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6 votes

Can Smith-Lemli-Opitz Syndrome be caused by medication?

The following is of course, in case the diagnosis is confirmed. SLO is an autosomal recessive pathology, which means both parents are carrier of one mutated allele of the DHCR7. They do not express ...
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6 votes

Can Smith-Lemli-Opitz Syndrome be caused by medication?

Smith-Lemli-Opitz syndrome is a genetic condition that only occurs if both parents are carriers of the mutation. For each chromosome that isn't a sex chromosome, we get one copy from each parent, so ...
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5 votes

Digestion and absorption of large scale protein structures

Do some proteins survive human digestion? Yes. Prions are misfolded proteins with abnormal tertiary or quaternary structures. That grants them resistance (to some extent, at least) to proteases (1). ...
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4 votes

How much hard liquor is safe for very small children?

As I argue in my answer to this question, there seems to be a threshold in terms of the amount of alcohol likely to cause hepatocellular necrosis based on the production of acetaldehyde. However, ...
2 votes

Why is trypsin inhibitor present if trypsin is already secreted in form of trypsinogen?

This excellent description of the pathophysiology of digestion answers your question by explaining in more detail how trypsinogen gets from the pancreas to the intestinal lumen. "Several ...
2 votes

How relevant is TMPRSS2 for the entry of common-cold coronaviruses?

The answer seems somewhat complex for 229E. It seemingly evolved in us for better utilization of TMPRSS2, as Shirato et al. (2016) report: Human coronavirus 229E (HCoV-229E), a causative agent of the ...
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2 votes

Are there drugs that help to digest wheat?

In short: There are digestive enzymes available as supplements (amylase, cellulase, alpha-glycosidase) that can help digest starch and certain types of fiber in wheat. There is no convincing evidence ...
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