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Questions tagged [pharmaceutical]

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17 views

Cancer treatment through regulation of myeloid-derived suppressor cells

There are many ongoing clinical trials that leverage the power of the immune system to recognize tumor cells such as CD47 and PDL1/PD1, and even engineered T cells! I ran across an immune cell type ...
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2answers
131 views

Are there beneficial compounds in cigarette smoke?

The UKPDS 50 study suggested that smokers experience lower rates of diabetic retinopathy Somewhat counter-intuitively, smoking status was inversely related to the development of new lesions and to ...
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33 views

Why aspirin dose is reduced in gastric achlorydia?

Aspirin remains in unionised form in acidic $pH$ but this unionised form is a diffusible form which is helpful in absorption across lipid membrane. My reasoning almost tries to contradict the ...
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23 views

Why do most drugs target G-protein receptors?

I've read that more than 50% drugs target the g-protein coupled receptors: What is so special with them that they are the targets for such a wide range of diseases?
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29 views

Can marigold extract be used in mosquito repellent ointment?

I am doing research on mosquito repellent as a part of my college project. I have found various sources of marigold being used as insect repellent such as the following link- https://www.ncbi.nlm....
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2answers
27 views

Term for manufactured drug

What is the English term for a manufactured pharmaceutical drug of a specific strength and dosage form, i.e. a pill, an ointment etcetera?
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1answer
91 views

Dextroamphetamine vs Dextroamphetamine Salt Combo

Important: I've already consulted my doctor and am not seeking medical advice. I'm just curious here. I've been prescribed and have taken Dextroamphetamine for some time (round orange pill). Recently ...
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32 views

Where can I find the original brand names of every psychotropic medication?

I'm looking for a place to find the original (initial) brand name of every psychotropic medication when it was first introduced (internationally, not necessarily in the US). I'm not interested in ...
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1answer
91 views

What is the benefit of effervescent tablets?

So you have these 'fizzing' tablets, that are to the best of my knowledge referred to as effervescent tablets. The wiki page provides some details, including that they are tablets which are designed ...
6
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1answer
32 views

What resources are available to identify oral medication?

What databases are available to visually identify oral medication found without packaging? Are there different databases for US, European, Far East, etc?
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30 views

Heart Rate response to beta-blockers in elderly vs adults [closed]

Beta-blockers act by decreasing the heart rate of the patient. Why is this response decreased in the elderly?
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48 views

Do pharmaceuticals which increase dopamine and norepinephrine levels in the brain significantly increase histamine levels?

I imagine any medication that has an effect on catecholamines would in some way increase histamine levels as well, just for the fact that histamine is part of the 'fight or flight' response and seems ...
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37 views

How do drug companies know how to produce a generic drug?

Do the original companies have to reveal their manufacturing process to the public before they sell the drugs and the other companies can copy from them after their patent is expired?
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1answer
29 views

Does use of NSAIDs prolong recovery time from febrile illness?

My understanding's that fever's an immune system response to pathogens. Would suppression of this response delay time to recovery?
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59 views

Acetaminophen after a heart attack [closed]

My grandmother was prescribed Dolo 325 (acetaminophen or paracetamol) after she had an episode of a silent heart attack. The dose is to be taken twice daily. Can anyone explain how this treatment ...
4
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1answer
73 views

Is Moderated Caffeine Good? (if so how much and how often)

I have never engaged in caffeine except in rare circumstance where I take Excedrin due to a headache/migraine. However, after reading about the enhanced mental state from caffeine and trying a cup of ...
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31 views

How does donepezil impact the immune system?

Is it immunosuppressive? If so, to what extent? What are the mechanisms for this effect?
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14 views

Can amphetamines suppress reactivity to scratch testing (for immunotherapy)?

My understanding's that amphetamines are immunosuppressive... Theoretically, couldn't these drugs result in false negatives?
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41 views

Immune system & methylphenidate?

How and to what extent does methylphenidate impact immune system function? How does its impact compare to that of amphetamines?
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79 views

How does metformin interact with nicotine?

Does co-use of nicotine replacement therapy and metformin increase lactic acidosis risk? If so, how?
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24 views

What's The Minimum Staffing/Logistics For Running A Hospital?

Specifically, a hospital serving a local population of 200-400 people, and assuming departments include ER, ICU, dentistry, maternity, outpatient, pharmaceutical, radiology, and general surgery. What ...
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19 views

What is a PAINs (pan-assay interference compounds)? How do you prove that a compound is a PAIN? And IMPs (invalid metabolic compund)?

I've been reading about curcumin and it seems to have been pretty useful in numerous clinical trials (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535097/), although its biodisponibility is "abysmal" ...
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1answer
154 views

How can I bypass the most expensive drug in the world which goes on sale and get cured? [closed]

I have an ALS-like disease called SMA type III. It's a progressive neurodegenerative disease and there was no cure until recently. I have been waiting for a cure for forty years. Thanks to ...
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28 views

Sublingual Spray Protocol

I want to start learning about sublingual spray mechanisms. Where can I start with? Thanks in advance
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103 views

What could be the reason for difference in adverse effects profile between original and generic Clopidogrel?

I was consulted on the following clinical case: An elderly woman (over 65 years old) on Plavix due to 2 CVAs in the last few years. Six months ago treatment was changed to a generic Clopidogrel ...
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25 views

Mechanism of Metformin in Lactic Acidosis

High dosages of metformin and other biguanides are liked to lactic acidosis. What is the pharmacological mechanism behind this? I am aware the people have survived doses as high as 63 grams, but at ...
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1answer
399 views

Which suitable eye drop to choose for computer vision syndrome? [closed]

Working and chilling using PC over 10h a day, which results in a very uncomfortable eye condition. My eyes are often quite red and I feel "sandpaper" in the eyes. I see a very big variety of eyedrops -...
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21 views

How long does Resalor keep before expiry?

Once a prescription for Resalor (Prucalopride) is filled, how long does it remain viable before its expiration date?
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2answers
2k views

Has something changed making it harder to get 90 day supplies of routine meds?

When a doctor writes a prescription for 1 per day with a quantity of 30 with 2 refills, I have never heard of anyone having a problem getting 90 days of the medication at once. That's 30 days for the ...