some missing the forest for the trees here, in the sense that adverse events (aka adverse effects) generally do not have a strict definition beyond something like: untoward medical ...
the gods from engineering's user avatar
1 vote

Why is booster shot needed when mRNA vaccines can induce memory cells?

Re: If so, then there is no need to have a third booster shot. Why do you think this? Consider chicken pox/shingles. Clearly, infection with chicken pox once leads to immunity lasting for many many ...
Armand's user avatar
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1 vote

Does antigen expression from an mRNA vaccine damage the host cell?

I'm not a biologist, and it's difficult to find a straightforward explanation, but it sounds like the cells present the spike protein on their surface, and are then recognized as infected and killed ...
endolith's user avatar
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