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Two key serum concentrations to know about in pharmacodynamics and pharmacokinetics are the Minimum Effective Concentration (MEC) and Toxicity Concentration (TC). Some medications have stronger effects the higher the concentration, and other medications have the same effects regardless of the concentration as long as it is above the MEC. Note that the ...


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It means that the receptors are blocked forever. A cell is a living thing, continuously producing new proteins (including receptors) and recycling old ones. So the cell is not defective forever, it will slowly phase out its blocked receptors and replace them with new ones. You can read the basics of the way receptors work in textbooks on cell signalling, ...


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The concentration of drugs declines based on a property of the specific drug called pharmacokinetics. Here's a broad-brush strokes overview (more info here): A drug with zero order kinetics declines linearly. This is often the case if a drug is metabolized by an organ such as the liver. Alcohol has 0-order kinetics. If your blood alcohol level is 0.8 at ...


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I’ve found a quotation that sheds some light on the topic: The rate of termination of the action of a reversible antagonist is largely dependent on the half-life of the drug as well as the rate at which it dissociates from its receptor: the shorter the half-life, the less time it takes until the effects of the drug are dissipated. However, the ...


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