7 votes
Accepted

Where does Ibuprofen inhibit COX-1, and what is its MoA?

I'm not clear why you're asking this as this information is readily available unless I missed something in your question. As for anticoagulant activity, my recollection is that if anything Ibuprofen ...
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6 votes
Accepted

How is Lopinavir + Ritonavir expected to stop COVID-19?

The NEJM editorial that accompanied that issue says: One antiviral-drug candidate is a combination of the HIV protease inhibitors lopinavir and ritonavir. Lopinavir, which acts against the viral 3CL ...
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  • 5,773
6 votes
Accepted

"Mechanism of Action" (MOA) of medical drugs

Mechanism of Action (MOA) refers to the effects of a drug on a molecular level (receptors, chemical reactions) and Mode of Action (MoA) to the effects on a functional or tissue level, which are more ...
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5 votes

Demodex control with antibiotics: why and how?

The Demodex mite is part of normal skin flora but is often implicated in conditions like rosacea, folliculitis and blepharitis (inflammation of the eyelids). Erythromycin is an effective treatment. ...
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  • 2,331
3 votes
Accepted

How does the "leucovorin rescue" work exactly? Why doesn't it make cancerous tumours grow?

I will interpret your question in the more generalised form of "why doesn't folic / folinic acid supplementation reduce the efficacy of methotrexate treatment?" The question may be better in this more ...
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  • 250
2 votes
Accepted

How does amiloride increase calcium reabsorption in the kidneys?

Regarding calcium transport in the kidney: In contrast with the proximal tubule and the thick ascending limb of the loop of Henle, the distal tubule reabsorbs calcium exclusively via the ...
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  • 1,157
1 vote

What is the mechanism by which paracetamol improves sleep?

It is rather suggestive of a nocebo effect since there is no mechanism to explain a connection between sleepiness/weakness and paracetamol use. According to eHealthMe, out of the 1,171 people who ...
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  • 1,848

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