Questions tagged [vaccination]

treat with a vaccine to produce immunity against a disease; inoculation.

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How fast could mRNA COVID manufacturers switch from the Wuhan strain to e.g. B.1.1.7 and why?

I understand that the time it took Modena to go from the SARS-CoV-2 sequence to shipping doses for clinical trial was 44 days: https://www.modernatx.com/modernas-work-potential-vaccine-against-covid-...
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How does the type of syringe impact the number of doses of Corona vaccine available per vial?

In an interview with Ron Klain (Biden's Chief of Staff) on CNN this morning, it was suggested that Biden would invoke the National Defense Production act to increase the production of syringes that ...
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Will getting a vaccine have any additional effect on your immune system if you already got covid-19?

Supposedly people who got covid-19 get immunity after it. According to this article, More SARS-COV-2 reinfections reported but still a rare event citing several studies, Bertollini and his colleagues ...
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Are “some serious side effects and deaths expected” from a mass vaccination campaign of a new vaccine?

According to What is known so far about the post vaccination deaths in Norway Medical director Steinar Madsen stated, Q: Were these problems unexpected? A: No. A mass vaccination campaign by ...
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Why does the Pfizer’s Covid vaccine cause more intense intense symptoms after second shot then after the first shot?

cnbc.com (mirror) mentions: The FDA says Pfizer’s Covid vaccine is safe and effective. But trial participants warn of intense symptoms after second shot. Why does the Pfizer’s Covid vaccine cause ...
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How can vaccines be effective against respiratory viruses when it is the innate immune system that is the primary response to such pathogens?

I don't understand how vaccines can be thought to be effective against respiratory viruses. We have influenza "vaccines" and now the new mRNA vaccine against COVID-19. However, my ...
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Are there vaccines that are safe to use in adults, but harmful in children?

I've recently read an article mentioning how vaccine companies are enrolling children to test if their vaccines work on kids too. But is this just a theoretical concern or is there historical ...
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Is the code from the mRNA vaccine executed by the cells as a one-off? [closed]

Is the code from the mRNA vaccine executed by the cell that has taken it up as a one-off or does the cell produce the spike proteins endlessly (like a programming loop) until the cell is killed by the ...
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Why do some vectored vaccine makers rely on 1-jab only for their Covid-19 vaccines?

While some of the medical companies like AstraZeneca and Russian Gamaleya, which use a vectored approach for their Covid-19 vaccines, choose a two-jab schedule, the others like CanSino and J&J ...
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Are all ad5 vector vaccines (including COVID19 potential vaccines) really dangerous in terms of higher risk of getting HIV? [closed]

I'm currently living in a country where people can count only on ad5-vector based vaccines against Covid19 in the near future. Making up my mind about getting such jab, I came across several ...
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One covid vaccine must be stored at -70 degrees Celsius [duplicate]

One covid vaccine must be stored at -70 degrees Celsius. What type of substance or mechanism ensures that the structure of the virus mRNA elements is not distorted at this temperature? And why does ...
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What does it mean for a vaccine to be “90% effective”? [duplicate]

It seems like a stupid question: does it "just" mean that 90% of the population won't be infected? But if only 10% of the population would have been infected without the vaccine, then it's ...
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Could the COVID-19 vaccine adversely impact healthy protein reception?

I'm not a health expert, just trying to understand possible long-term side effects of the vaccine, so if my terminology and thinking is off, feel free to correct. The prominent vaccines right now are ...
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CDC COVID Vaccine Administration Time Series Data?

For context, in the past the CDC has published time series data of COVID case counts by State: https://healthdata.gov/dataset/united-states-covid-19-cases-and-deaths-state-over-time Now, CDC are ...
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For fighting COVID19, Why we give the body the RNA and not give the body the protien itself? [duplicate]

If I understand things correctly the popular COVID 19 vaccine gives the body RNA that teaches the body cells to create a protein that looks like the virus. And then the body learns to fight against it....
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Is there a disease where having had the disease provides less protection for the future than the vaccination?

Vaccination makes sure that you have anti-bodies so that your immune system has a heads-start once you get infected. If you were infected before, your body also built anti-bodies. Are there diseases ...
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Don't mRNA vaccines (Pfizer and Moderna) cure COVID patients? [closed]

I went through the below Twitter thread on how mRNA vaccines (Pfizer and Moderna) work. https://twitter.com/WheatNOil/status/1339624815137722368 As per that, these vaccines prepare our body to fight ...
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Which regimen of the AstraZeneca vaccine was approved (in UK and India respectively)?

The Oxford-AstraZeneca made furore two months ago for a dosage error in its 3rd phase trial. The 3000 or so trial participant who got the regimen with the erroneous dosage, showed apparent greater ...
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(Why) doesn't Moderna's Covid vaccine have an INN?

Pfizer's and even more obscure mRNA vaccines that haven't been approved have an INN, which ends with -meran (e.g. CureVac's is "zorecimeran"). But as far as I can tell Moderna's vaccine ...
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BNT162b2 mRNA Covid-19 Vaccine efficacy after 1st dose - explain the statistics

Pfizer's paper (Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine) published recently states the following in the Efficacy subsection of the Results section: Between the first dose and the ...
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Why do adults need vaccination boosters? [duplicate]

In the UK at the moment there's some controversy regarding the changing of the timing of the Covid vaccination boosters. All the vaccines I can think of that need boosters are given to babies, whose ...
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Why Herpes Vaccine Hasn't Been Discovered Yet While Corona Vaccines Find Its Way Within A Year? [closed]

There is one question constantly running in my mind: how were COVID-19 vaccines discovered in a very short time span, but Herpes did not find its way even after years of painstaking research?
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Is there a benefit of a COVID-19 vaccination if one had COVID-19 before?

I see the clear benefit of the vaccination if one didn't have the disease. However, there are a lot of people who had the disease already. So I assume they also have the anti-bodies? Or is this a ...
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Will the COVID-19 vaccine grant immunity to other coronaviruses?

As I understand it, the mRNA vaccine teaches the immune system to recognize and attack the spike protein on the surface of the novel coronavirus. Don't all coronaviruses share this same spike protein? ...
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Long-term side effects of anti-covid vaccines

I am interested in statistical procedures and study designs used to determine the absence/acceptability of long-term side effects of the anti-covid vaccines. Given that these vaccines were created and ...
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Why is the new mRNA vaccine unable to modify human DNA?

One of the most common worries expressed against the new coronavirus vaccine is that, supposedly, injecting mRNA into a cell has the potential to alter the human genome. I am constantly bombarded by ...
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Are there any educated guesses related to the type and probability of severe side effects caused by the COVID-19 vaccines?

Multiple countries have already started the COVID-19 vaccination. Local media covered this extensively and I saw that many medical doctors and researchers arguing that the vaccines are very safe ...
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Details on “Health Impact Events” on V-safe Active Surveillance for COVID-19 Vaccines

Some dubious websites (which I won't link) are claiming that COVID-19 vaccine caused disabilities in more than 3.000 people. As a support of this claim, they cite the table "V-safe Active ...
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Why does the Pfizer vaccine need storage at -70C but Moderna's only needs -20C, when they are both mRNA vaccines?

It's been widely reported in the press that Pfizer's vaccine needs storage at -70C but Moderna's only needs -20C. Why is this so, when they are both mRNA vaccines? There's actually a looong article in ...
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How do mRNA vaccines work and what are their advantages over traditional vaccines?

How do mRNA vaccines work? To my intuitive understanding, for an mRNA vaccine to work, the mRNAs injected into the patient need to first enter a cell and get translated into proteins. Those proteins ...
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How can we realistically vaccinate our way to herd immunity?

So I've been keeping track of the number of people have received a vaccine for COVID-19 in the US. If we want to vaccinate 70%-90% of the population, per latest Dr. Fauci's estimates, then we need to ...
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What are some mRNA vaccines, other than COVID vaccines, that are widely used?

From what I've read, COVID vaccines belong to mRNA vaccines category. I read in the above article that mRNA vaccines act in a different way than traditional vaccines. [..]Traditional vaccines ...
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How do pharmaceutical companies deal with people who received a placebo?

I would like to know what happens to the people in the vaccine studies who received a placebo. Essentially they have not been vaccinated. However, in order for the study to stay blind so that long ...
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How long would societal restrictions be in place if a COVID-19 vaccine has upward of 90% effectiveness? [closed]

Background Back in October, Dr. Fauci said that the United States will need societal restrictions potentially until the beginning of 2022 according to WebMD: Coronavirus vaccines -- once approved and ...
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How can a vaccine prevent an individual from getting a disease but not from transmitting it?

In the news about the COVID-19 vaccines which are about to begin distribution, I've seen statements to the effect that "it’s not clear if the shot keeps the disease from being transmitted" (...
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Why use sucrose rather than glucose in an injectable vaccine?

These are the ingredients of Pfizer-BioNTech COVID-19 vaccine: Medicinal: mRNA Non-medicinal: ALC-0315 = ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate) ALC-0159 = 2-[(...
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Covid vaccine side effects [closed]

The Pfizer Covid vaccine caused allergic reactions. For patients that are deemed to be at an increased risk of adverse side effects following a risk assessment (e.g. because of diabetes, heart disease)...
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How come moderna vaccine can last at much more much higher temperature than Pfizer's vaccine?

I've read recently that Moderna's vaccine for covid-19 can last at around 60 degree more than Pfizer's. My question is why, given that they both use the same technique? references: https://...
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Is there a reason to be anxious about claim that COVID-19 vaccine could turn out to be inducing infertility in females?

There is a petition written on December 1, 2020 to European Medicines Agency (EMA) by Dr. med. Wolfgang Wodarg and Dr. Michael Yeadon. You can see it here. Both of them are well known for spreading ...
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Have there been vaccines in the past, which revealed side effects only after extended periods of times? [duplicate]

Obviously we don't have precedent for mRNA vaccines like the now available SARS-CoV-2 vaccine from German-American Joint Venture Biontech/Pfizer. But how about the other, more conventional vaccine ...
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Are there vaccines which have a varying effect on people of different ethnicities?

As per the New York Times: Moderna’s problem seemed fitting for late summer 2020, when the United States was reeling from not just a pandemic but unrest over racial injustice. Dr. Slaoui informed Mr. ...
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Can an individual who has had a covid-19 vaccination test positive and is that a problem?

Can an individual who has had a covid-19 vaccination test positive and is that a problem? Up to now and for some time to come, testing has been important to help control the spread of this disease. ...
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Does being vaccinated prevent transmission of disease if you catch it

Each year, many people get the flu vaccine (and I'm sure there are many more other than flu). Even if you get this vaccine, and from what I've understood, you can still catch the same strain of flu as ...
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What percentage of vaccines are deemed unsafe at which stage in the testing?

What percentage of vaccines are deemed unsafe at what stage of the testing? Is it common that vaccines reach stage 2 for example and are deemed unsafe there? What about vaccines making it to stage 3? ...
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Necessity of flu shots under pandemic living conditions [closed]

Is the following logic valid? Getting an influenza vaccine is less necessary this season, if one is going to live under conditions (mask-wearing, drastically reduced contacts with others etc) designed ...
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Are there independent studies on the efficacy of vaccines?

Is there a collection, meta analysis or review of significant, independent studies that prove the efficacy of vaccinations? I am in discussion with a anti-vaccinationist who claims that the efficacy ...
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COVID19 Vaccine Clinical Trials

I am interested in learning about the details of the Phase 3 clinical trial designs for the Moderna, Pfizer/Biotech, and AstraZeneca/Oxford vaccines. I expect that the trial designs would be published ...
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RNA vaccination and autoimmune reactions

to my knowledge we do not have any robust experience with RNA vaccination. Most likely this will change in the near future as RNA vaccines against COVID are in the pipline. The rational behind this ...
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What does “pause” mean in Covid19 Vaccine Clinical Trials?

Johnson and Johnson as well as Astra Zeneca recently announced that they were going to "pause" in their respective clinical trials for a Covid19 vaccine. What exactly are they "pausing&...
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Does an hpv vaccination still make sense after age 26?

The US CDC says that an HPV vaccination is recommended up to the age of 26. If you are older than that and not infected yet, why shouldn't it make sense to get vaccinated then?