11
votes
Accepted
Why should males use contraception for longer after taking molnupiravir for COVID?
The mechanism of action of molnupiravir is "lethal mutagenesis" (see Malone and Campbell, 2021) - it interferes with the viral RNA polymerase by introducing copying errors severe enough that ...
- 13.7k
8
votes
Accepted
What is the meaning of "co-formulated"?
From Chauhan, V. M., Zhang, H., Dalby, P. A., & Aylott, J. W. (2020). Advancements in the co-formulation of biologic therapeutics. Journal of Controlled Release, 327, 397-405.:
Co-formulation can ...
- 13.7k
6
votes
Accepted
How is Lopinavir + Ritonavir expected to stop COVID-19?
The NEJM editorial that accompanied that issue says:
One antiviral-drug candidate is a combination of the HIV protease inhibitors lopinavir and ritonavir. Lopinavir, which acts against the viral 3CL ...
- 5,968
3
votes
Accepted
Was KP-1461 found to be not a good drug?
From Mullins, J. I., Heath, L., Hughes, J. P., Kicha, J., Styrchak, S., Wong, K. G., ... & Parkins, J. (2011). Mutation of HIV-1 genomes in a clinical population treated with the mutagenic ...
- 13.7k
3
votes
(Why) are there so few studies of ivermectin as an antiviral in animal models?
First, we should focus on "ivermectin plus covid19 or a virus that mimics covid19.
For now, the FDA recognizes ivermectin as an antiviral drug. Therefore, the comparison should be "antiviral ...
- 475
2
votes
Accepted
Can oseltamivir shorten the duration of COVID-19 and inhibit replication and transmission of the SARS-CoV-2 (2019-nCoV) virus?
As of August 24, 2020, the jury is out on your question--Can the replication and transmission of the SARS-CoV-2 (2019-nCoV) virus in humans be inhibited in a similar way by the use of oseltamivir? It ...
- 975
2
votes
Can oseltamivir shorten the duration of COVID-19 and inhibit replication and transmission of the SARS-CoV-2 (2019-nCoV) virus?
This drug is not one of the candidates for the WHO mega study "Solidarity" nor do I see it in any other prospective trial. Without trial data your question can not be answered.
WHO and partners ...
- 13.2k
2
votes
Accepted
For the people who are treated with interferons, does this provide them extra protection against corona virus?
No one knows. It’s possible, and there are clinical trial underway to determine any effect eg https://www.bbc.co.uk/news/health-52504409
- 316
2
votes
How effective is oseltamivir when given before symptoms of flu appear?
As soon as a virus is replicating effective antiviral drugs can hamper or even prevent its progression.
This principle is used for Pre-exposure prophylaxis, and more like in this case in question in ...
- 6,887
1
vote
Why the FDA-approved drug label for sofosbuvir mentions "Without cirrhosis or with compensated cirrhosis" as indication?
TL;DR: No, decompensated cirrhosis is not a contraindication.
However, the safety and efficacy of Sovaldi have not been established in patients with decompensated cirrhosis:
Hepatic Impairment
No ...
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1
vote
What is the meaning of "co-formulated"?
There is currently no evidence available on the effectiveness of concurrent use of monoclonal antibodies or antivirals for Covid-19, except when co-formulated.
As they have used or, I think they are ...
- 642
1
vote
For Varicella zoster (chicken pox), when are vaccination/antiviral drugs effective?
According to the World Health Organization
Administering the vaccine up to 3-5 days after exposure has been shown to reduce the severity of the disease significantly, but studies vary greatly as to ...
- 2,013
1
vote
Could the Cuban coronavirus antiviral be a mass cure for COVID-19?
All interferons interfere with viral replication but until the Cubans show that their drug Interferon alpha 2B is any better than anything else, then there's nothing to recommend it over anything else ...
- 13.2k
1
vote
Accepted
Continuing effectiveness of anti-viral drugs after shingles outbreak
In, shingles, pain commonly persists after rash disappearance and usually disappears on its own. If the pain lasts for more than 30-90 days after rash disappearance, it is called postherpetic ...
- 15.8k
Only top scored, non community-wiki answers of a minimum length are eligible