Questions tagged [pharmaceutical]

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4
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0answers
82 views

How does metformin interact with nicotine?

Does co-use of nicotine replacement therapy and metformin increase lactic acidosis risk? If so, how?
3
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0answers
50 views

Do pharmaceuticals which increase dopamine and norepinephrine levels in the brain significantly increase histamine levels?

I imagine any medication that has an effect on catecholamines would in some way increase histamine levels as well, just for the fact that histamine is part of the 'fight or flight' response and seems ...
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38 views

How do drug companies know how to produce a generic drug?

Do the original companies have to reveal their manufacturing process to the public before they sell the drugs and the other companies can copy from them after their patent is expired?
3
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1answer
29 views

Mechanism of Metformin in Lactic Acidosis

High dosages of metformin and other biguanides are liked to lactic acidosis. What is the pharmacological mechanism behind this? I am aware the people have survived doses as high as 63 grams, but at ...
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33 views

How does donepezil impact the immune system?

Is it immunosuppressive? If so, to what extent? What are the mechanisms for this effect?
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105 views

What could be the reason for difference in adverse effects profile between original and generic Clopidogrel?

I was consulted on the following clinical case: An elderly woman (over 65 years old) on Plavix due to 2 CVAs in the last few years. Six months ago treatment was changed to a generic Clopidogrel ...
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0answers
20 views

Cancer treatment through regulation of myeloid-derived suppressor cells

There are many ongoing clinical trials that leverage the power of the immune system to recognize tumor cells such as CD47 and PDL1/PD1, and even engineered T cells! I ran across an immune cell type ...
1
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0answers
26 views

Why do most drugs target G-protein receptors?

I've read that more than 50% drugs target the g-protein coupled receptors: What is so special with them that they are the targets for such a wide range of diseases?
1
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33 views

Can marigold extract be used in mosquito repellent ointment?

I am doing research on mosquito repellent as a part of my college project. I have found various sources of marigold being used as insect repellent such as the following link- https://www.ncbi.nlm....
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0answers
33 views

Where can I find the original brand names of every psychotropic medication?

I'm looking for a place to find the original (initial) brand name of every psychotropic medication when it was first introduced (internationally, not necessarily in the US). I'm not interested in ...
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0answers
15 views

Can amphetamines suppress reactivity to scratch testing (for immunotherapy)?

My understanding's that amphetamines are immunosuppressive... Theoretically, couldn't these drugs result in false negatives?
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41 views

Immune system & methylphenidate?

How and to what extent does methylphenidate impact immune system function? How does its impact compare to that of amphetamines?
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24 views

What's The Minimum Staffing/Logistics For Running A Hospital?

Specifically, a hospital serving a local population of 200-400 people, and assuming departments include ER, ICU, dentistry, maternity, outpatient, pharmaceutical, radiology, and general surgery. What ...
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22 views

What is a PAINs (pan-assay interference compounds)? How do you prove that a compound is a PAIN? And IMPs (invalid metabolic compund)?

I've been reading about curcumin and it seems to have been pretty useful in numerous clinical trials (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535097/), although its biodisponibility is "abysmal" ...
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21 views

How long does Resalor keep before expiry?

Once a prescription for Resalor (Prucalopride) is filled, how long does it remain viable before its expiration date?
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42 views

What is the process of calculating if a molecule is helpful\harmful to an organism?

From reading about pharmacology through the years I synthesized from my own prior research that the process of calculating if a molecule is helpful to an organism and when it is also harmful is this: ...
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36 views

Why aspirin dose is reduced in gastric achlorydia?

Aspirin remains in unionised form in acidic $pH$ but this unionised form is a diffusible form which is helpful in absorption across lipid membrane. My reasoning almost tries to contradict the ...
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28 views

Sublingual Spray Protocol

I want to start learning about sublingual spray mechanisms. Where can I start with? Thanks in advance