4 votes
Accepted

Anorgasmia with SSRI and SNRI prescriptions

First of all, anorgasmia can be either a primary effect caused by depression itself, along with decreased libido. But then it may also be a side-effect of the medication itself, adding to the ...
  • 6,797
3 votes

How long do you have to take an SSRI for before PSSD becomes a risk?

This is currently impossible to answer definitely. There is further a difference between 'could become a risk' and 'will likely be a risk'. Only now are even the warnings about the long established ...
  • 6,797
3 votes

Can/In what way does Vortioxetine/Brintellix treat ADHD?

First, a correction. ADHD is NOT caused by a dopamine deficiency. It is way more complex than that, but i won't go into detail here. The best treatments for ADHD alter dopamine activity (and they are ...
  • 31
3 votes
Accepted

Is cannabidiol safe to treat depression of a patient with a schizoaffective disorder?

First of all, you have to be aware that most studies cited are on animals, not humans. Applicability of that data for humans is limited. Second, this molecule is interacting with all kinds of tissues ...
  • 6,797
2 votes
Accepted

Why is Tradozone prescribed to aid with insomnia?

Pharmacology: Inhibits reuptake of serotonin, causes adrenoreceptor subsensitivity, acts as a 5HT2a receptor antagonist and induces significant changes in 5-HT presynaptic receptor adrenoreceptors. ...
2 votes

Antidepressant response post MAOI tachyphylaxis

All Anti-Depressants poop out equally for TR patients. Having just now signed up on this site, it seems a prerequisite to post is that you ought to have at least minimally researched the question, ...
2 votes

How does vortioxetine cause nausea when it inhibits 5HT3-receptors?

Its primary action is as NaSSA (a noradrenergic and specific serotonergic antidepressant), not as 5-HT3 inhibitor. If you have a look at e. g. the Wikipedia page (https://en.wikipedia.org/wiki/...
  • 1,153
1 vote

How does vortioxetine cause nausea when it inhibits 5HT3-receptors?

I was mistaken, the 5HT3 inhibitor of Vortioxetine is not responsible for the nausea, see here Its additional antagonism of 5-HT3 receptors may partly counteract gastrointestinal adverse effects but ...
  • 151
1 vote

Long term use of St Johns wort

The main use of St John's Wort is for depression but there are supposedly other uses (WebMD, n.d.) which may or may not work. The only study I can find on the effectiveness of St John's Wort against ...
  • 5,911

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