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Two things: Clinical trials are generally double-blinded, meaning that neither the subjects nor the researchers know what the subject is receiving, and Potential ethical issues are considered ahead of time by both the researchers as well as Human Subject Review Committees who have to approve the research protocol.


Two facts you need: first, clinical trials have very strict rules for who can be in them. Second, some trials are "drug A vs placebo" while others are "Drug A vs Drug B" or "Drug A vs Drugs A and B together" not to mention variations in dose etc. It's not all a matter of "we won't treat half the participants." I was in ...


Full Background The full-text of the study that Dr. Goldstein discusses is available online at: Chen MH, Tsai SJ, Su TP, Li CT, Lin WC, Chen TJ, Pan TL, Bai YM. Increased Risk of Stroke in Patients With Obsessive-Compulsive Disorder: A Nationwide Longitudinal Study. Stroke. 2021 May 27:...

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