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I think you're confused by what is meant as a genetic disease. A disease like Huntingdon's Chorea is a genetic disease because we know the genetics, and we know that it occurs due to mutation in an autosomal dominant gene so the chance of inheritance is 50% with almost 100% penetrance.
Diseases like T2DM have a genetic basis so that we know some groups are ...
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I think this question is too vague for a definite answer, but areas to consider would include:
confounding vs effect modifier: where do smoking and condition A lie in relation to the outcome of mortality?
matched pairs study: if it is ethical, you could get a simple random sample consisting of people with condition A that do not smoke and pair each ...
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