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Questions tagged [mechanism-of-action]

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How does the “leucovorin rescue” work exactly? Why doesn't it make cancerous tumours grow?

Folinic acid is used to counteract methotrexate toxicity in cancer patients. But why exactly doesn't it counteract methotrexate's therapeutic effects? Why doesn't this "leucovorin rescue" make tumors ...
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Where does Ibuprofen inhibit COX-1, and what is its MoA?

Both ASA and Ibuprofen are COX-1 inhibitors. However, ASA inhibits the formation of the enzyme Thromboxan A2 through inhibition of COX-1 at SER 529, which is responsible for thrombocytes. That in turn ...
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Demodex control with antibiotics: why and how?

Wikipedia says: Demodex folliculorum is a microscopic mite that can only survive on the skin of people. Most people have D. folliculorum on their skin. Usually, the mites do not cause any harm, ...