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Questions tagged [drug-tolerance]

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10 votes
1 answer
120 views

How serious is the antibiotic resistance problem?

I found figures and numbers on CDC and WHO, while the general public may have little idea about those numbers, such as how many people "normally" die from such disease. Can anyone provide some easy-...
Ryan's user avatar
  • 229
8 votes
1 answer
4k views

Does Benadryl (=diphenhydramine) lead to tolerance? Can I use it to help with sleep?

I am an insomniac and all the sleep medications that I've been prescribed have eventually had no effect on me -- I built a tolerance to them. It's a dangerous thing because I don't want to take lots ...
Pills N Pillows's user avatar
6 votes
1 answer
141 views

Is Moderated Caffeine Good? (if so how much and how often)

I have never engaged in caffeine except in rare circumstance where I take Excedrin due to a headache/migraine. However, after reading about the enhanced mental state from caffeine and trying a cup of ...
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4 votes
1 answer
103 views

Can early exposure to stimulates, like ritalin, result in higher tolerance to them?

As a child I was diagnosed with ADD and put on Ritalin from a young age. As a child I use to have significant insomnia, but did not realize it was due to Ritalin until I finally stopped taking it ...
dsollen's user avatar
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4 votes
1 answer
62 views

Caffeine tolerance [duplicate]

I've noticed that the consumption of caffeine increases my productivity and improves my mood. That being said, I'm wary of acquiring a tolerance - I would like to take a low enough dose infrequently ...
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4 votes
1 answer
288 views

Does tolerance develop to medicinal use of dextroamphetamine?

Dextromphetamine is used long-term to treat ADHD. Does the agent's effectiveness in treating the disorder decrease with time? Do the mood elevating properities of the drug attenuate?
user avatar
2 votes
0 answers
75 views

What benzodiazepine least causes physical dependence?

Benzodiazepines are drugs that cause physical dependence, so much that there is a movement critical to using them. Some benzodiazepines have been labled "short term" such as brotizolam, ...
somo's user avatar
  • 29
2 votes
0 answers
40 views

Heart Rate response to beta-blockers in elderly vs adults [closed]

Beta-blockers act by decreasing the heart rate of the patient. Why is this response decreased in the elderly?
Jonathan Smith's user avatar
1 vote
1 answer
61 views

How much caffeine intake a day is still safe for health?

My question is: how much mg of caffeine (as found for example in Nescafe) consumed per day is still considered safe for health? When taken in excessive amounts what can be the harmful effects? Are ...
Sonevol's user avatar
  • 111
1 vote
0 answers
30 views

Study about beliefs overriding drug effect

Now placebo is one thing that is documented and proven. However, I came across the following which claims that our beliefs can override drug effect: One researcher in this field, Dr. Henry Beecher ...
Viktor's user avatar
  • 11
1 vote
0 answers
132 views

Does a higher IQ influence the 'high' of weed?

I'm not sure if this is the best place for the question, but it seemed like the appropriate board to ask on.. So, I'm not asking if Higher IQ= Smoking more weed or anything like that. I was just ...
Attractivetoaster's user avatar
1 vote
0 answers
40 views

What is the mechanism of acute caffeine tolerance?

I'll admit this curiosity is based on a personal experience I'll document here, but I do believe it's an interesting and useful academic question to study and explore. For a while, I've noticed that ...
TheEnvironmentalist's user avatar
1 vote
0 answers
649 views

Possible to build a tolerance for the sleep hormone melatonin?

Good evening again, everybody! As my backstory goes, I am an insomniac (why you get so many questions from me). I am so fatigued, but no matter what, I just can't fall asleep... I've tried ...
Pills N Pillows's user avatar
1 vote
0 answers
104 views

Is there a limit to nicotine tolerance?

Is there a limit to how much of a nicotine tolerance you can have, or does it endlessly go on and get stronger? Edit: What I mean is whether or not there is a point to the human nicotine tolerance, ...
D. Ataro's user avatar
0 votes
0 answers
24 views

Do quick-release drugs increase physiological dependence?

I'm aware that quick-release drugs are more addictive in that they have a stronger psychological habit-forming effect, but assuming that the dose is kept constant, what effect does using a quicker-...
Zaz's user avatar
  • 340
-1 votes
1 answer
84 views

Higher doses of a drug being less effective?

Does body possibly have mechanisms for blocking drugs at higher doses and making them less effective?
asmani's user avatar
  • 425