11 votes
Accepted

Why should males use contraception for longer after taking molnupiravir for COVID?

The mechanism of action of molnupiravir is "lethal mutagenesis" (see Malone and Campbell, 2021) - it interferes with the viral RNA polymerase by introducing copying errors severe enough that ...
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6 votes
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How is Lopinavir + Ritonavir expected to stop COVID-19?

The NEJM editorial that accompanied that issue says: One antiviral-drug candidate is a combination of the HIV protease inhibitors lopinavir and ritonavir. Lopinavir, which acts against the viral 3CL ...
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  • 5,773
3 votes

(Why) are there so few studies of ivermectin as an antiviral in animal models?

First, we should focus on "ivermectin plus covid19 or a virus that mimics covid19. For now, the FDA recognizes ivermectin as an antiviral drug. Therefore, the comparison should be "antiviral ...
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3 votes
Accepted

Was KP-1461 found to be not a good drug?

From Mullins, J. I., Heath, L., Hughes, J. P., Kicha, J., Styrchak, S., Wong, K. G., ... & Parkins, J. (2011). Mutation of HIV-1 genomes in a clinical population treated with the mutagenic ...
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2 votes
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Can oseltamivir shorten the duration of COVID-19 and inhibit replication and transmission of the SARS-CoV-2 (2019-nCoV) virus?

As of August 24, 2020, the jury is out on your question--Can the replication and transmission of the SARS-CoV-2 (2019-nCoV) virus in humans be inhibited in a similar way by the use of oseltamivir? It ...
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2 votes

Can oseltamivir shorten the duration of COVID-19 and inhibit replication and transmission of the SARS-CoV-2 (2019-nCoV) virus?

This drug is not one of the candidates for the WHO mega study "Solidarity" nor do I see it in any other prospective trial. Without trial data your question can not be answered. WHO and partners ...
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  • 13.2k
2 votes
Accepted

For the people who are treated with interferons, does this provide them extra protection against corona virus?

No one knows. It’s possible, and there are clinical trial underway to determine any effect eg https://www.bbc.co.uk/news/health-52504409
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  • 316
2 votes

How effective is oseltamivir when given before symptoms of flu appear?

As soon as a virus is replicating effective antiviral drugs can hamper or even prevent its progression. This principle is used for Pre-exposure prophylaxis, and more like in this case in question in ...
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  • 6,757
1 vote

For Varicella zoster (chicken pox), when are vaccination/antiviral drugs effective?

According to the World Health Organization Administering the vaccine up to 3-5 days after exposure has been shown to reduce the severity of the disease significantly, but studies vary greatly as to ...
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  • 1,970
1 vote

Could the Cuban coronavirus antiviral be a mass cure for COVID-19?

All interferons interfere with viral replication but until the Cubans show that their drug Interferon alpha 2B is any better than anything else, then there's nothing to recommend it over anything else ...
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  • 13.2k
1 vote
Accepted

Continuing effectiveness of anti-viral drugs after shingles outbreak

In, shingles, pain commonly persists after rash disappearance and usually disappears on its own. If the pain lasts for more than 30-90 days after rash disappearance, it is called postherpetic ...
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