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Metformin has effects on many body systems and its many effects are not completely understood, as explained in this 2019 review article discussing use of metformin to treat Type II diabetes mellitus. Foretz, M., Guigas, B. & Viollet, B. Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus. Nat Rev Endocrinol 15, 569–589 (...


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Insulin resistance refers to decreased ability of insulin receptors in the cell membranes to respond to insulin. Insulin resistance (Wikipedia): Insulin resistance implies that the body's cells (primarily muscle) lose sensitivity to insulin, a hormone secreted by the pancreas to promote glucose utilization. At the molecular level, a cell senses ...


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Actually, ketoacidosis could occur also in Type 2 Diabetes. It's not common, but it's a possibility and should not be not omitted. In Type 2 Diabetes the insulin secretion is available but insufficient to meet the glucose needs. However, generally, can prevent sustained hyperglycemic states that could lead to ketoacidosis. When DKA occurs in patients ...


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In summary, there is a strong evidence to say that the risk factors for cardiovascular disease (CVD) include: High LDL-cholesterol Insulin resistance High saturated/unsaturated fat intake ratio and high trans fat intake High intake of refined carbohydrates High LDL-cholesterol and CVD The Role of Lipids and Lipoproteins in Atherosclerosis (Comprehensive ...


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This study did a thorough literature search of all existing Aloe Vera research and found, at best, weak conclusions: The current evidence suggests some potential benefit of Aloe vera in improving glycaemic control in prediabetes and type 2 diabetes. However, given the limitations of the available evidence and the high heterogeneity in study results, high-...


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I think you're confused by what is meant as a genetic disease. A disease like Huntingdon's Chorea is a genetic disease because we know the genetics, and we know that it occurs due to mutation in an autosomal dominant gene so the chance of inheritance is 50% with almost 100% penetrance. Diseases like T2DM have a genetic basis so that we know some groups are ...


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After massive searching I found a suitable fact sheet. Its primary focus is diabetes but it includes the basic information I need to get across about insulin resistance. https://www.cdc.gov/diabetes/pubs/statsreport14/national-diabetes-report-web.pdf Insulin resistance is explained succinctly, and well, on p. 9. Also, the difference between the terms "...


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