11 votes
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Does Benadryl (=diphenhydramine) lead to tolerance? Can I use it to help with sleep?

First generation H1-antihistamines (such as diphenhydramine = Benadryl) are well known for their sedative effects explaining their limited use in patients with allergic rhinitis. Several ...
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3 votes
Accepted

Can early exposure to stimulates, like ritalin, result in higher tolerance to them?

Yes, unfortunately, Ritalin produces a tolerance in individuals who take it. In the conclusion of this double blind trial, the author notes, Acute tolerance to methylphenidate appears to exist. ...
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  • 4,896
3 votes

Is Moderated Caffeine Good? (if so how much and how often)

If you take coffee daily, you no longer get a boost from it after about a week, but rather, you're just staving off the harsh withdrawal symptoms, not to mention over time it will physically change ...
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  • 151
2 votes

How serious is the antibiotic resistance problem?

Pneumococcal pneumonia was the most prevalent form of bacterial pneumonia in the community at over 70% of cases but that number has drastically fallen presumably due to the use of pneumococcal ...
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  • 13.2k
2 votes

How much caffeine intake a day is still safe for health?

I have found an article published in November 2017 that states: "Evidence supported consumption of ≤400 mg/day in adults is not associated with overt, adverse effects." Link to the article: https://...
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  • 151
1 vote
Accepted

Higher doses of a drug being less effective?

Drugs may have different actions at different concentrations. So, for instance: Buprenorphine is 25 to 100 times more potent than morphine.18 Buprenorphine exhibits partial agonist behavior at the ...
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  • 13.2k

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