Questions tagged [medications]
Questions related to intake, use, safety, side effects, pharmacokinetics, pharmacodynamics, drugs, prodrugs and medication.
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Are treatments for (hyper/hypo)parathyroidism mutually exclusive from treatmeants to (hyper/hypo)calcemia?
Summarized in the table below the drugs that were listed in my professor's lecture slides for the treatment of Hyperparathyroidism (first column) and hypoparathyroidism (second column)
Are treatments ...
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Why would it be necessary to take a brand name medication if a generic drug is available?
Many prescription pads have a way for the doctor to indicate if a brand name medication must be dispensed instead of the generic version (e.g. a line where they can write something like "brand ...
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Why can't Asian flush be treated in a similar way to lactose intolerance?
I have been reading about the Asian flush, which is caused by a histamine reaction to a toxic byproduct of alcohol metabolism, acetaldehyde.
Some individuals are able to suppress the histamine ...
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Why do many steroid dose packs have ramp up dose but no taper off?
I am just wondering why many steroid dose packs (such as a medrol dose pack) have patients slowly increasing the dose but don't taper off after the maximum dose is achieved. Would this not cause (at ...
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Are there medications that treat premature ejaculation without interfering in serotonin levels?
The widespread medications that are being used to treat premature ejaculation (PE) are kind of antidepressants called SSRIs (Selective Serotonin Reuptake Inhibitors). But the problem with this kind of ...
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Analgesics are drugs which relieve pain. Are there other drugs which do the opposite -- make you more sensitive to pain?
I am curious. Are there durgs which do the opposite of analgesics? That is, make you more sensitive to pain, but don't cause pain themselves? If so, what is this class of drugs called? What is the ...
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IPSD, IISD, MPP1+ and MSI scores [closed]
First of all, sorry if this is not the correct Stack.
I am translating a clinical protocol for an antibody that could be used against certain types of cancer. I found the following and I have no idea ...
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Why is there HBr in dextromethorphan HBr?
I was reading off the back label of a Nyquil bottle and I realized instead of dextromethorphan, it said dextromethorphan HBr.
I also realized that instead of phenylephrine, it said phenylephrine HCl.
...
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Why do calcium channel blockers have an adverse effect of edema but Beta Blockers do not cause edema as a side effect?
My pharmacology professor glossed over the mechanism that causes edema besides briefly discussing after/preload. If Calcium channel blockers and beta blockers both are negative ionotropes then why isn'...
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Why does anybody still prescribe Citalopram with Escitalopram available (apart from price)?
As far as I could find Escitalopram is superior in every way, except for the US price (which might no longer even be the case). So why is the former still widely used worldwide? Did I miss anything?
...
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HPA axis recovery
How long does it take for the HPA axis to recover after prolonged (<2 weeks therapy ) steroid therapy apart from other side effects?
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Information regarding SSRIs
How long can one continue to take SSRIs for? (Exp. Sertraline) Is there any database where I can find information about safe duration of therapy for drugs?
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56
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Do topical anti-inflamatory preparations work topically?
There are topical anti-inflamatory preparations where the advertising at least implies that they work topically, in that the effect will be more localised by the use of a topical preparation than if ...
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In what order should ointment and lotion be applied?
I apply both moisturizing cream and a medicinal ointment/lotion on some recovering injuries. The skin is unbroken, and the medicinal lotion is primarily for the entry point of a titanium rod in my ...
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Newer drugs useful for acute heart failure
Diuretics (drugs which increase urine output), morphine and oxygen are often used to treat patients who have to come to emergency ward with acute heart failure. But what are newer drugs useful for ...
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Lack of studies on small doses of chlorine dioxide as treatment for diseases
While ingesting high doses of chlorine dioxide are toxic to humans, this is not the case for smaller doses. Ingesting, for example, 30 mg per day for a few days would probably not result in serious ...
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Could some common allergies be treated medicinally without antihistamins/steroids/epinephrine and if so how?
A common allergy such as house dust-mite allergy or a food allergy can be treated with antihistamines, steroids and epinephrine.
I understand that there are Mast cell stabilizers and Anti-leuko-...
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Are generics tested for side effects?
I have been reading about generics vs brand-name drugs. I've learned that generics go through extensive testing for bioequivalence (both rate of absorption and total absorption of the active ...
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How do blood substitute increase the risk of stroke?
When describing blood substitute's (BS's) made of perfluorocarbons use in clinical trials, one of the most commonly described side effected in the increase risk of stroke in the area were the PFC is ...
C-Consciousness
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Definition of fasted state
Is there a general definition what consists a fasted state? The medical literature I have read so far uses the term ambiguously, i.e. from overnight abstinence to 2h of no food intake. Is there a ...
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Is generic name a synonym for active ingredient?
What is the difference between active ingredient and generic name? Is generic name always equal to the active ingredients or are these sometimes different?
For example, Benadryl has a generic name, ...
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What can the variability of strength be between different brands of supposedly identical medications?
I remember reading that medications are within allowable specs if they contain +/- 30% of the labelled strength. I can't find the source of that information in order to check its validity.
If that is ...
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Why have we obtained significantly different results for moisture content on two different brands of moisture analyzers?
Our pharmaceutical laboratory has two moisture analyzers in use; one is Shimadzu MOC3u (MC-A), and the other is Mettler-Toledo HC103 (MC-B).
A sample from the same batch was put on each instrument to ...
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How to estimate equivalent doses of similar medicines with different route of administration?
I am trying to compare the two medications used as rescue medications for seizures
5mg Rectal Diazepam
2.5mg Buccal Midazolam (Buccolam)
I am aware that Midazolam is considered to be more potent than ...
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Where can I find a list (even if only partial) of excipients that cause a medication to be indivisible?
Certain tablet formulations should not be divided or halved because the tablets are film-coated for low pH resistance (i.e. for safe passage in the stomach) or because the active ingredient is not ...
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Would slight shifting of administration times of Paxlovid impact its efficacy?
Paxlovid (nirmatrelvir/ritonavir) is an oral medication indicated for patients recently diagnosed with COVID-19 and who are at high risk of deterioration. This drug received an emergency use ...
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How can I learn to swallow pills without gagging?
Many people have difficulty swallowing pills or even find themselves unable to do so. While some medications are available in other forms, many are not.
Is it possible to learn how to swallow pills? ...
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To what extent does filling more prescriptions increase the number of medication errors?
https://www.usatoday.com/story/news/nation-now/2017/05/10/skin-melts-off-medication-error/315930001/ (mirror) says:
According to the Food and Drug Administration, medication errors jumped from 16,...
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Monotherapy of multiple drugs or combination therapy - Beginner 101
Let's say that patient A is taking drugs like as shown below
|---atenolol-----esmolol----nebivolol---------------------|
|---s------e-----s-----e----s-------e---------------------|
here s and e ...
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Are there any randomized clinical trials being conducted on TMPRSS2 inhibitors for Covid-19 treatment?
In a recent paper on why hydroxychloroquine doesn't really work against Covid-19, it's been demonstrated that SARS-CoV-2 is much better at taking advantage of TMPRSS2 at the cell membrane surface, so ...
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Why do so many OTC drugs have one-size-fits-all dosing instructions?
Every over-the-counter medication I've seen in recent memory (in the USA) has had instructions along the lines of, "Adults and children 12 years and older: 1 pill every 4 hours, 12 and under: ...
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Does a Doctor exist that is able to encapsulate triaging differing specialities? [closed]
My girlfriend has multiple health issues:
ASD
ADHD
BPD
Type 1 Diabetes
Wolf Parkinsons Disease
Non-alcoholic fatty liver disease
fibromyalgia
Perferatted Valve
Reynauds Disease
The issue is each one ...
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Has there been any medical studies as to whether drinking a 'Hot Toddy' can help to ward off or to help heal someone who has COVID-19? [closed]
I am curious to know if there has been any medical studies that have been conducted to ascertain if drinking a 'Hot Toddy' every day will decrease the odds of someone being infected by the COVID-19 ...
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Why are Drugs.com side-effect incidence rates so different from manufacturer/FDA reports?
Entries at Drugs.com have a section on "Side Effects... For Healthcare Professionals" which present percentages for incidence rates of side effects. However, I've found that the rates ...
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H1-antihistamines classified according to pharmacology?
I've been researching H1-antihistamines for personal reasons. And I'm trying to find out if H1-antihistamines are sorted based on pharmacology.
I understand that H1-antihistamines have up to three ...
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Ritalin/Concerta/Methylphenidate is an amphetamine?
FIDE (the governing body of international chess competition) says here:
The most relevant banned substances for chess are:
• Amphetamines – e.g. Adderall, Ritalin
(...)
Image:
I think either ...
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What are the basic reasons for normogonadotropic hypogonadism?
I'm can't fine the full known scope of reasons of male normogonadotropic hypogonadism.
From this article I see the two basic reasons:
Gonadal dysgenesis variants (residually functioning ovarian ...
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Antidepressant response post MAOI tachyphylaxis
In 'Listening to Prozac' (Pg. 305) Kramer notes that once monoamine oxidase inhibitors (MAOIs) poop-out, depressed patients are often unresponsive to subsequent pharmacological interventions (and in ...
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How could Lyrica (pregabalin) cause hallucinations?
I've heard of this happening on rare occasion, but I cannot figure out a sensible mechanism.
I have some limited understanding of neurology and the function of GABA, and I know that ethanol (a GABA ...
CommunityBot
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Why is Lamisil Once (terbinafine film-forming solution) marketed for athlete's foot, but not for jock itch or ringworm?
Lamisil Once (terbinafine film-forming solution) is an over-the-counter antifungal medication. It's sold only in certain countries, such as Britain and Australia. You apply it once. It starts working ...
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Is there an interaction between methamphetamine and dental anesthetic?
According to the sign shown in this post on Reddit, using methamphetamine and dental anesthetic together is lethal.
If you use Methamphetamines (Crystal Meth, Crank, Speed, Glass, Tweak, Yaba)...
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How many years is considered long term drug/medication usage
Patients tend to worry about the side effects that may be caused by longterm drug/meds usage. How many years do you have to consume the drug/meds to say that you are longterm on it? Likewise, if you ...
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Amino acid data - 101 for beginners
I am a data analyst who received amino acid data from lab to transform them into a form suitable for analysis.
What I would like to check with you is check whether the below terms mean the same?
For ...
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How do I stop my doctor from killing me? [closed]
In the international best-selling author, Dr Vernon Coleman's book 'how to stop your doctor killing you', he explains that the person most likely to kill you is not a burglar, a mugger, a deranged ...
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What is the state of transmissible vaccines?
I was thinking about viral gain of function research -- and firebugs playing with matches -- when it hit me: if a highly contagious, but harmless version were engineered it could outcompete more ...
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Why are some tablets Telmisartan, Amlodipine and Hydrochlorothiazide bilayered and some are not?
I recently saw that some brands of Telmisartan, Amlodipine and Hydrochlorothiazide tablets are bilayered and some are not?
On Googling I found this
Bilayered tablet technology separates two ...
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Decreasing Risks of MAOIs
Are Monoamine oxidase inhibitors (MAOIs) as dangerous as they are made out to be? I am new to pharmacology, but here is my understanding of MAOIs and antidepressants in general:
There is a ...
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How effective is sinovac/sinopharm vaccine
it's time for me to get vaccinated with sinovac vaccine. I am actually a little bit nervous, about its effectiveness, I am not a docotor and I have no idea what's behind it. I am worrying that it ...
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Preemptive treatment for alcohol
It's commonly accepted that most treatments for enteral poisons aren't very useful for alcohol, because it is absorbed so rapidly. For example, by the time a hospital could administer activated ...
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Does Ivermectin treat COVID-19 coronavirus infection?
Does the anti-parasitic Ivermectin work in actual human studies versus the Petri dish in vitro studies, when treating coronavirus COVID-19 infection? And if so, is it safe in humans?
An in vitro ...
