Questions tagged [vaccination]

treat with a vaccine to produce immunity against a disease; inoculation.

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Any known case reports of inadvertent i.v. administration of an adenovirus-based vaccine?

In connection with another question here (which discusses the theory that TTS effects in [Covid-19] adenovirus-based vaccines are due to i.v. administration error) let met ask: are there any known ...
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Were thrombocyte counts or bleeding events monitored at all during ChAdOx1 (AZD1222) clinical trials?

Maybe I'm just missing something, but on a quick look, I find it a bit strange that since issues with thrombocyte (platelet) counts in adenovirus-vectored therapeutics have (1) been known for about ...
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Is the decrease in vaccine uptake in the US for two weeks in a row in line with some models' expectation?

According to Reuters news of May 3, vaccinations have also fallen in the US for two weeks in a row. Nationally, deaths from COVID-19 fell 3% to 4,819 in the week ended May 2, the fewest deaths in a ...
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Would it be okay to have the Astrazeneca vaccine if I had dengue hemorrhagic fever as a child? [closed]

Although it happened more than two decades ago, I still remember being very ill, vomiting so much blood at one point. I was given an IV drip and had to stay in hospital for a while. Would having had ...
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What is the historical or scientific basis for concern about COVID vaccines and pregnant women and their babies?

There's a lot of talk about whether COVID vaccines are safe for pregnant women and their fetuses. Current guidelines, while mentioning that there's little data, suggest that they are safe. However, I'...
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How long should I wait before taking Covid -19 vaccine after Shingles infection? [closed]

I am a healthy 54 year old female with no known illnesses. I was diagnosed with shingles (on my face) on April 10th, 2021 and I was on a 14 day course of anti viral drugs (10th April till 24th April) ...
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When speaking of vaccine efficacy (for COVID-19, or other), is immune response or efficacy really being measured? [duplicate]

I've been performing many web searches using combinations of the words "vaccine", "vaccination", "COVID-19", "coronavirus", "efficacy", and "...
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Covid-19 and Original Antigenic Sin

My understanding of original antigenic sin, which I admit is minimal, is that with some pathogens, your immune system gets too focused on one variant and thus is wholly unprepared to deal with a ...
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Why does my volunteering with kids mean I should get a tetanus shot?

I volunteer with kids a decent amount. A little while ago my doctor recommended that I get the tetanus shot specifically due to the fact that I spend so much time around small children. At the time I ...
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Is there evidence that vaccine-related blood clots could be due to injection technique?

Recently, Danish health authorities including Denmark's SSI issued new guidelines for intramascular vaccination to be done with aspiration, in case some of the vaccine-induced blood clot cases are due ...
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Is there any data on herbal supplements interfering with the efficacy of vaccination?

Here's an excerpt from a paper published in "Journal of Inflammation Research" by Dove Press for a popular and controversial herbal supplement from India: Coronil effectively inhibited the ...
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On Td/Tdap Vaccine requirement

I'm given a vaccine requirement form. I have problem understanding the following requirement: Td/Tdap: YES, substitute 1-time dose of Tdap for Td booster; then boost with Td every 10 years On my ...
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Where can I find up-to-date information on the vaccine efficacy for different COVID-19 variants and the main COVID-19 vaccines?

I have a list (sent to me by email). I wonder if there exists some up-to-date information on the vaccine efficacy for different COVID-19 variants and the main COVID-19 vaccines (e.g., similar to COVID-...
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what does 95% effectivenes mean for vaccines (covid) [duplicate]

Often we see in news they say AstraZeneca is 95% effective, while Chinese vaccine is 50%. I have question how to interpret these numbers. Does this mean that if you get vaccinated with AstraZeneca ...
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What are the “theoretical risks” of COVID vaccines in mothers

In Germany, there is no official endorsement of COVID mRNA vaccines for pregnant women and nursing mothers due to a lack of study data. Still, professional societies generally recommend considering ...
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Why is it so difficult to develop vaccine for HIV?

I recently learnt that vaccine basically involves making the body ready by informing it the structure of spike protiens the virus has before hand. Why are we not able to do this for HIV. What's so ...
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Why have so few people received a second dose of the vaccine COVID-19 in India?

From https://www.google.com/search?q=india+covid+cases&oq=india+covid+cases: Why have so few people received a second dose of the vaccine COVID-19 in India? I've searched for "india second ...
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How does the thrombosis risk of COVID compare to that of the vaccines?

There was some news, possibly based on this paper, that the risk of thrombosis caused by COVID-19 is supposedly 10 times higher than that of "vaccination". To me this conclusion seems flawed ...
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Which covid-19 vaccines have suspected cases of thrombosis?

As far as I know, Astrazeneca, Moderna, Pfizer and Johnson & Johnson have suspected cases of thrombosis. U.S. Recommends Pausing Use Of Johnson & Johnson Vaccine Over Blood Clot Concerns ...
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Is there a vaccine product containing Mumps orthorubulavirus and Rubella virus antigens without any other immunizing components?

Is there a vaccine product containing Mumps orthorubulavirus and Rubella virus antigens without any other immunizing components? Or asked differently: Is there a vaccine product against mumps and ...
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Is there a free vaccine or medicinal product database?

Is there a database that allows me to query for available vaccine products by ingredients? For instance, I want to find an available vaccine product that contains "Streptococcus pneumoniae ...
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Is there any study on the efficacy against hospitalizations of the first dose of the Sputnik V vaccine?

For the Sputnik V vaccine there has been a study about the efficacy of the vaccine 2 doses which states it has 91.6% efficacy against infection and a 100% efficacy against hospitalization. Sputnik V ...
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Are coronavirus-like spikes only seen in viruses?

Are there any natural proteins or cells (or anything) made by the human body with spikes like those of Covid-19? I know that there have been no serious side effects reported from the Covid-19 vaccine, ...
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How is the decision for recommending a vaccine reached

There is an ongoing discussion about the use of the AstraZeneca covid-19 vaccine (Vaxzevria) in Europe. Some countries like Germany restrict the use of this vaccine, some - like Austria - do not. How ...
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Meaning of vaccine effectiveness? [duplicate]

We see figures like "ACMECorp covid vaccine is 90% effective". I guess that this means something like: In the trial the number of people receiving the vaccine who caught covid is only 10% ...
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Why do phase I [vaccine] trials [normally] last several months if [on average] they can't find any serious adverse effects?

Let me ask a "devils' advocate" question that hopefully clarifies a point on another popular (for some reason) question here: We can read for example (in a meta-analysis that's not even ...
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Can vaccines cause side effects that the virus itself will not cause? [closed]

The COVID vaccines have reignited the discussion about vaccines’ potential side effects. While we all know these are extremely rare, I would like to understand how they are even possible at all. A ...
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Covid19 Rapid serological tests and Vaccine

Let's say that once I'm vaccinated I try the rapid serological test and the result is negative. My question is: let's admit that the reliability of the test is 100%; does it mean that the vaccine didn'...
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Why wouldn't the Pfizer, Moderna, AstraZeneca, and Johnson & Johnson vaccines be equally effective?

Based on what I have read, the Pfizer, Moderna, AstraZeneca, and Johnson & Johnson COVID-19 vaccines all work by training the immune system to recognize the spike protein on the surface of the ...
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How are two-dose vaccine schedules developed?

How are vaccination schedules determined for multi-dose vaccines? That is, are several different schedules tested in an early-phase trial? Or do the developers of a vaccine choose a schedule (based on ...
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Are Covishield and AstraZeneca AZD1222 the same?

Some sources simply equate the two. On the other hand, Covishield seems to be undergoing its own clinical trials. The statement by the Indian authorities calls it “Recombinant Chimpanzee Adenovirus ...
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Might the lack of Flu this year cause a problem creating next years flu vaccine?

According to this article, the UK lockdowns have had the effect of virtually eliminating Flu. As most of Europe/ The World has seen similar lockdowns, my expectation is that this would be reflected in ...
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UPDATED Why is the new viral vector vaccine unable to modify human DNA?

UPDATE: Adding additional information after digging around. First, I am not a medical professional. I found this article studying the rates of DNA integration via adenovirus vectors in mice, ...
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COVID-19 vaccination second doses: why two doses and why the specified interval?

Certain COVID-19 vaccines such as the Pfizer BioNTech and Moderna are specified to be administered in two doses separated by a 21 and 28 day interval, respectively. My questions are: Why administered ...
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How durable is a human immunity to an adenovirus (at least specific serotypes)?

There are few SARS-Cov-2 vaccines that use adenovirus vectors as vehicles (human's Ad5, Ad26, chimps' ChAdOx1, probably something else). A side effect of such a vaccine is that an inoculated organism ...
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Can COVID-19 vaccines cause birth defects?

Have regulators historically allowed enough time for Phase 3 trials to show that a vaccine does not cause congenital defects? Are they making an exception for Covid vaccines? Because the Pfizer/...
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Acetaminophen and/or ibuprofen before or after vaccination

All of a sudden (yesterday apparently) there blossomed on the major news outlets an admonition not to take either Tylenol or Advil prior to and or immediately after Covid-19 vaccination. The logic ...
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Frequency of reactions to Covid19 vaccinations

Facebook is replete with comments that 'the aftermath of the second Moderna vaccine shot was wicked', 'hit me much harder than the first' etc Understanding that many facebook postings are unreliable ...
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How much potency is lost by the end of a vaccine shelf life?

I've been researching various approaches to modelling vaccine shelf life, using Arrhenius or Q10 equations to give broad estimates. I've also looked at more complex two-step equations. What puzzles me ...
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How well are the covid-19 vaccines doing in the field?

By now, millions of people have been given the Pfizer and Moderna vaccines in the US, and the same is true for those and other vaccines in many other countries. I have not found in the media any news ...
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How fast could mRNA COVID manufacturers switch from the Wuhan strain to e.g. B.1.1.7 and why?

I understand that the time it took Modena to go from the SARS-CoV-2 sequence to shipping doses for clinical trial was 44 days: https://www.modernatx.com/modernas-work-potential-vaccine-against-covid-...
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Are there vaccines that are safe to use in adults, but harmful in children?

I've recently read an article mentioning how vaccine companies are enrolling children to test if their vaccines work on kids too. But is this just a theoretical concern or is there historical ...
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Are “some serious side effects and deaths expected” from a mass vaccination campaign of a new vaccine?

According to What is known so far about the post vaccination deaths in Norway Medical director Steinar Madsen stated, Q: Were these problems unexpected? A: No. A mass vaccination campaign by ...
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Why does the Pfizer’s Covid vaccine cause more intense intense symptoms after second shot then after the first shot?

cnbc.com (mirror) mentions: The FDA says Pfizer’s Covid vaccine is safe and effective. But trial participants warn of intense symptoms after second shot. Why does the Pfizer’s Covid vaccine cause ...
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How does the type of syringe impact the number of doses of Corona vaccine available per vial?

In an interview with Ron Klain (Biden's Chief of Staff) on CNN this morning, it was suggested that Biden would invoke the National Defense Production act to increase the production of syringes that ...
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Is the code from the mRNA vaccine executed by the cells as a one-off? [closed]

Is the code from the mRNA vaccine executed by the cell that has taken it up as a one-off or does the cell produce the spike proteins endlessly (like a programming loop) until the cell is killed by the ...
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How can vaccines be effective against respiratory viruses when it is the innate immune system that is the primary response to such pathogens?

I don't understand how vaccines can be thought to be effective against respiratory viruses. We have influenza "vaccines" and now the new mRNA vaccine against COVID-19. However, my ...
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Why do some vectored vaccine makers rely on 1-jab only for their Covid-19 vaccines?

While some of the medical companies like AstraZeneca and Russian Gamaleya, which use a vectored approach for their Covid-19 vaccines, choose a two-jab schedule, the others like CanSino and J&J ...
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One covid vaccine must be stored at -70 degrees Celsius [duplicate]

One covid vaccine must be stored at -70 degrees Celsius. What type of substance or mechanism ensures that the structure of the virus mRNA elements is not distorted at this temperature? And why does ...
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What does it mean for a vaccine to be “90% effective”? [duplicate]

It seems like a stupid question: does it "just" mean that 90% of the population won't be infected? But if only 10% of the population would have been infected without the vaccine, then it's ...

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