Questions tagged [mechanism-of-action]

Mechanism of action refers to the biochemical interaction by which a drug produces its pharmacological effect.

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“Mechanism of Action” (MOA) of medical drugs

I heard today from a doctor that the MOA for most drugs is actually 'unknown'! Wow, can this be true? I skimmed thru a pharmacology book, it looked pretty convincing but ultimately but didn't state ...
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Why can't one overdose on zinc by eating zinc-rich food such as oysters?

I've come across the following statement: Although some foods contain zinc well above the UL of 40 mg per day, no cases of zinc poisoning from naturally occurring zinc in food have been reported. ...
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How does the “leucovorin rescue” work exactly? Why doesn't it make cancerous tumours grow?

Folinic acid is used to counteract methotrexate toxicity in cancer patients. But why exactly doesn't it counteract methotrexate's therapeutic effects? Why doesn't this "leucovorin rescue" make tumors ...
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Where does Ibuprofen inhibit COX-1, and what is its MoA?

Both ASA and Ibuprofen are COX-1 inhibitors. However, ASA inhibits the formation of the enzyme Thromboxan A2 through inhibition of COX-1 at SER 529, which is responsible for thrombocytes. That in turn ...
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Demodex control with antibiotics: why and how?

Wikipedia says: Demodex folliculorum is a microscopic mite that can only survive on the skin of people. Most people have D. folliculorum on their skin. Usually, the mites do not cause any harm, ...