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The primary endpoint is the thing you design your study around. You choose a sample size based on a statistical power analysis, making sure you have enough participants that you will be able to detect a statistically significant effect if there is a large enough actual effect. Your p-value for your primary end point should be a good p-value if you've pre-...


3

Your understanding about the mechanism by which the K+ ions leak out of the cardiac cell during ischaemia is correct. But, regarding the latter part, lets discuss what is the situation of K+ ions in a normal cardiac cell. In a normal cardiac cell, the concentration of K+ ions is more inside compared to the outside of the cell (150mM inside as compared to 4mM ...


1

It is a known fact that STDs are more easily transmitted by unprotected anal intercourse. As some STDs are known to (rarely) cause endocarditis, it seems plausible to me that unprotected anal intercourse increases the risk of an endocarditis. I could, however, find no statistical analysis on the relationship between (receptive) anal intercourses and ...


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