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The NEJM editorial that accompanied that issue says: One antiviral-drug candidate is a combination of the HIV protease inhibitors lopinavir and ritonavir. Lopinavir, which acts against the viral 3CL protease, has modest antiviral activity against SARS-CoV-2. A quick search shows that SARS-CoV 3CL protease was the topic of some more in-depth investigations, ...


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As of August 24, 2020, the jury is out on your question--Can the replication and transmission of the SARS-CoV-2 (2019-nCoV) virus in humans be inhibited in a similar way by the use of oseltamivir? It could be answered definitively only in a randomized trial. The company that manufactures Tamiflu—the branded version of oseltamivir--seems not to consider ...


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This drug is not one of the candidates for the WHO mega study "Solidarity" nor do I see it in any other prospective trial. Without trial data your question can not be answered. WHO and partners are organizing a study to compare untested treatments throughout several countries. “This large, international study is designed to generate the robust data we ...


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No one knows. It’s possible, and there are clinical trial underway to determine any effect eg https://www.bbc.co.uk/news/health-52504409


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As soon as a virus is replicating effective antiviral drugs can hamper or even prevent its progression. This principle is used for Pre-exposure prophylaxis, and more like in this case in question in Post-exposure prophylaxis. With something like Oseltamivir it should work similarly. Clinical Question: How effective are oseltamivir and zanamivir at ...


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According to the World Health Organization Administering the vaccine up to 3-5 days after exposure has been shown to reduce the severity of the disease significantly, but studies vary greatly as to whether or not post-exposure vaccination can prevent the disease entirely. Post-exposure treatment with antiviral drugs is effective at reducing the severity of ...


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All interferons interfere with viral replication but until the Cubans show that their drug Interferon alpha 2B is any better than anything else, then there's nothing to recommend it over anything else used in the treatment of COVID-19. The list of drugs recommended by CPAM are: For direct antiviral treatment of SARS-CoV-2, CPAM recommends use of ...


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In, shingles, pain commonly persists after rash disappearance and usually disappears on its own. If the pain lasts for more than 30-90 days after rash disappearance, it is called postherpetic neuralgia (PHP). Antivirals, such as acyclovir, famciclovir and valcyclovir, do not help in postherpetic neuralgia. Postherpetic neuralgia, NEJM: Antiviral drugs ...


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