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PCOS can make your body resistant to insulin. When your body's cells become too resistant to insulin, that's called type 2 diabetes. Metformin makes your body more sensitive to insulin, so it can help prevent type 2 diabetes in PCOS patients who do not yet have it. Metformin doesn't treat PCOS itself, and it's not approved by the FDA to treat PCOS. Its use ...


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Metformin has effects on many body systems and its many effects are not completely understood, as explained in this 2019 review article discussing use of metformin to treat Type II diabetes mellitus. Foretz, M., Guigas, B. & Viollet, B. Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus. Nat Rev Endocrinol 15, 569–589 (...


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The following information obtained by searching PUBMED is NOT a systematic review. The search yields interesting information in support of the speculation by the previous answer (and by Crouse) that an effect of metformin in reducing the risk of mortality in patients with COVID-19 might be explained by an anti-thrombotic effect of metformin. One of the ...


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The latter paper (Crouse, et al.) discusses this: Interestingly, metformin has previously been shown to also have anti-inflammatory (16, 17) and anti-thrombotic effects (18, 19) and excessive inflammatory responses, e.g., cytokine storm as well as disseminated thromboembolic events have been recognized as deadly complications of COVID-19 infection (20–22). ...


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Metformin, a dimethylbiguanide, is a widely used oral antihyperglycaemic drug for the long term treatment of type 2 diabetes mellitus. It lowers blood glucose in multiple ways, including suppression of hepatic gluconeogenesis, increased peripheral insulin-mediated glucose uptake, decreased fatty acid oxidation, and increased intestinal glucose consumption. ...


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This study was examining the effects of metformin on hormone levels responding to hypoglycemia. It found that metformin did not significantly alter the body's hormonal response to hypoglycemia in their study population. Study It looks like according to the study that recurring hypoglycemia can cause a lowering of cortisol: Antecedent hypoglycemia ...


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