Questions tagged [medications]

Questions related to intake, use, safety, side effects, pharmacokinetics, pharmacodynamics, drugs, prodrugs and medication.

Filter by
Sorted by
Tagged with
0 votes
0 answers
11 views

Why do many steroid dose packs have ramp up dose but no taper off?

I am just wondering why many steroid dose packs (such as a medrol dose pack) have patients slowly increasing the dose but don't taper off after the maximum dose is achieved. Would this not cause (at ...
2 votes
0 answers
67 views

Are there medications that treat premature ejaculation without interfering in serotonin levels?

The widespread medications that are being used to treat premature ejaculation (PE) are kind of antidepressants called SSRIs (Selective Serotonin Reuptake Inhibitors). But the problem with this kind of ...
3 votes
1 answer
48 views

Analgesics are drugs which relieve pain. Are there other drugs which do the opposite -- make you more sensitive to pain?

I am curious. Are there durgs which do the opposite of analgesics? That is, make you more sensitive to pain, but don't cause pain themselves? If so, what is this class of drugs called? What is the ...
1 vote
0 answers
10 views

IPSD, IISD, MPP1+ and MSI scores [closed]

First of all, sorry if this is not the correct Stack. I am translating a clinical protocol for an antibody that could be used against certain types of cancer. I found the following and I have no idea ...
  • 11
5 votes
1 answer
72 views

Why do calcium channel blockers have an adverse effect of edema but Beta Blockers do not cause edema as a side effect?

My pharmacology professor glossed over the mechanism that causes edema besides briefly discussing after/preload. If Calcium channel blockers and beta blockers both are negative ionotropes then why isn'...
1 vote
1 answer
97 views

Why is there HBr in dextromethorphan HBr?

I was reading off the back label of a Nyquil bottle and I realized instead of dextromethorphan, it said dextromethorphan HBr. I also realized that instead of phenylephrine, it said phenylephrine HCl. ...
0 votes
0 answers
23 views

HPA axis recovery

How long does it take for the HPA axis to recover after prolonged (<2 weeks therapy ) steroid therapy apart from other side effects?
0 votes
0 answers
26 views

Information regarding SSRIs

How long can one continue to take SSRIs for? (Exp. Sertraline) Is there any database where I can find information about safe duration of therapy for drugs?
4 votes
0 answers
55 views

Do topical anti-inflamatory preparations work topically?

There are topical anti-inflamatory preparations where the advertising at least implies that they work topically, in that the effect will be more localised by the use of a topical preparation than if ...
  • 478
0 votes
0 answers
66 views

Could some common allergies be treated medicinally without antihistamins/steroids/epinephrine and if so how?

A common allergy such as house dust-mite allergy or a food allergy can be treated with antihistamines, steroids and epinephrine. I understand that there are Mast cell stabilizers and Anti-leuko-...
  • 5
-4 votes
1 answer
91 views

Lack of studies on small doses of chlorine dioxide as treatment for diseases

While ingesting high doses of chlorine dioxide are toxic to humans, this is not the case for smaller doses. Ingesting, for example, 30 mg per day for a few days would probably not result in serious ...
  • 93
0 votes
0 answers
34 views

How do blood substitute increase the risk of stroke?

When describing blood substitute's (BS's) made of perfluorocarbons use in clinical trials, one of the most commonly described side effected in the increase risk of stroke in the area were the PFC is ...
user avatar
0 votes
0 answers
33 views

Definition of fasted state

Is there a general definition what consists a fasted state? The medical literature I have read so far uses the term ambiguously, i.e. from overnight abstinence to 2h of no food intake. Is there a ...
  • 101
1 vote
1 answer
41 views

Is generic name a synonym for active ingredient?

What is the difference between active ingredient and generic name? Is generic name always equal to the active ingredients or are these sometimes different? For example, Benadryl has a generic name, ...
  • 111
0 votes
0 answers
38 views

Using Aspirin to Counter Platelet Aggregating Effects of COX2 Inhibitors?

I've been reading pharmacology of NSAIDs a bit and I came over the point that, Selective COX2 Inhibitors will cause unopposed Thromboxane A2 action but are otherwise great as anti-inflammatory agents. ...
  • 61
0 votes
0 answers
34 views

Why have we obtained significantly different results for moisture content on two different brands of moisture analyzers?

Our pharmaceutical laboratory has two moisture analyzers in use; one is Shimadzu MOC3u (MC-A), and the other is Mettler-Toledo HC103 (MC-B). A sample from the same batch was put on each instrument to ...
  • 9
1 vote
0 answers
38 views

How to estimate equivalent doses of similar medicines with different route of administration?

I am trying to compare the two medications used as rescue medications for seizures 5mg Rectal Diazepam 2.5mg Buccal Midazolam (Buccolam) I am aware that Midazolam is considered to be more potent than ...
  • 111
4 votes
1 answer
102 views

Would slight shifting of administration times of Paxlovid impact its efficacy?

Paxlovid (nirmatrelvir/ritonavir) is an oral medication indicated for patients recently diagnosed with COVID-19 and who are at high risk of deterioration. This drug received an emergency use ...
  • 1,608
2 votes
1 answer
89 views

Why do so many OTC drugs have one-size-fits-all dosing instructions?

Every over-the-counter medication I've seen in recent memory (in the USA) has had instructions along the lines of, "Adults and children 12 years and older: 1 pill every 4 hours, 12 and under: ...
2 votes
0 answers
56 views

Does a Doctor exist that is able to encapsulate triaging differing specialities? [closed]

My girlfriend has multiple health issues: ASD ADHD BPD Type 1 Diabetes Wolf Parkinsons Disease Non-alcoholic fatty liver disease fibromyalgia Perferatted Valve Reynauds Disease The issue is each one ...
-4 votes
1 answer
183 views

Has there been any medical studies as to whether drinking a 'Hot Toddy' can help to ward off or to help heal someone who has COVID-19? [closed]

I am curious to know if there has been any medical studies that have been conducted to ascertain if drinking a 'Hot Toddy' every day will decrease the odds of someone being infected by the COVID-19 ...
0 votes
0 answers
25 views

What are the basic reasons for normogonadotropic hypogonadism?

I'm can't fine the full known scope of reasons of male normogonadotropic hypogonadism. From this article I see the two basic reasons: Gonadal dysgenesis variants (residually functioning ovarian ...
  • 101
8 votes
1 answer
92 views

Why are Drugs.com side-effect incidence rates so different from manufacturer/FDA reports?

Entries at Drugs.com have a section on "Side Effects... For Healthcare Professionals" which present percentages for incidence rates of side effects. However, I've found that the rates ...
5 votes
2 answers
573 views

Ritalin/Concerta/Methylphenidate is an amphetamine?

FIDE (the governing body of international chess competition) says here: The most relevant banned substances for chess are: • Amphetamines – e.g. Adderall, Ritalin (...) Image: I think either ...
  • 445
0 votes
1 answer
57 views

H1-antihistamines classified according to pharmacology?

I've been researching H1-antihistamines for personal reasons. And I'm trying to find out if H1-antihistamines are sorted based on pharmacology. I understand that H1-antihistamines have up to three ...
0 votes
0 answers
20 views

Amino acid data - 101 for beginners

I am a data analyst who received amino acid data from lab to transform them into a form suitable for analysis. What I would like to check with you is check whether the below terms mean the same? For ...
  • 299
-4 votes
1 answer
87 views

How do I stop my doctor from killing me? [closed]

In the international best-selling author, Dr Vernon Coleman's book 'how to stop your doctor killing you', he explains that the person most likely to kill you is not a burglar, a mugger, a deranged ...
  • 1
1 vote
0 answers
48 views

What is the state of transmissible vaccines?

I was thinking about viral gain of function research -- and firebugs playing with matches -- when it hit me: if a highly contagious, but harmless version were engineered it could outcompete more ...
0 votes
1 answer
118 views

Why are some tablets Telmisartan, Amlodipine and Hydrochlorothiazide bilayered and some are not?

I recently saw that some brands of Telmisartan, Amlodipine and Hydrochlorothiazide tablets are bilayered and some are not? On Googling I found this Bilayered tablet technology separates two ...
user avatar
0 votes
1 answer
68 views

How effective is sinovac/sinopharm vaccine

it's time for me to get vaccinated with sinovac vaccine. I am actually a little bit nervous, about its effectiveness, I am not a docotor and I have no idea what's behind it. I am worrying that it ...
0 votes
1 answer
65 views

Decreasing Risks of MAOIs

Are Monoamine oxidase inhibitors (MAOIs) as dangerous as they are made out to be? I am new to pharmacology, but here is my understanding of MAOIs and antidepressants in general: There is a ...
user avatar
3 votes
1 answer
75 views

Monotherapy of multiple drugs or combination therapy - Beginner 101

Let's say that patient A is taking drugs like as shown below |---atenolol-----esmolol----nebivolol---------------------| |---s------e-----s-----e----s-------e---------------------| here s and e ...
  • 299
1 vote
0 answers
37 views

Does Remdesivir really go bad after reconstitution with sterile water?

I was recently looking at how long can Remdesivir be stored in its different forms. I came up across several articles provided by the FDA and Gilead Sciences and others. What caught my eye was the ...
  • 111
1 vote
1 answer
28 views

How can an individual seek to get an idea investigated as a potential treatment, or seek a change in a particular guideline?

It would be dangerous for the general public to provide advice on 'what they reckon' would be a good treatment or a good guideline for medical advice; and that has clearly caused problems in the past. ...
  • 109
0 votes
1 answer
49 views

Is there a free vaccine or medicinal product database?

Is there a database that allows me to query for available vaccine products by ingredients? For instance, I want to find an available vaccine product that contains "Streptococcus pneumoniae ...
0 votes
0 answers
30 views

What is the average optimal time interval before or after a meal when medicines should be taken?

Many medicines and supplements specify that they should be taken either before of after a meal—and I know that this means some time must pass, not gulping the med immediately next to the meal. However,...
  • 101
1 vote
0 answers
19 views

Effects of anti-Rh(D) antibodies on the fetus

Rh disease is caused by the irruption in the fetal circulation of anti-Rh(D) antibodies. This only happens when there has been a prior exposure of the mother to Rh+ RBC. To prevent Rh sensitization ...
2 votes
1 answer
64 views

Are there any randomized clinical trials being conducted on TMPRSS2 inhibitors for Covid-19 treatment?

In a recent paper on why hydroxychloroquine doesn't really work against Covid-19, it's been demonstrated that SARS-CoV-2 is much better at taking advantage of TMPRSS2 at the cell membrane surface, so ...
  • 5,883
0 votes
1 answer
34 views

How to evaluate long-term safety of biological interventions?

I'm wondering how to go about evaluating the long term effects of a biological intervention, like a new therapeutic. There is emergent evidence that common medications like NSAIDs or anticholinergics ...
7 votes
1 answer
188 views

How do mRNA vaccines work and what are their advantages over traditional vaccines?

How do mRNA vaccines work? To my intuitive understanding, for an mRNA vaccine to work, the mRNAs injected into the patient need to first enter a cell and get translated into proteins. Those proteins ...
  • 485
1 vote
1 answer
187 views

Does L-theanine increase caffeine's half-life?

Does consuming L-theanine with caffeine, either in drink (like matcha) or in pill form, affect the half-life of caffeine? All I can find about these substances ares claims that L-theanine slows the ...
2 votes
1 answer
72 views

Can an individual survive methanol poisoning if the drink is mixed with isopropanol? [closed]

I have a friend who last year suffered severe drug addiction and decided to consume windshield washer fluid that contains methanol/isopropanol. He drank it from Saturday to Wednseday before being ...
4 votes
1 answer
114 views

Is there a relationship between slope of the plasma concentration-time curve and addictiveness?

I've been reading about addiction medicine, and a lot of the discussion on pharmacokinetics seems to imply a truth that is never actually stated in words. Background: The Plasma Concentration vs. Time ...
-1 votes
1 answer
94 views

Is calling dexamethasone a "psychoactive steroid medication" correct use of the term psychoactive? Because it has reported psychological side effects?

Pete Buttigieg has a decent educational and professional background and good command of the English language and some appreciation for facts, which is why I call this choice of words into question and ...
  • 209
3 votes
2 answers
1k views

Activated charcoal administered rectally?

A colleague of mine, an experienced pharmacist, told me that there used to be a product of activated charcoal called Charcodote, which could have been used either orally or rectally. I doubted this, ...
  • 1,608
2 votes
0 answers
41 views

Why do antidepressant drugs increase body mass?

Serotonin is an anorexient neurotransmitter. But if I am right, antidepressant drugs like SSRIs increase the amount of serotonin in the brain. So why do antidepressants increase body mass if ...
2 votes
1 answer
71 views

How do you know if an over the counter drug is safely processed and safe to use?

How do you know if an over the counter drug is safely processed and safe to use? I have not heard of the brand SDA Laboratories before, so tried searching online to see if it has any safety ...
  • 121
0 votes
0 answers
45 views

Is metamizole associated with rebound headaches?

I can't find any specific mention on the internet if Metamizole (most known as dipyrone) is specifically associated with rebound headaches like other pain relieve medications like Aspirin, ...
  • 789
3 votes
1 answer
91 views

If placebo controls work even when the patient is aware that the treatment is a placebo. Why are deceptive placebo controls used?

Placebos are “fake” treatments prescribed for the psychological benefit to the patient rather than for any physiological effect. Placebos are used for conditions defined by “self-observation” symptoms ...
  • 372
1 vote
0 answers
30 views

Tick bite treatment. Doxycycline intake suspended after 3 days only. If substituted by Bactrim, is there a risk to develop bacteria resistant?

A patient was bitten by a tick and carried the tick on his skin for 5/6 days (which got engorged at the end). Then the tick dropped spontaneously. He has been prescribed a preventive antibiotic course ...

1
2 3 4 5
9