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No, they do not contain the same active ingredient. Benadryl (trade name) is also known as diphenhydramine (generic name); loratidine (generic name) is also known as Claritin (trade name). Both drugs are primarily antihistamines and primarily active antagonists at the H1 subtype of histamine receptor. It is this property that makes them effective for ...


11

First generation H1-antihistamines (such as diphenhydramine = Benadryl) are well known for their sedative effects explaining their limited use in patients with allergic rhinitis. Several pharmacological studies have shown that diphenhydramine crosses the blood brain barrier and produces CNS sedation. Two studies have (partly) addressed your question ...


5

It means that the receptors are blocked forever. A cell is a living thing, continuously producing new proteins (including receptors) and recycling old ones. So the cell is not defective forever, it will slowly phase out its blocked receptors and replace them with new ones. You can read the basics of the way receptors work in textbooks on cell signalling, ...


4

Yep. Try spoiled fish. Histamine Poisoning (Scombroid Fish Poisoning): An Allergy-Like Intoxication Histamine poisoning results from the consumption of foods, typically certain types of fish and cheeses, that contain unusually high levels of histamine. Spoiled fish of the families, Scombridae and Scomberesocidae (e.g. tuna, mackerel, bonito), ...


3

The most common side effect of loratadine is headache which has been reported in up to 12 percent of users. Other common side effects include drowsiness occurring in 8 percent of users, fatigue in 4 percent and dry mouth in three percent. Drinking plenty of water while your dose is in effect can help alleviate these symptoms. Some who use loratadine ...


3

On histamine: Histamine causes vasodilation, not vasoconstriction. The amount of histamine blocking agents ingested largely will not counteract the whole effect of histamine, however it may prevent more pronounced side effects that are not appreciated. One of these side effects, by vasodilation and vascular leak is edema. Edema can produce pressure on ...


2

Bismuth subsalicylate and antihistamines have different mechanisms of actions, so one drug is appropriate for some and another for other conditions with nausea. Bismuth subsalicylate can "soothe" the gut by being a mild anti-inflammatory, antacid, antibiotic and anti-diarrheal, so it can reduce nausea and diarrhea in gastrointestinal conditions, for example,...


1

Benadryl (aka diphenhydramine) is strongly anticholinergic1. That means it blocks acetylcholine activity in the body's cells. It does this by binding with the cells' acetylcholine receptors, which just about all cells have. These drugs have been linked to dementia2 in older people. Among the H1-blocking antihistamines (loratadine [Claritin], cetirizine [...


1

I’ve found a quotation that sheds some light on the topic: The rate of termination of the action of a reversible antagonist is largely dependent on the half-life of the drug as well as the rate at which it dissociates from its receptor: the shorter the half-life, the less time it takes until the effects of the drug are dissipated. However, the ...


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