Questions tagged [medications]
Questions related to intake, use, safety, side effects, pharmacokinetics, pharmacodynamics, drugs, prodrugs and medication.
389
questions
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15 views
Why there is histamine release following d-TC administration?
Skeletal muscle relaxants (specifically Isoquinoline derivatives like d-Tubocuriarine) liberate Histamine from Mast cells.
Ref: https://pubmed.ncbi.nlm.nih.gov/2581878/
What is the mechanism of this ...
-4
votes
1answer
38 views
How do I stop my doctor from killing me? [closed]
In the international best-selling author, Dr Vernon Coleman's book 'how to stop your doctor killing you', he explains that the person most likely to kill you is not a burglar, a mugger, a deranged ...
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0answers
40 views
What is the state of transmissible vaccines?
I was thinking about viral gain of function research -- and firebugs playing with matches -- when it hit me: if a highly contagious, but harmless version were engineered it could outcompete more ...
2
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0answers
31 views
Any statistics on the likelihood of, consumption frequencies and dosages required for serotonin syndrome to occur with LSD? [migrated]
This may be too obscure of a question to have sufficient, if any, statistics on it. If that's the case, any relevant information is appreciated.
From what I've gathered, very high doses and/or very ...
0
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1answer
70 views
Why are some tablets Telmisartan, Amlodipine and Hydrochlorothiazide bilayered and some are not?
I recently saw that some brands of Telmisartan, Amlodipine and Hydrochlorothiazide tablets are bilayered and some are not?
On Googling I found this
Bilayered tablet technology separates two ...
0
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1answer
57 views
How effective is sinovac/sinopharm vaccine
it's time for me to get vaccinated with sinovac vaccine. I am actually a little bit nervous, about its effectiveness, I am not a docotor and I have no idea what's behind it. I am worrying that it ...
0
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1answer
65 views
Decreasing Risks of MAOIs
Are Monoamine oxidase inhibitors (MAOIs) as dangerous as they are made out to be? I am new to pharmacology, but here is my understanding of MAOIs and antidepressants in general:
There is a ...
2
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1answer
16 views
Monotherapy of multiple drugs or combination therapy - Beginner 101
Let's say that patient A is taking drugs like as shown below
|---atenolol-----esmolol----nebivolol---------------------|
|---s------e-----s-----e----s-------e---------------------|
here s and e ...
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27 views
Does Remdesivir really go bad after reconstitution with sterile water?
I was recently looking at how long can Remdesivir be stored in its different forms.
I came up across several articles provided by the FDA and Gilead Sciences and others.
What caught my eye was the ...
0
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0answers
15 views
Were any drugs completely withdrawn from market only due to accidental/incorrect administration resulting in serious adverse events (incl. death)?
I know the "bupivacaine story" which [in some countries] was withdrawn from IVRA [intravenous regional anesthesia] use (aka Bier block) following some deaths, but still, for instance...
...
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1answer
24 views
How can an individual seek to get an idea investigated as a potential treatment, or seek a change in a particular guideline?
It would be dangerous for the general public to provide advice on 'what they reckon' would be a good treatment or a good guideline for medical advice; and that has clearly caused problems in the past. ...
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6 views
Studies of Dyprione effects after long storage period?
Dyprione/Metamizole is common as the active ingredient of analgesics - in some countries. It also has some adverse potential side effects, such as agranulocytosis (or more specifically Neutropenia).
...
0
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1answer
47 views
Is there a free vaccine or medicinal product database?
Is there a database that allows me to query for available vaccine products by ingredients?
For instance, I want to find an available vaccine product that contains "Streptococcus pneumoniae ...
0
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0answers
29 views
What is the average optimal time interval before or after a meal when medicines should be taken?
Many medicines and supplements specify that they should be taken either before of after a meal—and I know that this means some time must pass, not gulping the med immediately next to the meal. However,...
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37 views
Which is the best test to confirm a Lidocaine allergy?
As per my study, there are two tests which are performed to confirm/dispute a Lidocaine allergy.
Patch test
Intradermal Test
Which is the most conclusive of the above? Are there any other tests?
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8 views
How likely an incomplete antibiotic treatment leads to antibiotic resitance?
We all heard of the danger of antibiotic resistance in bacterial infection, if the antibiotic treatment is stopped too early, but are there any quantitative studies on the likelihood of that? I ...
1
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0answers
14 views
Effects of anti-Rh(D) antibodies on the fetus
Rh disease is caused by the irruption in the fetal circulation of anti-Rh(D) antibodies. This only happens when there has been a prior exposure of the mother to Rh+ RBC. To prevent Rh sensitization ...
1
vote
1answer
38 views
Are there any randomized clinical trials being conducted on TMPRSS2 inhibitors for Covid-19 treatment?
In a recent paper on why hydroxychloroquine doesn't really work against Covid-19, it's been demonstrated that SARS-CoV-2 is much better at taking advantage of TMPRSS2 at the cell membrane surface, so ...
0
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1answer
32 views
How to evaluate long-term safety of biological interventions?
I'm wondering how to go about evaluating the long term effects of a biological intervention, like a new therapeutic. There is emergent evidence that common medications like NSAIDs or anticholinergics ...
6
votes
1answer
120 views
How do mRNA vaccines work and what are their advantages over traditional vaccines?
How do mRNA vaccines work?
To my intuitive understanding, for an mRNA vaccine to work, the mRNAs injected into the patient need to first enter a cell and get translated into proteins. Those proteins ...
1
vote
1answer
81 views
Does L-theanine increase caffeine's half-life?
Does consuming L-theanine with caffeine, either in drink (like matcha) or in pill form, affect the half-life of caffeine?
All I can find about these substances ares claims that L-theanine slows the ...
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0answers
13 views
Why do SSRI antidepressants cause a reduction in sex drive? [duplicate]
Drugs in this class are Prozac(fluoxetine), Zoloft (setraline), Lexapro (escitalopram) and many more. I've had the experience of using Prozac and Zoloft. I found that within two weeks, my ability to ...
2
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1answer
63 views
Can an individual survive methanol poisoning if the drink is mixed with isopropanol? [closed]
I have a friend who last year suffered severe drug addiction and decided to consume windshield washer fluid that contains methanol/isopropanol. He drank it from Saturday to Wednseday before being ...
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0answers
38 views
What are the most expensive medications to manufacture?
I'm aware that the chief reason likely the vast majority of ludicrously priced medications are as such, is not because they're expensive to produce per se, but because pharmaceutical companies have to ...
4
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1answer
48 views
Is there a relationship between slope of the plasma concentration-time curve and addictiveness?
I've been reading about addiction medicine, and a lot of the discussion on pharmacokinetics seems to imply a truth that is never actually stated in words.
Background: The Plasma Concentration vs. Time ...
-1
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1answer
82 views
Is calling dexamethasone a “psychoactive steroid medication” correct use of the term psychoactive? Because it has reported psychological side effects?
Pete Buttigieg has a decent educational and professional background and good command of the English language and some appreciation for facts, which is why I call this choice of words into question and ...
3
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2answers
466 views
Activated charcoal administered rectally?
A colleague of mine, an experienced pharmacist, told me that there used to be a product of activated charcoal called Charcodote, which could have been used either orally or rectally. I doubted this, ...
2
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0answers
33 views
Why do antidepressant drugs increase body mass?
Serotonin is an anorexient neurotransmitter. But if I am right, antidepressant drugs like SSRIs increase the amount of serotonin in the brain.
So why do antidepressants increase body mass if ...
2
votes
1answer
52 views
How do you know if an over the counter drug is safely processed and safe to use?
How do you know if an over the counter drug is safely processed and safe to use?
I have not heard of the brand SDA Laboratories before, so tried searching online to see if it has any safety ...
0
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0answers
27 views
Is metamizole associated with rebound headaches?
I can't find any specific mention on the internet if Metamizole (most known as dipyrone) is specifically associated with rebound headaches like other pain relieve medications like Aspirin, ...
2
votes
1answer
79 views
If placebo controls work even when the patient is aware that the treatment is a placebo. Why are deceptive placebo controls used?
Placebos are “fake” treatments prescribed for the psychological benefit to the patient rather than for any physiological effect. Placebos are used for conditions defined by “self-observation” symptoms ...
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0answers
26 views
Tick bite treatment. Doxycycline intake suspended after 3 days only. If substituted by Bactrim, is there a risk to develop bacteria resistant?
A patient was bitten by a tick and carried the tick on his skin for 5/6 days (which got engorged at the end).
Then the tick dropped spontaneously.
He has been prescribed a preventive antibiotic course ...
1
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1answer
50 views
Why are some medicines recommended to be taken with a high dose and low frequency?
Alendronate sodium is an osteoporosis medicine commonly recommended
as a once-a-week 70 mg dose.
Why not 35 mg twice a week? or 10 mg daily? I am guessing that a more
steady intake like this would be ...
0
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2answers
46 views
Book of drug interactions
Where can I find full list of drug _ drug interaction & adverse reaction, apart from pdr.net, I mean to say in a book form. What books of medical science contain these information? Please name a ...
0
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1answer
50 views
interaction between Mirtazapine & Mesalamine & olanzapine [closed]
Is there any adverse reaction or interaction between Mirtazapine & Mesalamine & olanzapine, If taken in low doses(mirtazapine 7.5 & Olanzapine 2.5).
3
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1answer
54 views
Why is methadone not prescribed with naloxone for opioid use disorder?
Two possible treatments for opioid use disorder are methadone or buprenorphine/naloxone (suboxone).
According to the National Alliance of Mental Illness(https://www.nami.org/About-Mental-Illness/...
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0answers
24 views
Where can I find a list (even if only partial) of excipients that cause a medication to be indivisible?
Certain tablet formulations should not be divided or halved because the tablets are film-coated for low pH resistance (i.e. for safe passage in the stomach) or because the active ingredient is not ...
1
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1answer
54 views
Are antibiotics the only class of drugs whose effectiveness reduces over time?
The phenomenon of antibiotic resistance is well known: an antibiotic is effective when first introduced to the market, but over the years, its effectiveness decreases as resistant strains of bacteria ...
3
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1answer
70 views
Why do corticosteroids have few kidney-related side effects?
Prostaglandins are involved with promoting various renal functions. Therefore, NSAIDs, like indomethacin which inhibits protaglandin formation through COX enzyme inhibition, tend to have many side-...
3
votes
1answer
141 views
Why is prothrombin time used to monitor warfarin and not aPTT?
Warfarin is said to change prothrombin time (PT) but not activated partial thromboplastin time (aPTT) (for practical purposes at least anyways, not really sure). But looking at the mechanism of action ...
1
vote
1answer
56 views
Is it useless to drip Vitamin D drops on your tongue? [closed]
One celebrity doctor in my country says that Vitamin D can be absorbed only in the small intestine and that dropping Vitamin D drops on your tongue is therefore useless, because most of the liquid ...
0
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0answers
23 views
Have any conclusions been made regarding the interaction of Covid-19 and ACE inhibitor medications? [duplicate]
About two months ago, I started to see articles appear regarding the potential interactions between ACE inhibitor medications (commonly used to treat high blood pressure) and the severity of Covid-19
...
2
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0answers
46 views
What exactly is the meaning of “No doping” sign on a drug package?
I noticed a "No doping" sign on the back of a pack of Dopamine HCl ampoules. It looks like this:
I was wondering what is the purpose of this sign. I am guessing that it means that the drug should not ...
1
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1answer
31 views
Prevent-Release Systems for Opioid Painkillers Vs Placebo
today we were studying oral novel drug delivery systems. The class was prerecorded (due to pandemic) There was this table in the slides "strategies and benefits of modifying drug release table" and I ...
7
votes
5answers
298 views
Does Ivermectin treat COVID-19 coronavirus infection?
Does the anti-parasitic Ivermectin work in actual human studies versus the Petri dish in vitro studies, when treating coronavirus COVID-19 infection? And if so, is it safe in humans?
An in vitro ...
8
votes
1answer
252 views
How is Lopinavir + Ritonavir expected to stop COVID-19?
There are four drugs being tested for effectiveness against COVID-19 in the SOLIDARITY trial. Three of them have obvious potential mechanisms of action:
Remdesivir is an RNA polymerase inhibitor. ...
2
votes
1answer
60 views
Why are multiple courses of isotretinoin necessary to treat acne?
The following guidances don't detail why multiple courses are more efficacious?
Aug 21 2019 PRODUCT MONOGRAPH on Accutane, Hoffmann-La Roche Limited, p. 13 of 36.
Effects of multiple courses of ...
1
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2answers
112 views
What are the special medications to treat Covid-19?
We know there is no cure for Covid-19 (currently) and the
treatment focuses on managing symptoms as the virus runs its course.
The main symptoms of Covid-19 are
-Fever
-Cough
-Shortness of breath
...
2
votes
1answer
71 views
ACE2 Inhibition as therapeutic candidate?
Disclaimer: I am a scientist, but this is not my main field so sorry if I've not used the correct terminology at this busy time...
Since the coronavirus protein bonds with and gains entry to the cell ...
7
votes
4answers
125 views
Are there any central trackers for COVID-19 trials?
There are several aggregate central trackers for the spread of COVID-19. Like this one, for example.
Is there anything similar for trials? Or trials in the pipeline? Either vaccines or treatments?
