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2 votes
1 answer
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Meaning of "Depletion of methyl-donor pool glycine, serine, and histidine" in a review article

From a review titled Cerebral Folate Deficiency Syndrome: Early Diagnosis, Intervention and Treatment Strategies, from Table 1: V. Conditions affecting folate metabolism in the brain Hereditary ...
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7 votes
1 answer
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Can autoantibodies found in the father affect the embryo, and how?

From "Folate Receptor Alpha Autoantibodies in Autism Spectrum Disorders: Diagnosis, Treatment and Prevention" (2021): Comparison of the Childhood Autism Rating Scale (CARS) after 2 years of ...
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1 vote
0 answers
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Dose of folinic acid/5MTHF equivalent to 400 mcg folic acid?

We know that the recommended daily dose of folic acid is 400 mcg/day. What would be the equivalent daily doses of folinic acid and of 5MTHF, if a person would decide to substitute folic acid with them?...
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1 vote
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Meaning of "over-utilisation/degradation defects such as L-dopa methylation and neurodegeneration"

In Cerebral folate deficiency: Analytical tests and differential diagnosis, I came across a tough phrase: Neurological disease was first linked to folate deficiency by Pincus and co-workers in ...
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6 votes
1 answer
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How does the "leucovorin rescue" work exactly? Why doesn't it make cancerous tumours grow?

Folinic acid is used to counteract methotrexate toxicity in cancer patients. But why exactly doesn't it counteract methotrexate's therapeutic effects? Why doesn't this "leucovorin rescue" make tumors ...
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