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The brain is made up of oxygen-demanding gray matter and myelin-covered white matter. Hypoxic events initially damage the gray matter, but myelin is spared. However, new myelin secretion requires ATP-dependent enzymes which is impaired by hypoxic event. Since myelin takes about ~20 days to cycle, this coincides with the biphasic presentation of DPHL. Another ...


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This all falls to a matter of degree - most importantly mechanism of injury. I'll explain the physics in allegorical terms first and then explain as it relates to medicine. The mechanism refers to the amount of force experienced in the injury process which allows us to predict injury patterns. For example: A motor vehicle collision at highway speed has a ...


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