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5 votes
Accepted

What is the meaning of doubling of bioavailability?

1. Measure blood concentration over time through IV administration First you need to administer a drug in a manner that has 100% bioavailability, or completely enters the systemic circulation. This ...
faustus's user avatar
  • 785
4 votes

Activated charcoal administered rectally?

Yes, activated Charcoal (AC) can be given rectally. Although this is a veterinary journal, I doubt the principles are different and according to this article it's given in a liquid slurry, much like ...
Carey Gregory's user avatar
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3 votes

Would slight shifting of administration times of Paxlovid impact its efficacy?

This is a pharmacokinetic question, as it refers to the effect of changes in the prescribed dosage regimen on the amount of drug in the body, which is usually related to the magnitude of effect the ...
Don_S's user avatar
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2 votes
Accepted

The process of drug approval; The flow from R&D, planning a clinical trial to drug approval, or other additional process

I'm afraid it would be frowned you all if I answered it by myself and took my response as a solution, but... As I mentioned in the comments section above, I found a very summarized resource on the FDA'...
Blue Various's user avatar
1 vote
Accepted

Muscarinic receptors in bladder

According to this paper (full text freely available), "the somatic pudendal nerve stimulates striated muscle of the external urethral sphincter, mediated by ACh activating nicotinic (N) receptors&...
Don_S's user avatar
  • 1,618
1 vote

What is injected into the IV to wake a patient up from general anesthesia?

I do know that something can be injected into a patient's IV to wake them up immediately from general anaesthesia. That's not how it works. Many anaesthetics only work for minutes at best. A normal ...
Narusan's user avatar
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1 vote

How would oral medication be given to patient in ICU that can't swallow?

After some research I found this topic which answers part of my question. It does not answer the chemical effects of mixing drugs outside the human body. 1-Nasogastric medications. 2-drug-...
NoChance's user avatar
  • 111
1 vote

How would oral medication be given to patient in ICU that can't swallow?

Through a nasogastric tube. What you call "interaction" would be previously known by general and common knowledge of pharmacology. The doctor must know about those interactions, the nurse simply ...
whitebeltcoder's user avatar

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