Questions tagged [medications]

Questions related to intake, use, safety, side effects, pharmacokinetics, pharmacodynamics, drugs, prodrugs and medication.

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19 views

Does Remdesivir really go bad after reconstitution with sterile water?

I was recently looking at how long can Remdesivir be stored in its different forms. I came up across several articles provided by the FDA and Gilead Sciences and others. What caught my eye was the ...
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why are pain killers as a whole so addictive?

It seems that almost every painkiller medication that I can think of has some addictive qualities, such as morphine and panadol and many others. just now I have realised that medical marijuana is ...
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Were any drugs completely withdrawn from market only due to accidental/incorrect administration resulting in serious adverse events (incl. death)?

I know the "bupivacaine story" which [in some countries] was withdrawn from IVRA [intravenous regional anesthesia] use (aka Bier block) following some deaths, but still, for instance... ...
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22 views

How can an individual seek to get an idea investigated as a potential treatment, or seek a change in a particular guideline?

It would be dangerous for the general public to provide advice on 'what they reckon' would be a good treatment or a good guideline for medical advice; and that has clearly caused problems in the past. ...
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6 views

Studies of Dyprione effects after long storage period?

Dyprione/Metamizole is common as the active ingredient of analgesics - in some countries. It also has some adverse potential side effects, such as agranulocytosis (or more specifically Neutropenia). ...
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47 views

Is there a free vaccine or medicinal product database?

Is there a database that allows me to query for available vaccine products by ingredients? For instance, I want to find an available vaccine product that contains "Streptococcus pneumoniae ...
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29 views

What is the average optimal time interval before or after a meal when medicines should be taken?

Many medicines and supplements specify that they should be taken either before of after a meal—and I know that this means some time must pass, not gulping the med immediately next to the meal. However,...
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35 views

Which is the best test to confirm a Lidocaine allergy?

As per my study, there are two tests which are performed to confirm/dispute a Lidocaine allergy. Patch test Intradermal Test Which is the most conclusive of the above? Are there any other tests?
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How likely an incomplete antibiotic treatment leads to antibiotic resitance?

We all heard of the danger of antibiotic resistance in bacterial infection, if the antibiotic treatment is stopped too early, but are there any quantitative studies on the likelihood of that? I ...
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12 views

Effects of anti-Rh(D) antibodies on the fetus

Rh disease is caused by the irruption in the fetal circulation of anti-Rh(D) antibodies. This only happens when there has been a prior exposure of the mother to Rh+ RBC. To prevent Rh sensitization ...
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27 views

Are there any randomized clinical trials being conducted on TMPRSS2 inhibitors for Covid-19 treatment?

In a recent paper on why hydroxychloroquine doesn't really work against Covid-19, it's been demonstrated that SARS-CoV-2 is much better at taking advantage of TMPRSS2 at the cell membrane surface, so ...
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31 views

How to evaluate long-term safety of biological interventions?

I'm wondering how to go about evaluating the long term effects of a biological intervention, like a new therapeutic. There is emergent evidence that common medications like NSAIDs or anticholinergics ...
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101 views

How do mRNA vaccines work and what are their advantages over traditional vaccines?

How do mRNA vaccines work? To my intuitive understanding, for an mRNA vaccine to work, the mRNAs injected into the patient need to first enter a cell and get translated into proteins. Those proteins ...
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1answer
70 views

Does L-theanine increase caffeine's half-life?

Does consuming L-theanine with caffeine, either in drink (like matcha) or in pill form, affect the half-life of caffeine? All I can find about these substances ares claims that L-theanine slows the ...
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13 views

Why do SSRI antidepressants cause a reduction in sex drive? [duplicate]

Drugs in this class are Prozac(fluoxetine), Zoloft (setraline), Lexapro (escitalopram) and many more. I've had the experience of using Prozac and Zoloft. I found that within two weeks, my ability to ...
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61 views

Can an individual survive methanol poisoning if the drink is mixed with isopropanol? [closed]

I have a friend who last year suffered severe drug addiction and decided to consume windshield washer fluid that contains methanol/isopropanol. He drank it from Saturday to Wednseday before being ...
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37 views

What are the most expensive medications to manufacture?

I'm aware that the chief reason likely the vast majority of ludicrously priced medications are as such, is not because they're expensive to produce per se, but because pharmaceutical companies have to ...
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43 views

Is there a relationship between slope of the plasma concentration-time curve and addictiveness?

I've been reading about addiction medicine, and a lot of the discussion on pharmacokinetics seems to imply a truth that is never actually stated in words. Background: The Plasma Concentration vs. Time ...
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80 views

Is calling dexamethasone a “psychoactive steroid medication” correct use of the term psychoactive? Because it has reported psychological side effects?

Pete Buttigieg has a decent educational and professional background and good command of the English language and some appreciation for facts, which is why I call this choice of words into question and ...
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397 views

Activated charcoal administered rectally?

A colleague of mine, an experienced pharmacist, told me that there used to be a product of activated charcoal called Charcodote, which could have been used either orally or rectally. I doubted this, ...
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33 views

Why do antidepressant drugs increase body mass?

Serotonin is an anorexient neurotransmitter. But if I am right, antidepressant drugs like SSRIs increase the amount of serotonin in the brain. So why do antidepressants increase body mass if ...
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1answer
50 views

How do you know if an over the counter drug is safely processed and safe to use?

How do you know if an over the counter drug is safely processed and safe to use? I have not heard of the brand SDA Laboratories before, so tried searching online to see if it has any safety ...
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26 views

Is metamizole associated with rebound headaches?

I can't find any specific mention on the internet if Metamizole (most known as dipyrone) is specifically associated with rebound headaches like other pain relieve medications like Aspirin, ...
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1answer
73 views

If placebo controls work even when the patient is aware that the treatment is a placebo. Why are deceptive placebo controls used?

Placebos are “fake” treatments prescribed for the psychological benefit to the patient rather than for any physiological effect. Placebos are used for conditions defined by “self-observation” symptoms ...
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26 views

Tick bite treatment. Doxycycline intake suspended after 3 days only. If substituted by Bactrim, is there a risk to develop bacteria resistant?

A patient was bitten by a tick and carried the tick on his skin for 5/6 days (which got engorged at the end). Then the tick dropped spontaneously. He has been prescribed a preventive antibiotic course ...
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50 views

Why are some medicines recommended to be taken with a high dose and low frequency?

Alendronate sodium is an osteoporosis medicine commonly recommended as a once-a-week 70 mg dose. Why not 35 mg twice a week? or 10 mg daily? I am guessing that a more steady intake like this would be ...
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46 views

Book of drug interactions

Where can I find full list of drug _ drug interaction & adverse reaction, apart from pdr.net, I mean to say in a book form. What books of medical science contain these information? Please name a ...
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48 views

interaction between Mirtazapine & Mesalamine & olanzapine [closed]

Is there any adverse reaction or interaction between Mirtazapine & Mesalamine & olanzapine, If taken in low doses(mirtazapine 7.5 & Olanzapine 2.5).
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52 views

Why is methadone not prescribed with naloxone for opioid use disorder?

Two possible treatments for opioid use disorder are methadone or buprenorphine/naloxone (suboxone). According to the National Alliance of Mental Illness(https://www.nami.org/About-Mental-Illness/...
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25 views

To generate induced-plutipotent stem cells you can use the Yamanaka factors or use pharmaceuticals, which is better and why?

To make this question more open, it doesn't have to be specifically the Yamanaka factors (It could be fewer than the 4, or other factors). E. g. Epigenetic eraser pharmaceuticals https://www.nature....
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24 views

Where can I find a list (even if only partial) of excipients that cause a medication to be indivisible?

Certain tablet formulations should not be divided or halved because the tablets are film-coated for low pH resistance (i.e. for safe passage in the stomach) or because the active ingredient is not ...
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1answer
54 views

Are antibiotics the only class of drugs whose effectiveness reduces over time?

The phenomenon of antibiotic resistance is well known: an antibiotic is effective when first introduced to the market, but over the years, its effectiveness decreases as resistant strains of bacteria ...
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34 views

How can I link drugs to diagnoses (ICD-10)?

I would like to be able to find a list of drugs (identified by NDC or RXNORM, SNOMED, MESH), which can treat a given diagnosis (ICD-9/10) and vice-versa - given a drug, obtain all diagnoses that can ...
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1answer
64 views

Why do corticosteroids have few kidney-related side effects?

Prostaglandins are involved with promoting various renal functions. Therefore, NSAIDs, like indomethacin which inhibits protaglandin formation through COX enzyme inhibition, tend to have many side-...
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102 views

Why is prothrombin time used to monitor warfarin and not aPTT?

Warfarin is said to change prothrombin time (PT) but not activated partial thromboplastin time (aPTT) (for practical purposes at least anyways, not really sure). But looking at the mechanism of action ...
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1answer
51 views

Is it useless to drip Vitamin D drops on your tongue? [closed]

One celebrity doctor in my country says that Vitamin D can be absorbed only in the small intestine and that dropping Vitamin D drops on your tongue is therefore useless, because most of the liquid ...
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23 views

Have any conclusions been made regarding the interaction of Covid-19 and ACE inhibitor medications? [duplicate]

About two months ago, I started to see articles appear regarding the potential interactions between ACE inhibitor medications (commonly used to treat high blood pressure) and the severity of Covid-19 ...
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46 views

What exactly is the meaning of “No doping” sign on a drug package?

I noticed a "No doping" sign on the back of a pack of Dopamine HCl ampoules. It looks like this: I was wondering what is the purpose of this sign. I am guessing that it means that the drug should not ...
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1answer
31 views

Prevent-Release Systems for Opioid Painkillers Vs Placebo

today we were studying oral novel drug delivery systems. The class was prerecorded (due to pandemic) There was this table in the slides "strategies and benefits of modifying drug release table" and I ...
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229 views

Does Ivermectin treat COVID-19 coronavirus infection?

Does the anti-parasitic Ivermectin work in actual human studies versus the Petri dish in vitro studies, when treating coronavirus COVID-19 infection? And if so, is it safe in humans? An in vitro ...
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1answer
247 views

How is Lopinavir + Ritonavir expected to stop COVID-19?

There are four drugs being tested for effectiveness against COVID-19 in the SOLIDARITY trial. Three of them have obvious potential mechanisms of action: Remdesivir is an RNA polymerase inhibitor. ...
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1answer
59 views

Why are multiple courses of isotretinoin necessary to treat acne?

The following guidances don't detail why multiple courses are more efficacious? Aug 21 2019 PRODUCT MONOGRAPH on Accutane, Hoffmann-La Roche Limited, p. 13 of 36. Effects of multiple courses of ...
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111 views

What are the special medications to treat Covid-19?

We know there is no cure for Covid-19 (currently) and the treatment focuses on managing symptoms as the virus runs its course. The main symptoms of Covid-19 are -Fever -Cough -Shortness of breath ...
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71 views

ACE2 Inhibition as therapeutic candidate?

Disclaimer: I am a scientist, but this is not my main field so sorry if I've not used the correct terminology at this busy time... Since the coronavirus protein bonds with and gains entry to the cell ...
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121 views

Are there any central trackers for COVID-19 trials?

There are several aggregate central trackers for the spread of COVID-19. Like this one, for example. Is there anything similar for trials? Or trials in the pipeline? Either vaccines or treatments?
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Can oseltamivir shorten the duration of COVID-19 and inhibit replication and transmission of the SARS-CoV-2 (2019-nCoV) virus?

Oseltamivir (Tamiflu) is an antiviral medication used to treat and prevent influenza A and influenza B (flu). It is said to reduce symptom duration even when initiated more than 2 days after symptom ...
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1answer
24 views

How do huge computer simulations help in medical research?

I found the there is a project Folding@home to fight against COVID-19. As far as I understand, it uses huge amount of computing power to find a cure. Why do we need such a huge number of potential ...
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36 views

Tilt table test and beta blockers

Is tilt table test indicative with beta blockers for dysautonomia diagnosis? Or is it require drug withdrawal?
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44 views

Side-effects or other medical conditions for diabetic patients

I have a database of diabetic patients and their medication/lab test data as well. 1) I am planning to run a simple analysis like finding out incidence rate example: amongst the T2DM patients that I ...
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59 views

T2DM medication treatment pathway

I am looking at the T2DM medications specified here and have a few questions about them. 1) Why don't I see drugs like Troglitazone, Tolazamide, Acarbose, Acetohexamide, Chlorpropramide, Miglitol? ...

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