7

I'm not clear why you're asking this as this information is readily available unless I missed something in your question. As for anticoagulant activity, my recollection is that if anything Ibuprofen is one of the worse NSAIDs in terms of cardiovascular side effects being prothrombotic, though not as bad as Diclofenac. The main mechanism of action of ...


6

The NEJM editorial that accompanied that issue says: One antiviral-drug candidate is a combination of the HIV protease inhibitors lopinavir and ritonavir. Lopinavir, which acts against the viral 3CL protease, has modest antiviral activity against SARS-CoV-2. A quick search shows that SARS-CoV 3CL protease was the topic of some more in-depth investigations, ...


6

Mechanism of Action (MOA) refers to the effects of a drug on a molecular level (receptors, chemical reactions) and Mode of Action (MoA) to the effects on a functional or tissue level, which are more observable. So, actually, in most cases, we know how a drug works, because we can see its effects, but we may not know "how exactly" it works. Wikipedia has ...


5

The Demodex mite is part of normal skin flora but is often implicated in conditions like rosacea, folliculitis and blepharitis (inflammation of the eyelids). Erythromycin is an effective treatment. Its mechanism of action is to bind to the 50s subunit of the ribosome (involved in manufacturing proteins in cells) and so inhibits the synthesis of proteins. ...


3

I will interpret your question in the more generalised form of "why doesn't folic / folinic acid supplementation reduce the efficacy of methotrexate treatment?" The question may be better in this more generalised form so a moderator may want to edit it more towards that. The review in [1] strongly suggests that folic acid supplementation does not reduce the ...


2

Regarding calcium transport in the kidney: In contrast with the proximal tubule and the thick ascending limb of the loop of Henle, the distal tubule reabsorbs calcium exclusively via the transcellular route. See also: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491294/ Also, calcium availability in blood (and hence for filtration in the kidney) is ...


1

It is rather suggestive of a nocebo effect since there is no mechanism to explain a connection between sleepiness/weakness and paracetamol use. According to eHealthMe, out of the 1,171 people who reported side effects on paracetamol 64 reported weakness as a side effect, 33 sleepiness as a side effect


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