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If it is planned this way, it can be seen to be combination therapy but generally it would be monotherapy throughout. Generally speaking, monotherapy is using one medication to treat a condition. If that medication is not as effective as required and an alternative was later prescribed it is still monotherapy. If more than one medication is prescribed in the ...


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Metformin has effects on many body systems and its many effects are not completely understood, as explained in this 2019 review article discussing use of metformin to treat Type II diabetes mellitus. Foretz, M., Guigas, B. & Viollet, B. Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus. Nat Rev Endocrinol 15, 569–589 (...


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