Questions tagged [medications]

Questions related to intake, use, safety, side effects, pharmacokinetics, pharmacodynamics, drugs, prodrugs and medication.

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2answers
227 views

Activated charcoal administered rectally?

A colleague of mine, an experienced pharmacist, told me that there used to be a product of activated charcoal called Charcodote, which could have been used either orally or rectally. I doubted this, ...
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0answers
30 views

Why do antidepressant drugs increase body mass?

Serotonin is an anorexient neurotransmitter. But if I am right, antidepressant drugs like SSRIs increase the amount of serotonin in the brain. So why do antidepressants increase body mass if ...
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0answers
19 views

How do you know if an over the counter drug is safely processed and safe to use?

How do you know if an over the counter drug is safely processed and safe to use? I have not heard of the brand SDA Laboratories before, so tried searching online to see if it has any safety ...
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0answers
24 views

Is metamizole associated with rebound headaches?

I can't find any specific mention on the internet if Metamizole (most known as dipyrone) is specifically associated with rebound headaches like other pain relieve medications like Aspirin, ...
2
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1answer
60 views

If placebo controls work even when the patient is aware that the treatment is a placebo. Why are deceptive placebo controls used?

Placebos are “fake” treatments prescribed for the psychological benefit to the patient rather than for any physiological effect. Placebos are used for conditions defined by “self-observation” symptoms ...
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0answers
22 views

Tick bite treatment. Doxycycline intake suspended after 3 days only. If substituted by Bactrim, is there a risk to develop bacteria resistant?

A patient was bitten by a tick and carried the tick on his skin for 5/6 days (which got engorged at the end). Then the tick dropped spontaneously. He has been prescribed a preventive antibiotic course ...
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1answer
49 views

Why are some medicines recommended to be taken with a high dose and low frequency?

Alendronate sodium is an osteoporosis medicine commonly recommended as a once-a-week 70 mg dose. Why not 35 mg twice a week? or 10 mg daily? I am guessing that a more steady intake like this would be ...
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2answers
44 views

Book of drug interactions

Where can I find full list of drug _ drug interaction & adverse reaction, apart from pdr.net, I mean to say in a book form. What books of medical science contain these information? Please name a ...
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1answer
43 views

interaction between Mirtazapine & Mesalamine & olanzapine [closed]

Is there any adverse reaction or interaction between Mirtazapine & Mesalamine & olanzapine, If taken in low doses(mirtazapine 7.5 & Olanzapine 2.5).
3
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1answer
50 views

Why is methadone not prescribed with naloxone for opioid use disorder?

Two possible treatments for opioid use disorder are methadone or buprenorphine/naloxone (suboxone). According to the National Alliance of Mental Illness(https://www.nami.org/About-Mental-Illness/...
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24 views

To generate induced-plutipotent stem cells you can use the Yamanaka factors or use pharmaceuticals, which is better and why?

To make this question more open, it doesn't have to be specifically the Yamanaka factors (It could be fewer than the 4, or other factors). E. g. Epigenetic eraser pharmaceuticals https://www.nature....
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0answers
23 views

Where can I find a list (even if only partial) of excipients that cause a medication to be indivisible?

Certain tablet formulations should not be divided or halved because the tablets are film-coated for low pH resistance (i.e. for safe passage in the stomach) or because the active ingredient is not ...
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1answer
52 views

Are antibiotics the only class of drugs whose effectiveness reduces over time?

The phenomenon of antibiotic resistance is well known: an antibiotic is effective when first introduced to the market, but over the years, its effectiveness decreases as resistant strains of bacteria ...
3
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1answer
57 views

Why do corticosteroids have few kidney-related side effects?

Prostaglandins are involved with promoting various renal functions. Therefore, NSAIDs, like indomethacin which inhibits protaglandin formation through COX enzyme inhibition, tend to have many side-...
3
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1answer
53 views

Why is prothrombin time used to monitor warfarin and not aPTT?

Warfarin is said to change prothrombin time (PT) but not activated partial thromboplastin time (aPTT) (for practical purposes at least anyways, not really sure). But looking at the mechanism of action ...
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1answer
47 views

Is it useless to drip Vitamin D drops on your tongue? [closed]

One celebrity doctor in my country says that Vitamin D can be absorbed only in the small intestine and that dropping Vitamin D drops on your tongue is therefore useless, because most of the liquid ...
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0answers
23 views

Have any conclusions been made regarding the interaction of Covid-19 and ACE inhibitor medications? [duplicate]

About two months ago, I started to see articles appear regarding the potential interactions between ACE inhibitor medications (commonly used to treat high blood pressure) and the severity of Covid-19 ...
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0answers
46 views

What exactly is the meaning of “No doping” sign on a drug package?

I noticed a "No doping" sign on the back of a pack of Dopamine HCl ampoules. It looks like this: I was wondering what is the purpose of this sign. I am guessing that it means that the drug should not ...
1
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1answer
31 views

Prevent-Release Systems for Opioid Painkillers Vs Placebo

today we were studying oral novel drug delivery systems. The class was prerecorded (due to pandemic) There was this table in the slides "strategies and benefits of modifying drug release table" and I ...
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1answer
55 views

Does Ivermectin treat COVID-19 coronavirus infection?

Does the anti-parasitic Ivermectin work in actual human studies versus the Petri dish in vitro studies, when treating coronavirus COVID-19 infection? And if so, is it safe in humans? An in vitro ...
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1answer
70 views

What is the difference between Dry cough, Wet cough, Chesty Cough, Barking cough?

I am doing some research on cough sounds but my background is not health sector and I am facing issues to identify the correct type of cough. I have two doubts : Is chesty cough Wet cough? Is ...
7
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1answer
233 views

How is Lopinavir + Ritonavir expected to stop COVID-19?

There are four drugs being tested for effectiveness against COVID-19 in the SOLIDARITY trial. Three of them have obvious potential mechanisms of action: Remdesivir is an RNA polymerase inhibitor. ...
2
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1answer
54 views

Why are multiple courses of isotretinoin necessary to treat acne?

The following guidances don't detail why multiple courses are more efficacious? Aug 21 2019 PRODUCT MONOGRAPH on Accutane, Hoffmann-La Roche Limited, p. 13 of 36. Effects of multiple courses of ...
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2answers
104 views

What are the special medications to treat Covid-19?

We know there is no cure for Covid-19 (currently) and the treatment focuses on managing symptoms as the virus runs its course. The main symptoms of Covid-19 are -Fever -Cough -Shortness of breath ...
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19 views

Study type/design used in an coronavirus article?

I came across an article given here While I was reading the article, I wasn't able to find the study type/ design? Can you please help me find out what is the study design/type here? Meaning we ...
2
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1answer
70 views

ACE2 Inhibition as therapeutic candidate?

Disclaimer: I am a scientist, but this is not my main field so sorry if I've not used the correct terminology at this busy time... Since the coronavirus protein bonds with and gains entry to the cell ...
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3answers
111 views

Are there any central trackers for COVID-19 trials?

There are several aggregate central trackers for the spread of COVID-19. Like this one, for example. Is there anything similar for trials? Or trials in the pipeline? Either vaccines or treatments?
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2answers
92 views

Can oseltamivir shorten the duration of COVID-19 and inhibit replication and transmission of the SARS-CoV-2 (2019-nCoV) virus?

Oseltamivir (Tamiflu) is an antiviral medication used to treat and prevent influenza A and influenza B (flu). It is said to reduce symptom duration even when initiated more than 2 days after symptom ...
2
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1answer
21 views

How do huge computer simulations help in medical research?

I found the there is a project Folding@home to fight against COVID-19. As far as I understand, it uses huge amount of computing power to find a cure. Why do we need such a huge number of potential ...
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22 views

Tilt table test and beta blockers

Is tilt table test indicative with beta blockers for dysautonomia diagnosis? Or is it require drug withdrawal?
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1answer
40 views

Side-effects or other medical conditions for diabetic patients

I have a database of diabetic patients and their medication/lab test data as well. 1) I am planning to run a simple analysis like finding out incidence rate example: amongst the T2DM patients that I ...
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2answers
55 views

T2DM medication treatment pathway

I am looking at the T2DM medications specified here and have a few questions about them. 1) Why don't I see drugs like Troglitazone, Tolazamide, Acarbose, Acetohexamide, Chlorpropramide, Miglitol? ...
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1answer
36 views

Rationale for Pilocarpine instillation after retrobulbar haemorrhage

BACKGROUND: Retrobulbar haemorrhage may occur due to retrobulbar block. Immediate pressure bandage after instilling one drop of 2% pilocarpine and postpone of operation for a week is advised. What is ...
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0answers
26 views

T2DM diagnosis vs disorder due to T2DM diagnosis?

I have a database of diabetic patients. Mostly 80 % are T2DM patients. Now I would like to identify the T2DM patients based on their conditions reported. I mean when patients visit hospital (diabetic ...
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1answer
36 views

How to interpret diabetic complications?

I have a database of diabetic patients. Mostly 80 % are T2DM patients. Now I would like to identify the T2DM patients based on their conditions reported. I mean when patients visit hospital (diabetic ...
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0answers
35 views

Is there a greater benefit as as to why an ob-gyn will prescribe a birth control with higher risk of Venous Thromboembolism?

It is already known that combined oral contraceptive (COCs) pills increase the risk of serious complications such as Venous Thromboembolism. However there are other options that have relatively much ...
3
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1answer
73 views

General purpose vomit response control?

Is there a general purpose antiemetic for vomit response control? Many vomit control solutions are focused on specific causes for the vomiting. Some common causes of nausea/vomiting: Cancer ...
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0answers
52 views

What is the process of calculating if a molecule is helpful and/or harmful to an organism?

From reading about pharmacology through the years I synthesized from my own prior research that What is the process of calculating if a molecule is helpful and/or harmful to an organism is this: A ...
2
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1answer
36 views

How does Diabetic specialist clinic work?

I am from IT domain and would like to seek some help on certain medicine related questions I would like to know how does Diabetic specialist hospital/clinic work for Diabetic patients when compared ...
3
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1answer
44 views

What is daily sedation interruption for ventilated patients?

I was reading about ventilator bundle here and came across this term called Daily Sedation Interruption. Does this term mean break in giving the sedation drugs? How can this help in reducing the ...
2
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1answer
58 views

T2DM Fasting glucose level - extreme cases

I am working on clinical data analysis and currently dealing with T2DM patients. When I look at their Fasting glucose level readings, I see that their values range from 0.9 mmol\L to 64 mmol\L The ...
2
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1answer
43 views

Do patients with VAE stay in ICU for longer time?

I was reading online that people when put in ICU under mechanical ventilation, can develop Ventilated Associated Events. What I would like to know is: does the stay in ICU increase for people who ...
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1answer
68 views

Fluid balance range for human

I am working on clinical data analysis with patients from icu who are mechanically ventilated and in ICU for 4 or more days. Currently I tried to calculate their fluid balance based on the input and ...
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0answers
54 views

What are the main problems with non-injectable ways to administer molecules into the human body?

From past reading in various sources there seems to me to be many ways to administer molecules into the human body without injections that cause tissue trauma but that these ways generally aren't ...
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0answers
29 views

Why is Toradol no longer available in the US?

A few years ago I was given Toradol for kidney stone pain. It was magical. My friend just had a kidney stone and was given morphine, then Dilaudid. Curious about the differences, I went googling, only ...
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1answer
33 views

Drug dosage in pharmacology [closed]

Please give a overview about how the dosage of a particular drug (e.g. ciprofloxacin) is determined in pharmacology?
3
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1answer
64 views

Why did it take so long to notice that Zantac had carcinogenic ingredients?

Why did it take so long to notice that Zantac had carcinogenic ingredients? Sanofi is recalling the popular heartburn drug Zantac. The generic name for the drug is Ranitidine. Apparently, the ...
1
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1answer
120 views

Why many usually-very-painful medical processes aren't done under conscious, generally painless-painkilling?

Many usually-very-painful medical or medical-defined processes such as: Hair transplant Lip botox Fecal impaction removal Dental cleaning (stone removal) Aren't being done under conscious, generally ...
4
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0answers
35 views

Why/how are some drugs nephrotoxic?

I want to know the (more or less) exact mechanism by which specific nephrotoxic medications damage the kidneys. For some drugs it seems relatively intuitive that they interfere with the function of ...
3
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1answer
2k views

Is there an interaction between methamphetamine and dental anesthetic?

According to the sign shown in this post on Reddit, using methamphetamine and dental anesthetic together is lethal. If you use Methamphetamines (Crystal Meth, Crank, Speed, Glass, Tweak, Yaba)...

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