Questions tagged [mechanism-of-action]

Mechanism of action refers to the biochemical interaction by which a drug produces its pharmacological effect.

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4
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1answer
42 views

How does amiloride increase calcium reabsorption in the kidneys?

Amiloride is a potassium-sparing diuretic that acts on the distal convoluted tubule and collecting ducts to inhibit ENaC channels. I found studies that show that this drug increases calcium ...
7
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1answer
229 views

How is Lopinavir + Ritonavir expected to stop COVID-19?

There are four drugs being tested for effectiveness against COVID-19 in the SOLIDARITY trial. Three of them have obvious potential mechanisms of action: Remdesivir is an RNA polymerase inhibitor. ...
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“Mechanism of Action” (MOA) of medical drugs

I heard today from a doctor that the MOA for most drugs is actually 'unknown'! Wow, can this be true? I skimmed thru a pharmacology book, it looked pretty convincing but ultimately but didn't state ...
2
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0answers
446 views

Why can't one overdose on zinc by eating zinc-rich food such as oysters?

I've come across the following statement: Although some foods contain zinc well above the UL of 40 mg per day, no cases of zinc poisoning from naturally occurring zinc in food have been reported. ...
6
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1answer
181 views

How does the “leucovorin rescue” work exactly? Why doesn't it make cancerous tumours grow?

Folinic acid is used to counteract methotrexate toxicity in cancer patients. But why exactly doesn't it counteract methotrexate's therapeutic effects? Why doesn't this "leucovorin rescue" make tumors ...
6
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1answer
222 views

Where does Ibuprofen inhibit COX-1, and what is its MoA?

Both ASA and Ibuprofen are COX-1 inhibitors. However, ASA inhibits the formation of the enzyme Thromboxan A2 through inhibition of COX-1 at SER 529, which is responsible for thrombocytes. That in turn ...
5
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1answer
207 views

Demodex control with antibiotics: why and how?

Wikipedia says: Demodex folliculorum is a microscopic mite that can only survive on the skin of people. Most people have D. folliculorum on their skin. Usually, the mites do not cause any harm, ...
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2answers
4k views

What is the mechanism by which paracetamol improves sleep?

45+ old male sleep maintenance issues for couple of years resolved by fixing the basics- blacked out room, avoiding alcohol and coffee having the biggest effect. Still even if I am able to sleep 8 ...
13
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1answer
278 views

Are there any untoward synergistic effects in taking a combination of acetaminophen plus ibuprofen?

A number of years ago, it became popular to advocate a combination of acetaminophen and ibuprofen (or other non-steroidal anti-inflammatory medication) at the usual higher doses — e.g., 1,000 mg ...