Questions tagged [medications]

Questions related to intake, use, safety, side effects, pharmacokinetics, pharmacodynamics, drugs, prodrugs and medication.

Filter by
Sorted by
Tagged with
3
votes
2answers
230 views

Activated charcoal administered rectally?

A colleague of mine, an experienced pharmacist, told me that there used to be a product of activated charcoal called Charcodote, which could have been used either orally or rectally. I doubted this, ...
2
votes
0answers
31 views

Why do antidepressant drugs increase body mass?

Serotonin is an anorexient neurotransmitter. But if I am right, antidepressant drugs like SSRIs increase the amount of serotonin in the brain. So why do antidepressants increase body mass if ...
6
votes
2answers
147 views

Do proton pump inhibitors (PPIs) shut down all the proton pumps in all cells across our body?

It's known that proton pumps exist in all cells in our bodies and help us to get rid of damaged proteins (present a disposal system). PPIs (omeprazole, pantoprazole, esomeprazole, lansoprazole and ...
4
votes
1answer
3k views

Is there a way to stimulate taste buds after stroke?

After a stroke late last year, my 87 year-old grandfather hasn't been doing so hot. After being discharged from the hospital's rehab center, he has been in our care for over two months. Keeping food ...
1
vote
0answers
19 views

How do you know if an over the counter drug is safely processed and safe to use?

How do you know if an over the counter drug is safely processed and safe to use? I have not heard of the brand SDA Laboratories before, so tried searching online to see if it has any safety ...
3
votes
1answer
145 views

How to decide which painkiller to take?

This is a dilemma I find myself in every time I'm in need of a painkiller: should I take paracetamol (acetaminophen), ibuprofen or aspirin? I've come across several articles outlining the differences ...
1
vote
0answers
30 views

Why is Toradol no longer available in the US?

A few years ago I was given Toradol for kidney stone pain. It was magical. My friend just had a kidney stone and was given morphine, then Dilaudid. Curious about the differences, I went googling, only ...
1
vote
1answer
70 views

What is the difference between Dry cough, Wet cough, Chesty Cough, Barking cough?

I am doing some research on cough sounds but my background is not health sector and I am facing issues to identify the correct type of cough. I have two doubts : Is chesty cough Wet cough? Is ...
0
votes
0answers
24 views

Is metamizole associated with rebound headaches?

I can't find any specific mention on the internet if Metamizole (most known as dipyrone) is specifically associated with rebound headaches like other pain relieve medications like Aspirin, ...
1
vote
2answers
92 views

Can oseltamivir shorten the duration of COVID-19 and inhibit replication and transmission of the SARS-CoV-2 (2019-nCoV) virus?

Oseltamivir (Tamiflu) is an antiviral medication used to treat and prevent influenza A and influenza B (flu). It is said to reduce symptom duration even when initiated more than 2 days after symptom ...
1
vote
1answer
163 views

How effective is oseltamivir when given before symptoms of flu appear?

A day before someone gets symptoms of flu, it can already been detected that the person will get the flu, as the person is already contagious. Would an antiviral like oseltamivir (Tamiflu) then be ...
2
votes
1answer
60 views

If placebo controls work even when the patient is aware that the treatment is a placebo. Why are deceptive placebo controls used?

Placebos are “fake” treatments prescribed for the psychological benefit to the patient rather than for any physiological effect. Placebos are used for conditions defined by “self-observation” symptoms ...
3
votes
1answer
51 views

Why is methadone not prescribed with naloxone for opioid use disorder?

Two possible treatments for opioid use disorder are methadone or buprenorphine/naloxone (suboxone). According to the National Alliance of Mental Illness(https://www.nami.org/About-Mental-Illness/...
0
votes
0answers
22 views

Tick bite treatment. Doxycycline intake suspended after 3 days only. If substituted by Bactrim, is there a risk to develop bacteria resistant?

A patient was bitten by a tick and carried the tick on his skin for 5/6 days (which got engorged at the end). Then the tick dropped spontaneously. He has been prescribed a preventive antibiotic course ...
1
vote
1answer
49 views

Why are some medicines recommended to be taken with a high dose and low frequency?

Alendronate sodium is an osteoporosis medicine commonly recommended as a once-a-week 70 mg dose. Why not 35 mg twice a week? or 10 mg daily? I am guessing that a more steady intake like this would be ...
5
votes
3answers
111 views

Are there any central trackers for COVID-19 trials?

There are several aggregate central trackers for the spread of COVID-19. Like this one, for example. Is there anything similar for trials? Or trials in the pipeline? Either vaccines or treatments?
5
votes
1answer
138 views

Why does anybody still prescribe Citalopram with Escitalopram available (apart from price)?

As far as I could find Escitalopram is superior in every way, except for the US price (which might no longer even be the case). So why is the former still widely used worldwide? Did I miss anything? ...
0
votes
1answer
43 views

interaction between Mirtazapine & Mesalamine & olanzapine [closed]

Is there any adverse reaction or interaction between Mirtazapine & Mesalamine & olanzapine, If taken in low doses(mirtazapine 7.5 & Olanzapine 2.5).
0
votes
2answers
44 views

Book of drug interactions

Where can I find full list of drug _ drug interaction & adverse reaction, apart from pdr.net, I mean to say in a book form. What books of medical science contain these information? Please name a ...
6
votes
1answer
73 views

What are the long term effects of using diclofenac patches?

I wonder what the long term effects are of using diclofenac patches (e.g. one patch applied daily and kept for 24 hours positioned on the lateral epicondyle of the humerus). By long term I mean ...
0
votes
0answers
24 views

To generate induced-plutipotent stem cells you can use the Yamanaka factors or use pharmaceuticals, which is better and why?

To make this question more open, it doesn't have to be specifically the Yamanaka factors (It could be fewer than the 4, or other factors). E. g. Epigenetic eraser pharmaceuticals https://www.nature....
7
votes
1answer
233 views

How is Lopinavir + Ritonavir expected to stop COVID-19?

There are four drugs being tested for effectiveness against COVID-19 in the SOLIDARITY trial. Three of them have obvious potential mechanisms of action: Remdesivir is an RNA polymerase inhibitor. ...
2
votes
1answer
117 views

Continuing effectiveness of anti-viral drugs after shingles outbreak

When shingles is treated with famciclovir for a few weeks and the rash disappears but the pain persists, can another course of treatment with famciclovir reduce pain? If not, what other medications ...
1
vote
0answers
23 views

Where can I find a list (even if only partial) of excipients that cause a medication to be indivisible?

Certain tablet formulations should not be divided or halved because the tablets are film-coated for low pH resistance (i.e. for safe passage in the stomach) or because the active ingredient is not ...
2
votes
0answers
74 views

Is the common cold deadly to a suppressed immune system?

If you were taking an immune system suppressant such as Prograf (Tacrolimus) for a long period of time would a virus like the common cold linger in the body and cause infection over time and possibly ...
3
votes
2answers
4k views

What is the mechanism by which paracetamol improves sleep?

45+ old male sleep maintenance issues for couple of years resolved by fixing the basics- blacked out room, avoiding alcohol and coffee having the biggest effect. Still even if I am able to sleep 8 ...
7
votes
1answer
145 views

Why isn't paracetamol routinely combined with n-acetylcysteine?

Whether it's acute large dose paracetamol or long term regular dosage of paracetamol usage, it is a problem for the liver, ototoxic and even potentially life-threatening. While one might question the ...
6
votes
1answer
345 views

Does taking medication lose hyperfocus on ADHD?

I wonder if taking medication to deal with unconcentration on ADHD would lose hyperfocus, which is considered one of the advantage of ADHD. I understand taking medication on ADHD have a side effect ...
24
votes
2answers
20k views

Why should I avoid milk when on antibiotics?

I'm taking antibiotics (specifically, amoxicillin clavulanate) to fight off an ear infection. As she prescribed my antibiotics, my doctor told me not to eat milk products for a few days, then only eat ...
2
votes
0answers
169 views

Epidural and cholinesterase deficiency

I have pseudocholinesterase deficiency (BCHE gene), but my wife does not. My wife may need/strongly desire an epidural for our next child. Is this safe for a fetus which may possibly have the same ...
6
votes
1answer
233 views

Where does Ibuprofen inhibit COX-1, and what is its MoA?

Both ASA and Ibuprofen are COX-1 inhibitors. However, ASA inhibits the formation of the enzyme Thromboxan A2 through inhibition of COX-1 at SER 529, which is responsible for thrombocytes. That in turn ...
8
votes
2answers
182 views

Why do different pain killers have different effects on people?

I've noticed some pain killers working great for me, while other have no effect. Works for me Aspirin APC † Naproxen Doesn't work for me Paracetamol Diclofenac Tramadol I doubt there is ...
1
vote
1answer
52 views

Are antibiotics the only class of drugs whose effectiveness reduces over time?

The phenomenon of antibiotic resistance is well known: an antibiotic is effective when first introduced to the market, but over the years, its effectiveness decreases as resistant strains of bacteria ...
4
votes
1answer
20k views

How do extended release tablets work?

I know these tablets are especially formulated and coated to dissolve over a certain period of time. I also notice that all I've seen, quite a lot, are too large to pass through the Pylorus. Do they ...
3
votes
1answer
54 views

Why is prothrombin time used to monitor warfarin and not aPTT?

Warfarin is said to change prothrombin time (PT) but not activated partial thromboplastin time (aPTT) (for practical purposes at least anyways, not really sure). But looking at the mechanism of action ...
3
votes
1answer
53 views

Mechanism of Metformin in Lactic Acidosis

High dosages of metformin and other biguanides are liked to lactic acidosis. What is the pharmacological mechanism behind this? I am aware the people have survived doses as high as 63 grams, but at ...
6
votes
1answer
103 views

How much T4 increase do you get per mcg of levothyroxine?

A normal starting dose of levothyroxine is 50 mcg per day. According to ATA, absorption is 60-80%. Let's assume 70% and let's assume 5 L of blood in the average human being. 50 mcg * 0.7 / 5.0 = 7 ...
3
votes
1answer
57 views

Why do corticosteroids have few kidney-related side effects?

Prostaglandins are involved with promoting various renal functions. Therefore, NSAIDs, like indomethacin which inhibits protaglandin formation through COX enzyme inhibition, tend to have many side-...
1
vote
1answer
47 views

Is it useless to drip Vitamin D drops on your tongue? [closed]

One celebrity doctor in my country says that Vitamin D can be absorbed only in the small intestine and that dropping Vitamin D drops on your tongue is therefore useless, because most of the liquid ...
0
votes
0answers
23 views

Have any conclusions been made regarding the interaction of Covid-19 and ACE inhibitor medications? [duplicate]

About two months ago, I started to see articles appear regarding the potential interactions between ACE inhibitor medications (commonly used to treat high blood pressure) and the severity of Covid-19 ...
2
votes
0answers
46 views

What exactly is the meaning of “No doping” sign on a drug package?

I noticed a "No doping" sign on the back of a pack of Dopamine HCl ampoules. It looks like this: I was wondering what is the purpose of this sign. I am guessing that it means that the drug should not ...
1
vote
1answer
31 views

Prevent-Release Systems for Opioid Painkillers Vs Placebo

today we were studying oral novel drug delivery systems. The class was prerecorded (due to pandemic) There was this table in the slides "strategies and benefits of modifying drug release table" and I ...
2
votes
1answer
54 views

Why are multiple courses of isotretinoin necessary to treat acne?

The following guidances don't detail why multiple courses are more efficacious? Aug 21 2019 PRODUCT MONOGRAPH on Accutane, Hoffmann-La Roche Limited, p. 13 of 36. Effects of multiple courses of ...
3
votes
1answer
214 views

Is there any alternative to Accutane for acne treatment?

I have had acne for 4 years straight and it has been getting worse and worse, ever since. I've tried every trick in the book: Tea tree oil Benzoyl Peroxide Retin A (0.025%; 0.05%; 0.1%) ...
1
vote
1answer
55 views

Does Ivermectin treat COVID-19 coronavirus infection?

Does the anti-parasitic Ivermectin work in actual human studies versus the Petri dish in vitro studies, when treating coronavirus COVID-19 infection? And if so, is it safe in humans? An in vitro ...
0
votes
2answers
104 views

What are the special medications to treat Covid-19?

We know there is no cure for Covid-19 (currently) and the treatment focuses on managing symptoms as the virus runs its course. The main symptoms of Covid-19 are -Fever -Cough -Shortness of breath ...
4
votes
1answer
785 views

How common are tics as a side-effect when taking Lamotrigine? [closed]

I am on Lamotrogine (specifically in the form Epitec). Last week my dose was raised by 25mg (from 200mg/day to 225mg/day). Over the last couple of days I have developed a tic in my eyes. At first it ...
2
votes
1answer
70 views

ACE2 Inhibition as therapeutic candidate?

Disclaimer: I am a scientist, but this is not my main field so sorry if I've not used the correct terminology at this busy time... Since the coronavirus protein bonds with and gains entry to the cell ...
0
votes
0answers
19 views

Study type/design used in an coronavirus article?

I came across an article given here While I was reading the article, I wasn't able to find the study type/ design? Can you please help me find out what is the study design/type here? Meaning we ...
2
votes
1answer
21 views

How do huge computer simulations help in medical research?

I found the there is a project Folding@home to fight against COVID-19. As far as I understand, it uses huge amount of computing power to find a cure. Why do we need such a huge number of potential ...

1
2 3 4 5
8