Questions tagged [sars-cov-2]

SARS-CoV-2 is the scientific name given by the International Committee on Taxonomy of Viruses to the virus that causes the disease Covid-19 or coronavirus disease 2019.

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25
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2answers
4k views

Would the human seasonal coronaviruses be just as deadly as COVID-19 in a population with no prior immunity?

Presuming that we were able to find a person who was never exposed to any of the human seasonal coronaviruses (part of the viruses that cause the common cold), would the virus be just as deadly for ...
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If a SARS-CoV-2 asymptomatic infected individual is exposed to a high viral load, could they develop COVID-19 disease?

I would add my own research if I could to respect site rules, but I can't. There are no studies on SARS-CoV-2, all I can find is for SARS-CoV-1 and some Chinese information based studies. My ...
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Why isn't COVID-19 just called SARS-2? Isn't it a second SARS? [duplicate]

Severe Acute Respiratory Syndrome (SARS) is a disease caused by SARS-CoV—the "SARS CoronaVirus". We now have a second disease caused by a second coronavirus, which we call SARS-CoV-2. So why ...
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How is Lopinavir + Ritonavir expected to stop COVID-19?

There are four drugs being tested for effectiveness against COVID-19 in the SOLIDARITY trial. Three of them have obvious potential mechanisms of action: Remdesivir is an RNA polymerase inhibitor. ...
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Is there a reason to be anxious about claim that COVID-19 vaccine could turn out to be inducing infertility in females?

There is a petition written on December 1, 2020 to European Medicines Agency (EMA) by Dr. med. Wolfgang Wodarg and Dr. Michael Yeadon. You can see it here. Both of them are well known for spreading ...
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Why is developing a SARS-CoV-2 vaccine expected to take longer than developing the 1957 flu vaccine?

Maurice Hillman developed a vaccine for the 1957 flu pandemic that was ready within five months (1). One commonly hears that it will take at least 12-18 months in total to deploy a vaccine against ...
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Can SARS-CoV-2 be a potential cause for Guillain-Barré syndrome?

According to Wikipedia :- ...Although the cause is unknown, the underlying mechanism involves an autoimmune disorder in which the body's immune system mistakenly attacks the peripheral nerves and ...
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1answer
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How long can SARS-CoV-2 persist on surfaces?

We are seeing different values for how long this virus can persist on surfaces with the more recent data suggesting: copper 4 hours, plastic & stainless steel 3 days and, other studies stainless ...
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What's the fastest COVID-19 test available?

This video 1 minute COVID-19 test talks about a 1 minute COVID-19 testing which isn't available to the public yet. In the market and online, you can find fast COVID-19 tests which deliver the result ...
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Are there reliable studies on the viability of the SARS-CoV-2 virus with respect to temperature?

There have been "suggestions" (facebook, media etc) that the novel coronavirus is heat sensitive. Specifically that the virus is "killed" or impotent when subjected to temperature of 77F. Are there ...
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What data is there for physicians to advise patients taking Ace Inhibitors during the COVID-19 pandemic?

Angiotensin-converting enzyme 2 (ACE2) is a membrane-bound aminopeptidase that has a vital role in the cardiovascular and immune systems4. ACE2 is involved in heart function and the development of ...
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641 views

How mutable is SARS-CoV-2 virus?

As it commonly known, mutability is a fundamental characteristic of viruses which presents the ability of virus genome to adapt to physical circumstances, prevent and circumvent vaccine effect and to ...
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Would a SARS-CoV-2 infection disrupt the blood-brain barrier, leaving the brain more vulnerable to drugs taken simultaneously with the infection?

According to some studies[1], there is some evidence that the virus could cross the BBB. Is that is the case, does that mean that it would weaken the barrier allowing potentially neurotoxic drugs to ...
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1answer
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Why are government decisions being led by the number of COVID CASES (as opposed to actual deaths)? [closed]

Since the early days of COVID-19, when very little information was available regarding this new virus, we now have an abundance of data. Data such as: Cases recorded, per nation, per time period ...
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Why are Novel Coronavirus anitbody tests disparaged?

The Novel Coronavirus antibody test has been around since February 2020 when it was invented at a Chinese University. It can measure both IgM to show infection in progress and IgG to indicate full ...
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1answer
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What information we have about transmission of COVID-19 in detail?

A lot of information we have how the COVID-19 virus spreads in general. But what do we know about the detected and proven way of transmission: about which items (door handles, plates, salad bar, ...) ...
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What does it mean to say a population has “low levels of general immunity”?

The UN Humanitarian Coordinator in Yemen, Lisa Grande, is quoted in several places (e.g. this CBS news article as saying (emphasis mine): [SARS-CoV-2] is now in Yemen and may quickly spread. […] ...
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Why did COVID-19 spread so much faster than H1N1/09 in China?

Despite China's success in controlling the COVID-19 outbreak insofar, a March 31 Science paper that analyzes the response has this intriguing (and alarming) observation The dispersal of COVID-19 ...
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1answer
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Are Covishield and AstraZeneca AZD1222 the same?

Some sources simply equate the two. On the other hand, Covishield seems to be undergoing its own clinical trials. The statement by the Indian authorities calls it “Recombinant Chimpanzee Adenovirus ...
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Is an “asymptomatic COVID-19 case” a misnomer?

I've seen references to asymptomatic COVID-19 cases, and am wondering if this is incorrect use of the term. If COVID-19 is the disease caused by the novel coronavirus SARS-CoV-2, then aren't truly ...
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1answer
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What is known about transmission of coronaviruses through food?

I've seen a lot data about COVID-19 virus (SARS-CoV-2) on dry surfaces. But what about wet mediums, in particular food? In the West, it's easy enough to disinfect supermarket packages (before opening ...
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Would “working out” with a respiratory muscle training device improve survivability of ARDS in patients without access to a ventilator?

"Acute Respiratory Distress Syndrome" (ARDS) is characterized by a rapid onset of widespread inflammation of the lungs. The causes are many, and one such cause might become prominent in the near ...
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Is it true that half of the COVID-19 patients, even seemingly without symptoms, obtain serious heart damage?

In this video, complex systems expert and physicist-turned-epidemiologist Yaneer Bar-Yam claims that according to recent findings, about half of the people that have been infected with COVID-19 will ...
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Degree of correlation between viral load and symptom severity in Covid-19?

Someone asked here a general/related (qualitative) question Does viral load of the initial infection affect its severity? but I'm interstested a more focused question regarding Covid-19: How well ...
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Why wouldn't the Pfizer, Moderna, AstraZeneca, and Johnson & Johnson vaccines be equally effective?

Based on what I have read, the Pfizer, Moderna, AstraZeneca, and Johnson & Johnson COVID-19 vaccines all work by training the immune system to recognize the spike protein on the surface of the ...
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1answer
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What are the genetic predispositions, if any, for covid-19?

What are the genetic predispositions, if any, for covid-19? For example, https://www.express.co.uk/news/science/1258244/Coronavirus-symptoms-COVID19-susceptibility-genetic-transmission-latest-...
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What is the clinical significance of the ACE2 receptor tropism of SARS-COV-2?

I understand that ACE2 functions as a receptor for SARS-CoV-2, so there are theoretical concerns to the use of ACE inhibitors as they might upregulate this receptor. This NEJM study was helpful to ...
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1answer
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Disinfecting laundry — that of a likely COVID patient, or of any other possibly-infectious individual

Clothing can probably spread fungal infections (e.g. athlete's foot) from person to person. There's not a lot of evidence that clothing can spread bacterial infections. But Bloomfield et al. quote ...
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Is the SARS-CoV-2 that causes COVID-19 the only known virus that enters the cells via the ACE2 receptors?

I am just curious if the virus is unique in the sense that it enters the ACE2 receptors in the human body and kills the cell. This receptor is located over the entire body. Is this the only virus ...
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Is it helpful for the average citizen (non medical professionals) to wear gloves and disinfect them instead of disinfecting the bare hands?

In the last months I have seen lots of articles about wearing masks and gloves to prevent the infecting yourself or others. In the case of the masks this is quite clear that we should wear them, but ...
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1answer
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False Positive PCR - COVID-19 and possible reinfection when antibodies value is +7.0

A friend of mine was detected COVID-19 positive through PCR one month back. He was asymptotic as per doctors and had no symptoms. He quarantined himself and increased his intake of water. After 1 ...
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1answer
111 views

How resistant to moist heat is SARS-CoV-2

At one of FB groups I have found the following figure: As the efficiency of disinfection methods has been tested against E. coli, I wonder, how resistant SARS-CoV-2 is? Is it safe to reuse FFP2/3 (...
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Number of subsequent infections per case / overdispersion of COVID-19

I am aware that SARS-CoV-2 shows overdispersion, that is that many infected people cause no subsequent infections, but a small number of people cause very many infections (superspreading). The best ...
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Any replications for the finding that SARS-CoV-2 disease severity depends on the initial ineffective dose?

In an October NEJM article it was stated that: Recent virologic, epidemiologic, and ecologic data have led to the hypothesis that facial masking may also reduce the severity of disease among people ...
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How effective are reused surgical masks?

Let's say I have used a surgical mask multiple times. And say I left it on a safe place, untouched, for three days which is the longest that viable SARS-CoV-2 has been found on different materials (...
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Can having other coronaviruses like HCoV-OC43 give positive results when testing for SARS-CoV-2? [closed]

Is it possible that a person having coronaviruses other than SARS-CoV-2 test positive for SARS-CoV-2 in rapid (antibody testing kits) as well as RT PCR tests? Searching around the internet didn't ...
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0answers
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Other than death, what are the potential long-term health impacts on individuals infected with COVID-19?

There is a lot of concern about deaths resulting from or exacerbated by SARS-CoV-2 infections, but I can find little about the potential long-term health impacts on those who 'recover' (understandably,...
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What is the minimal infectious dose (MID) of SARS-CoV-2?

Assuming the immune system is healthy, How much SARS-CoV-2 virus (cause of COVID-19) is required to make a person sick? This might also depend on time, if it was a high infectious dose but just some ...
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1answer
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Can mRNAs modify our DNA (publication misunderstanding)?

I am a bit confused about a publication (few month old) which seems to say that RNA can modify our DNA. The publication is the following one. Unfortunately, I am not a medical expert (and even more in ...
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3answers
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What is the principal goal in pooled COVID-19 testing?

Pooled testing for COVID-19 is being considered as a method to ramp up testing Stat News. Apparently this is being considered by the White House coronavirus team. It's not clear to me what the goal of ...
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1answer
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COVID-19: Is it possible to use the specimen collected through swabs for multiple tests

I am an engineer and currently doing some modeling of COVID-19 testing from a math perspective. I was reading through COVID-19 articles related to testing and I had the following doubt: If a ...
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1answer
88 views

What is the long-term COVID-19 outlook?

Finding a cure for the common cold has long been an unattainable holy grail of medicine. The common cold is caused by over 200 different strains of viruses (Common cold - Wikipedia). The viruses ...
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1answer
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Approximately, how much of protection one gets by using a face-mask-shield and a surgical-mask?

We know that face-mask-shield don't protect against droplet nuclei which float in the air, so one could end up infected, with COVID-19, even when wearing them. However the face-mask-shield plus a ...
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2answers
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Is there any upside of using N95 masks instead of N99 or N100 to protect against COVID-19?

One of the most commonly used masks/recommended to protect against COVID-19 is N95. Is there any upside of using N95 masks instead of N99 or N100 to protect against COVID-19? N95 which filter 95% of ...
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1answer
50 views

Are there *in vitro* studies that find ivermectin directly effective against the SARS-CoV-2 spike or its other proteins?

Among the more obscure papers proposing ivermectin as a treatment for Covid-19 there are some that suggest it acts directly by binding to the SARS-CoV-2 spike protein (and other proteins of that virus ...
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1answer
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Why does CDC's RT-PCR protocol for Covid-19 use the N gene, but the Charite one the E gene and RdRp?

The Charite protocol mentioned among other things that Of note, the N gene assay also performed well but was not subjected to intensive further validation because it was slightly less sensitive. ...
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1answer
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Clinical implications of observed faster mutation rate of SARS-CoV-2 in group quarantine?

This was posted as a rapid communication on WHO's bulletin: 28 specimens of COVID-19 patients from the cruise with a 3 week quarantine period were collected in USA and Japan from February 10 to ...
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1answer
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Could COVID-19 be less “dangerous” by the pass of the time?

Could COVID-19 be less "dangerous" by the pass of the time, say for instance, on August? By dangerous I mean, less aggressive in terms of the symptoms, mortality, less probability of caught the virus,...
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Is there a good recent review on the treatment options for COVID19?

I am looking for a summary/review of all the treatment options that have been studied for COVID19? The British medical journal is updating a tremendously helpful ressource (https://doi.org/10.1136/bmj....
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What protection does T-cell immunity confer for Covid?

This preprint, which was just released today, says that while some of the Covid-19 variants evade antibody immunity, they do not evade T-cell immunity. It says that this is true both of T-cell ...