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Cardiovascular disease is known to worsen during infections such as influenza through two proposed mechanisms: cytokines from the resulting inflammation cause weaken atherosclerotic plaques and cause plaque rupture/thrombosis stress from illness can precipitate decompensated heart failure in predisposed patients Two studies from Wuhan have looked into this ...


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You can think of blood volume and blood vessels as a closed system for your nitrates example. Vasodilation does not change blood volume; it changes the volume the container (the blood vessels) can hold. The result is that with more "room" for the blood to occupy, your blood pressure falls. That's why hypertensive emergencies (e.g. hypertensive ...


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A case series in Seattle published in JAMA on March 17, 2020 describes a potential cardiomyopathy associated with coronavirus in critically-ill patients. Current thinking includes a potential direct cardiac effect of the COVID-19 viral infection, rather than atherosclerotic or ischemic disease per se. The authors noted: It is unclear whether the high ...


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I think this is probably due to selection bias, but I cannot find a source from someone in the field to reference. Instead, to support this conclusion, note that in the review you reference, the people with near-occlusions overall have fewer negative outcomes than those with lesser occlusions. People who are not already dead while having such a blockage ...


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The resistance is defined as pressure difference per flow (basically just an application of Ohm's law). With Hagen-Poiseulle: So if the alveoli diameter is reduced to half (resulting in a halved radius), as the resistance changes by the fourth, it is increased by factor 16 (24). Note: As the bronchioles terminales are connected parallel, they actually do ...


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