11
votes
Accepted
Does Benadryl (=diphenhydramine) lead to tolerance? Can I use it to help with sleep?
First generation H1-antihistamines (such as diphenhydramine = Benadryl) are well known for their sedative effects explaining their limited use in patients with allergic rhinitis. Several ...
- 3,193
3
votes
Accepted
Can early exposure to stimulates, like ritalin, result in higher tolerance to them?
Yes, unfortunately, Ritalin produces a tolerance in individuals who take it.
In the conclusion of this double blind trial, the author notes,
Acute tolerance to methylphenidate appears to exist. ...
- 4,896
3
votes
Is Moderated Caffeine Good? (if so how much and how often)
If you take coffee daily, you no longer get a boost from it after about a week, but rather, you're just staving off the harsh withdrawal symptoms, not to mention over time it will physically change ...
- 151
2
votes
How serious is the antibiotic resistance problem?
Pneumococcal pneumonia was the most prevalent form of bacterial pneumonia in the community at over 70% of cases but that number has drastically fallen presumably due to the use of pneumococcal ...
- 13.2k
2
votes
How much caffeine intake a day is still safe for health?
I have found an article published in November 2017 that states:
"Evidence supported consumption of ≤400 mg/day in adults is not associated with overt, adverse effects."
Link to the article:
https://...
- 151
1
vote
Accepted
Higher doses of a drug being less effective?
Drugs may have different actions at different concentrations.
So, for instance:
Buprenorphine is 25 to 100 times more potent than morphine.18 Buprenorphine exhibits partial agonist behavior at the ...
- 13.2k
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