Questions tagged [medications]

Questions related to intake, use, safety, side effects, pharmacokinetics, or any other aspect of a drug prescribed by a physician.

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Are antibiotics safe during the COVID-19 pandemic?

There has been lots of news that taking the antibiotics is dangerous these days. Eg. "The Covid-19 pandemic has led to an increased use of antibiotics, which ultimately will lead to higher ...
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Why isn't paracetamol routinely combined with n-acetylcysteine?

Whether it's acute large dose paracetamol or long term regular dosage of paracetamol usage, it is a problem for the liver, ototoxic and even potentially life-threatening. While one might question the ...
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Does taking medication lose hyperfocus on ADHD?

I wonder if taking medication to deal with unconcentration on ADHD would lose hyperfocus, which is considered one of the advantage of ADHD. I understand taking medication on ADHD have a side effect ...
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Why should I avoid milk when on antibiotics?

I'm taking antibiotics (specifically, amoxicillin clavulanate) to fight off an ear infection. As she prescribed my antibiotics, my doctor told me not to eat milk products for a few days, then only eat ...
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Epidural and cholinesterase deficiency

I have pseudocholinesterase deficiency (BCHE gene), but my wife does not. My wife may need/strongly desire an epidural for our next child. Is this safe for a fetus which may possibly have the same ...
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1answer
217 views

Where does Ibuprofen inhibit COX-1, and what is its MoA?

Both ASA and Ibuprofen are COX-1 inhibitors. However, ASA inhibits the formation of the enzyme Thromboxan A2 through inhibition of COX-1 at SER 529, which is responsible for thrombocytes. That in turn ...
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Why do different pain killers have different effects on people?

I've noticed some pain killers working great for me, while other have no effect. Works for me Aspirin APC † Naproxen Doesn't work for me Paracetamol Diclofenac Tramadol I doubt there is ...
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1answer
44 views

Are antibiotics the only class of drugs whose effectiveness reduces over time?

The phenomenon of antibiotic resistance is well known: an antibiotic is effective when first introduced to the market, but over the years, its effectiveness decreases as resistant strains of bacteria ...
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1answer
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How do extended release tablets work?

I know these tablets are especially formulated and coated to dissolve over a certain period of time. I also notice that all I've seen, quite a lot, are too large to pass through the Pylorus. Do they ...
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Why is prothrombin time used to monitor warfarin and not aPTT?

Warfarin is said to change prothrombin time (PT) but not activated partial thromboplastin time (aPTT) (for practical purposes at least anyways, not really sure). But looking at the mechanism of action ...
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51 views

Mechanism of Metformin in Lactic Acidosis

High dosages of metformin and other biguanides are liked to lactic acidosis. What is the pharmacological mechanism behind this? I am aware the people have survived doses as high as 63 grams, but at ...
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How much T4 increase do you get per mcg of levothyroxine?

A normal starting dose of levothyroxine is 50 mcg per day. According to ATA, absorption is 60-80%. Let's assume 70% and let's assume 5 L of blood in the average human being. 50 mcg * 0.7 / 5.0 = 7 ...
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36 views

Why do corticosteroids have few kidney-related side effects?

Prostaglandins are involved with promoting various renal functions. Therefore, NSAIDs, like indomethacin which inhibits protaglandin formation through COX enzyme inhibition, tend to have many side-...
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Is it useless to drip Vitamin D drops on your tongue? [closed]

One celebrity doctor in my country says that Vitamin D can be absorbed only in the small intestine and that dropping Vitamin D drops on your tongue is therefore useless, because most of the liquid ...
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Have any conclusions been made regarding the interaction of Covid-19 and ACE inhibitor medications? [duplicate]

About two months ago, I started to see articles appear regarding the potential interactions between ACE inhibitor medications (commonly used to treat high blood pressure) and the severity of Covid-19 ...
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What exactly is the meaning of “No doping” sign on a drug package?

I noticed a "No doping" sign on the back of a pack of Dopamine HCl ampoules. It looks like this: I was wondering what is the purpose of this sign. I am guessing that it means that the drug should not ...
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1answer
50 views

What is the difference between Dry cough, Wet cough, Chesty Cough, Barking cough?

I am doing some research on cough sounds but my background is not health sector and I am facing issues to identify the correct type of cough. I have two doubts : Is chesty cough Wet cough? Is ...
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Are there any central trackers for COVID-19 trials?

There are several aggregate central trackers for the spread of COVID-19. Like this one, for example. Is there anything similar for trials? Or trials in the pipeline? Either vaccines or treatments?
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1answer
51 views

Why are multiple courses of isotretinoin necessary to treat acne?

The following guidances don't detail why multiple courses are more efficacious? Aug 21 2019 PRODUCT MONOGRAPH on Accutane, Hoffmann-La Roche Limited, p. 13 of 36. Effects of multiple courses of ...
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1answer
213 views

How is Lopinavir + Ritonavir expected to stop COVID-19?

There are four drugs being tested for effectiveness against COVID-19 in the SOLIDARITY trial. Three of them have obvious potential mechanisms of action: Remdesivir is an RNA polymerase inhibitor. ...
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1answer
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Is there any alternative to Accutane for acne treatment?

I have had acne for 4 years straight and it has been getting worse and worse, ever since. I've tried every trick in the book: Tea tree oil Benzoyl Peroxide Retin A (0.025%; 0.05%; 0.1%) ...
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1answer
48 views

Does Ivermectin treat COVID-19 coronavirus infection?

Does the anti-parasitic Ivermectin work in actual human studies versus the Petri dish in vitro studies, when treating coronavirus COVID-19 infection? And if so, is it safe in humans? An in vitro ...
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What are the special medications to treat Covid-19?

We know there is no cure for Covid-19 (currently) and the treatment focuses on managing symptoms as the virus runs its course. The main symptoms of Covid-19 are -Fever -Cough -Shortness of breath ...
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Can oseltamivir shorten the duration of COVID-19 and inhibit replication and transmission of the SARS-CoV-2 (2019-nCoV) virus?

Oseltamivir (tamiflu) is an antiviral medication used to treat and prevent influenza A and influenza B (flu). It is said (https://www.ncbi.nlm.nih.gov/pubmed/27660842) to reduce symptom duration even ...
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656 views

How common are tics as a side-effect when taking Lamotrigine? [closed]

I am on Lamotrogine (specifically in the form Epitec). Last week my dose was raised by 25mg (from 200mg/day to 225mg/day). Over the last couple of days I have developed a tic in my eyes. At first it ...
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Study type/design used in an coronavirus article?

I came across an article given here While I was reading the article, I wasn't able to find the study type/ design? Can you please help me find out what is the study design/type here? Meaning we ...
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1answer
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How do huge computer simulations help in medical research?

I found the there is a project Folding@home to fight against COVID-19. As far as I understand, it uses huge amount of computing power to find a cure. Why do we need such a huge number of potential ...
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1answer
2k views

Is there an interaction between methamphetamine and dental anesthetic?

According to the sign shown in this post on Reddit, using methamphetamine and dental anesthetic together is lethal. If you use Methamphetamines (Crystal Meth, Crank, Speed, Glass, Tweak, Yaba)...
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Tilt table test and beta blockers

Is tilt table test indicative with beta blockers for dysautonomia diagnosis? Or is it require drug withdrawal?
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1answer
41 views

Do patients with VAE stay in ICU for longer time?

I was reading online that people when put in ICU under mechanical ventilation, can develop Ventilated Associated Events. What I would like to know is: does the stay in ICU increase for people who ...
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1answer
94 views

Why stomach ulcer need more than one antibiotic at the same time?

Almost all treatment recommendation for gastritis, duodenitis or peptic ulcer that has Helicobacter pylori, calls for 2 or 3 antibiotic at the same time, why is that ? Why not use a single effective ...
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52 views

T2DM medication treatment pathway

I am looking at the T2DM medications specified here and have a few questions about them. 1) Why don't I see drugs like Troglitazone, Tolazamide, Acarbose, Acetohexamide, Chlorpropramide, Miglitol? ...
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Side-effects or other medical conditions for diabetic patients

I have a database of diabetic patients and their medication/lab test data as well. 1) I am planning to run a simple analysis like finding out incidence rate example: amongst the T2DM patients that I ...
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What is the process of calculating if a molecule is helpful and/or harmful to an organism?

From reading about pharmacology through the years I synthesized from my own prior research that What is the process of calculating if a molecule is helpful and/or harmful to an organism is this: A ...
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1answer
28 views

Rationale for Pilocarpine instillation after retrobulbar haemorrhage

BACKGROUND: Retrobulbar haemorrhage may occur due to retrobulbar block. Immediate pressure bandage after instilling one drop of 2% pilocarpine and postpone of operation for a week is advised. What is ...
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25 views

T2DM diagnosis vs disorder due to T2DM diagnosis?

I have a database of diabetic patients. Mostly 80 % are T2DM patients. Now I would like to identify the T2DM patients based on their conditions reported. I mean when patients visit hospital (diabetic ...
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1answer
36 views

How to interpret diabetic complications?

I have a database of diabetic patients. Mostly 80 % are T2DM patients. Now I would like to identify the T2DM patients based on their conditions reported. I mean when patients visit hospital (diabetic ...
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33 views

Is there a greater benefit as as to why an ob-gyn will prescribe a birth control with higher risk of Venous Thromboembolism?

It is already known that combined oral contraceptive (COCs) pills increase the risk of serious complications such as Venous Thromboembolism. However there are other options that have relatively much ...
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1answer
72 views

General purpose vomit response control?

Is there a general purpose antiemetic for vomit response control? Many vomit control solutions are focused on specific causes for the vomiting. Some common causes of nausea/vomiting: Cancer ...
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1answer
34 views

How does Diabetic specialist clinic work?

I am from IT domain and would like to seek some help on certain medicine related questions I would like to know how does Diabetic specialist hospital/clinic work for Diabetic patients when compared ...
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1answer
44 views

What is daily sedation interruption for ventilated patients?

I was reading about ventilator bundle here and came across this term called Daily Sedation Interruption. Does this term mean break in giving the sedation drugs? How can this help in reducing the ...
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1answer
57 views

T2DM Fasting glucose level - extreme cases

I am working on clinical data analysis and currently dealing with T2DM patients. When I look at their Fasting glucose level readings, I see that their values range from 0.9 mmol\L to 64 mmol\L The ...
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1answer
64 views

Why did it take so long to notice that Zantac had carcinogenic ingredients?

Why did it take so long to notice that Zantac had carcinogenic ingredients? Sanofi is recalling the popular heartburn drug Zantac. The generic name for the drug is Ranitidine. Apparently, the ...
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89k views

How much food is necessary to buffer the stomach when taking medicine?

Very often, doctors or pharmacists will advise patients to take certain pills with food to "act as a buffer" so the patient is less likely to get a stomach ache from taking the pill. How much food is ...
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68 views

Fluid balance range for human

I am working on clinical data analysis with patients from icu who are mechanically ventilated and in ICU for 4 or more days. Currently I tried to calculate their fluid balance based on the input and ...
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54 views

What are the main problems with non-injectable ways to administer molecules into the human body?

From past reading in various sources there seems to me to be many ways to administer molecules into the human body without injections that cause tissue trauma but that these ways generally aren't ...
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31 views

Drug dosage in pharmacology [closed]

Please give a overview about how the dosage of a particular drug (e.g. ciprofloxacin) is determined in pharmacology?
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116 views

Why many usually-very-painful medical processes aren't done under conscious, generally painless-painkilling?

Many usually-very-painful medical or medical-defined processes such as: Hair transplant Lip botox Fecal impaction removal Dental cleaning (stone removal) Aren't being done under conscious, generally ...
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32 views

Why/how are some drugs nephrotoxic?

I want to know the (more or less) exact mechanism by which specific nephrotoxic medications damage the kidneys. For some drugs it seems relatively intuitive that they interfere with the function of ...
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Why was Ergotamine (trade name: Cafergot) discontinued in Canada and UK?

My mom in HK was prescribed Ergotamine, but I'm unnerved discontinuation in Canada and UK! Something wrong with it? Asked 13 Oct 2012 by lucyglitters i live in the uk and i've been taking it for ...

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