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Questions tagged [medications]

Questions related to intake, use, safety, side effects, pharmacokinetics, pharmacodynamics, drugs, prodrugs and medication.

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Why do blood vessels have M3 Receptors that can only be stimulated exogenously?

I'm going through pharmacology and this detail that our lecturer sort of brushed over sort of baffled me? As far as I understand, endogenous means being stimulated by the body as part of a synapse, ...
Dr. Swag's user avatar
-2 votes
0 answers
26 views

Accidently spilled someone else's medicine on my hand [closed]

I was injecting some medicine to my dog, IV, and accidently spilled some of it on my hand. My hand smells of medicine now, and even though I have washed it several times the smell doesn't go. This is ...
Iskander's user avatar
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56 views

Why might caphosol super-saturated calcium phosphate mouthrinse have to be used immediately after mixing?

I have been using a compounded prescription caphosol super-saturated calcium phosphate mouthrinse (prescribed for the purpose of tooth remineralization to offset the effects of tooth grinding). The ...
user10478's user avatar
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2 votes
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How can Spinraza be effective on peripheral motor neurons outside of the spinal cord if it cannot penetrate the blood-brain barrier?

I have SMA type 3. I had four intrathecal Nusinersen injections but I had no noticable improvement. I have doubts about its effectiveness outside of spinal cord, because we know that Spinraza can not ...
kenn's user avatar
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Isotretinoin Contraindications [closed]

Why is Isotretinoin (Accutane) contraindicated in migraine patients? I’ve seen many doctors saying that you should not take isotretinoin if you have a migraine, is there a reason behind it?
Shadow Nik's user avatar
3 votes
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40 views

Does treatment with one triazole give resistance to all other triazoles?

Let's say a patient is treated with a triazole (e.g. Itraconazole) for an oral thrush infection and the fungus acquires resistance to it, then is that resistance against other triazoles too (e.g. ...
user96551's user avatar
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1 vote
1 answer
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Would an injection into the neck be useful for quick application of a drug?

This might be the wrong place to ask, but I'm working on a story where the main character has a chronic condition that is usually managed by medication. However, on the off chance they run out of ...
Geoffrey Williams's user avatar
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Can zyprexa cause thinning of brain cortex

Aka olanzapine. It’s a commonly prescribed anti psychotic, I’ve seen written in a couple of places that it thins brain cortex ……..
PsychPanda's user avatar
2 votes
2 answers
186 views

Does skin picking cause skin cancer?

I was a skin picker (Dermatillomaniac) since several years ago. Of course I pick only the skin of my hand thumbs. I wish to quit it and I wish to know about two things here: Does chronic skin picking ...
Snack Exchange's user avatar
1 vote
0 answers
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How to handle inverse agonism when calculating bias?

Is there a standard way to compare an inverse agonist to an agonist in a bias calculation? The problem is that inverse agonists have negative efficacy, so you can't take the log to calculate RA... ...
user26943's user avatar
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Vitamin B3 and staph

In 2015, researchers found that vitamin B3 might help aid in fighting staph bacteria. Has there been any progress on this since then?
Riemann's user avatar
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Are treatments for (hyper/hypo)parathyroidism mutually exclusive from treatmeants to (hyper/hypo)calcemia?

Summarized in the table below the drugs that were listed in my professor's lecture slides for the treatment of Hyperparathyroidism (first column) and hypoparathyroidism (second column) Are treatments ...
Doe Pull's user avatar
3 votes
0 answers
95 views

Why can't Asian flush be treated in a similar way to lactose intolerance?

I have been reading about the Asian flush, which is caused by a histamine reaction to a toxic byproduct of alcohol metabolism, acetaldehyde. Some individuals are able to suppress the histamine ...
Jacob T's user avatar
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78 views

Are there medications that treat premature ejaculation without interfering in serotonin levels?

The widespread medications that are being used to treat premature ejaculation (PE) are kind of antidepressants called SSRIs (Selective Serotonin Reuptake Inhibitors). But the problem with this kind of ...
Snack Exchange's user avatar
3 votes
1 answer
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Analgesics are drugs which relieve pain. Are there other drugs which do the opposite -- make you more sensitive to pain?

I am curious. Are there durgs which do the opposite of analgesics? That is, make you more sensitive to pain, but don't cause pain themselves? If so, what is this class of drugs called? What is the ...
Árni Dagur's user avatar
1 vote
0 answers
12 views

IPSD, IISD, MPP1+ and MSI scores [closed]

First of all, sorry if this is not the correct Stack. I am translating a clinical protocol for an antibody that could be used against certain types of cancer. I found the following and I have no idea ...
Lilo's user avatar
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5 votes
1 answer
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Why do calcium channel blockers have an adverse effect of edema but Beta Blockers do not cause edema as a side effect?

My pharmacology professor glossed over the mechanism that causes edema besides briefly discussing after/preload. If Calcium channel blockers and beta blockers both are negative ionotropes then why isn'...
Justin Edward's user avatar
1 vote
1 answer
900 views

Why is there HBr in dextromethorphan HBr?

I was reading off the back label of a Nyquil bottle and I realized instead of dextromethorphan, it said dextromethorphan HBr. I also realized that instead of phenylephrine, it said phenylephrine HCl. ...
gagagaga's user avatar
4 votes
0 answers
57 views

Do topical anti-inflamatory preparations work topically?

There are topical anti-inflamatory preparations where the advertising at least implies that they work topically, in that the effect will be more localised by the use of a topical preparation than if ...
User65535's user avatar
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Could some common allergies be treated medicinally without antihistamins/steroids/epinephrine and if so how?

A common allergy such as house dust-mite allergy or a food allergy can be treated with antihistamines, steroids and epinephrine. I understand that there are Mast cell stabilizers and Anti-leuko-...
houdy's user avatar
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-4 votes
1 answer
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Lack of studies on small doses of chlorine dioxide as treatment for diseases

While ingesting high doses of chlorine dioxide are toxic to humans, this is not the case for smaller doses. Ingesting, for example, 30 mg per day for a few days would probably not result in serious ...
Riemann's user avatar
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0 answers
35 views

How do blood substitute increase the risk of stroke?

When describing blood substitute's (BS's) made of perfluorocarbons use in clinical trials, one of the most commonly described side effected in the increase risk of stroke in the area were the PFC is ...
user avatar
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Definition of fasted state

Is there a general definition what consists a fasted state? The medical literature I have read so far uses the term ambiguously, i.e. from overnight abstinence to 2h of no food intake. Is there a ...
CuriousIndeed's user avatar
1 vote
1 answer
54 views

Is generic name a synonym for active ingredient?

What is the difference between active ingredient and generic name? Is generic name always equal to the active ingredients or are these sometimes different? For example, Benadryl has a generic name, ...
Frank's user avatar
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Why have we obtained significantly different results for moisture content on two different brands of moisture analyzers?

Our pharmaceutical laboratory has two moisture analyzers in use; one is Shimadzu MOC3u (MC-A), and the other is Mettler-Toledo HC103 (MC-B). A sample from the same batch was put on each instrument to ...
eli's user avatar
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2 votes
1 answer
96 views

How to estimate equivalent doses of similar medicines with different route of administration?

I am trying to compare the two medications used as rescue medications for seizures 5mg Rectal Diazepam 2.5mg Buccal Midazolam (Buccolam) I am aware that Midazolam is considered to be more potent than ...
Dilitante's user avatar
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4 votes
1 answer
103 views

Would slight shifting of administration times of Paxlovid impact its efficacy?

Paxlovid (nirmatrelvir/ritonavir) is an oral medication indicated for patients recently diagnosed with COVID-19 and who are at high risk of deterioration. This drug received an emergency use ...
Don_S's user avatar
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2 votes
1 answer
101 views

Why do so many OTC drugs have one-size-fits-all dosing instructions?

Every over-the-counter medication I've seen in recent memory (in the USA) has had instructions along the lines of, "Adults and children 12 years and older: 1 pill every 4 hours, 12 and under: ...
fretzeldurmf's user avatar
2 votes
0 answers
57 views

Does a Doctor exist that is able to encapsulate triaging differing specialities? [closed]

My girlfriend has multiple health issues: ASD ADHD BPD Type 1 Diabetes Wolf Parkinsons Disease Non-alcoholic fatty liver disease fibromyalgia Perferatted Valve Reynauds Disease The issue is each one ...
ArcherGilly's user avatar
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1 answer
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Has there been any medical studies as to whether drinking a 'Hot Toddy' can help to ward off or to help heal someone who has COVID-19? [closed]

I am curious to know if there has been any medical studies that have been conducted to ascertain if drinking a 'Hot Toddy' every day will decrease the odds of someone being infected by the COVID-19 ...
user57467's user avatar
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0 answers
30 views

What are the basic reasons for normogonadotropic hypogonadism?

I'm can't fine the full known scope of reasons of male normogonadotropic hypogonadism. From this article I see the two basic reasons: Gonadal dysgenesis variants (residually functioning ovarian ...
red0ct's user avatar
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8 votes
1 answer
101 views

Why are Drugs.com side-effect incidence rates so different from manufacturer/FDA reports?

Entries at Drugs.com have a section on "Side Effects... For Healthcare Professionals" which present percentages for incidence rates of side effects. However, I've found that the rates ...
Daniel R. Collins's user avatar
5 votes
2 answers
683 views

Ritalin/Concerta/Methylphenidate is an amphetamine?

FIDE (the governing body of international chess competition) says here: The most relevant banned substances for chess are: • Amphetamines – e.g. Adderall, Ritalin (...) Image: I think either ...
BCLC's user avatar
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0 votes
1 answer
62 views

H1-antihistamines classified according to pharmacology?

I've been researching H1-antihistamines for personal reasons. And I'm trying to find out if H1-antihistamines are sorted based on pharmacology. I understand that H1-antihistamines have up to three ...
Stardust's user avatar
0 votes
0 answers
21 views

Amino acid data - 101 for beginners

I am a data analyst who received amino acid data from lab to transform them into a form suitable for analysis. What I would like to check with you is check whether the below terms mean the same? For ...
The Great's user avatar
  • 309
-4 votes
1 answer
141 views

How do I stop my doctor from killing me? [closed]

In the international best-selling author, Dr Vernon Coleman's book 'how to stop your doctor killing you', he explains that the person most likely to kill you is not a burglar, a mugger, a deranged ...
Tyler's user avatar
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1 vote
0 answers
49 views

What is the state of transmissible vaccines?

I was thinking about viral gain of function research -- and firebugs playing with matches -- when it hit me: if a highly contagious, but harmless version were engineered it could outcompete more ...
thegreatwhatsit's user avatar
0 votes
1 answer
455 views

Why are some tablets Telmisartan, Amlodipine and Hydrochlorothiazide bilayered and some are not?

I recently saw that some brands of Telmisartan, Amlodipine and Hydrochlorothiazide tablets are bilayered and some are not? On Googling I found this Bilayered tablet technology separates two ...
user avatar
0 votes
1 answer
68 views

How effective is sinovac/sinopharm vaccine

it's time for me to get vaccinated with sinovac vaccine. I am actually a little bit nervous, about its effectiveness, I am not a docotor and I have no idea what's behind it. I am worrying that it ...
dato nefaridze's user avatar
0 votes
1 answer
65 views

Decreasing Risks of MAOIs

Are Monoamine oxidase inhibitors (MAOIs) as dangerous as they are made out to be? I am new to pharmacology, but here is my understanding of MAOIs and antidepressants in general: There is a ...
user avatar
3 votes
1 answer
76 views

Monotherapy of multiple drugs or combination therapy - Beginner 101

Let's say that patient A is taking drugs like as shown below |---atenolol-----esmolol----nebivolol---------------------| |---s------e-----s-----e----s-------e---------------------| here s and e ...
The Great's user avatar
  • 309
1 vote
0 answers
39 views

Does Remdesivir really go bad after reconstitution with sterile water?

I was recently looking at how long can Remdesivir be stored in its different forms. I came up across several articles provided by the FDA and Gilead Sciences and others. What caught my eye was the ...
ATheCoder's user avatar
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1 vote
1 answer
29 views

How can an individual seek to get an idea investigated as a potential treatment, or seek a change in a particular guideline?

It would be dangerous for the general public to provide advice on 'what they reckon' would be a good treatment or a good guideline for medical advice; and that has clearly caused problems in the past. ...
atreeon's user avatar
  • 109
0 votes
1 answer
49 views

Is there a free vaccine or medicinal product database?

Is there a database that allows me to query for available vaccine products by ingredients? For instance, I want to find an available vaccine product that contains "Streptococcus pneumoniae ...
Franz Wahr's user avatar
0 votes
1 answer
372 views

What is the average optimal time interval before or after a meal when medicines should be taken?

Many medicines and supplements specify that they should be taken either before of after a meal—and I know that this means some time must pass, not gulping the med immediately next to the meal. However,...
aaa's user avatar
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1 vote
0 answers
19 views

Effects of anti-Rh(D) antibodies on the fetus

Rh disease is caused by the irruption in the fetal circulation of anti-Rh(D) antibodies. This only happens when there has been a prior exposure of the mother to Rh+ RBC. To prevent Rh sensitization ...
user47679's user avatar
2 votes
1 answer
66 views

Are there any randomized clinical trials being conducted on TMPRSS2 inhibitors for Covid-19 treatment?

In a recent paper on why hydroxychloroquine doesn't really work against Covid-19, it's been demonstrated that SARS-CoV-2 is much better at taking advantage of TMPRSS2 at the cell membrane surface, so ...
got trolled too much this week's user avatar
0 votes
1 answer
35 views

How to evaluate long-term safety of biological interventions?

I'm wondering how to go about evaluating the long term effects of a biological intervention, like a new therapeutic. There is emergent evidence that common medications like NSAIDs or anticholinergics ...
Kush Sharma's user avatar
7 votes
1 answer
203 views

How do mRNA vaccines work and what are their advantages over traditional vaccines?

How do mRNA vaccines work? To my intuitive understanding, for an mRNA vaccine to work, the mRNAs injected into the patient need to first enter a cell and get translated into proteins. Those proteins ...
Remi.b's user avatar
  • 483
1 vote
1 answer
304 views

Does L-theanine increase caffeine's half-life?

Does consuming L-theanine with caffeine, either in drink (like matcha) or in pill form, affect the half-life of caffeine? All I can find about these substances ares claims that L-theanine slows the ...
João Bravo's user avatar

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