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Questions tagged [drug-tolerance]

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How much caffeine intake a day is still safe for health?

My question is: how much mg of caffeine (as found for example in Nescafe) consumed per day is still considered safe for health? When taken in excessive amounts what can be the harmful effects? Are ...
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Are long term(off label) sleep aids less prone to tolereance and withdrawals?

Seroquel(off label) and antidepressents(offlabel remeron/elavil) have become popular for sleep. Compared to Ambien(on label drugs for sleep) is there any evidence this drugs promote less tolerance ...
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Does a higher IQ influence the 'high' of weed?

I'm not sure if this is the best place for the question, but it seemed like the appropriate board to ask on.. So, I'm not asking if Higher IQ= Smoking more weed or anything like that. I was just ...
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0answers
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What is the mechanism of acute caffeine tolerance?

I'll admit this curiosity is based on a personal experience I'll document here, but I do believe it's an interesting and useful academic question to study and explore. For a while, I've noticed that ...
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1answer
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Higher doses of a drug being less effective?

Does body possibly have mechanisms for blocking drugs at higher doses and making them less effective?
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0answers
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Heart Rate response to beta-blockers in elderly vs adults [closed]

Beta-blockers act by decreasing the heart rate of the patient. Why is this response decreased in the elderly?
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1answer
48 views

Is Moderated Caffeine Good? (if so how much and how often)

I have never engaged in caffeine except in rare circumstance where I take Excedrin due to a headache/migraine. However, after reading about the enhanced mental state from caffeine and trying a cup of ...
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1answer
48 views

Caffeine tolerance [duplicate]

I've noticed that the consumption of caffeine increases my productivity and improves my mood. That being said, I'm wary of acquiring a tolerance - I would like to take a low enough dose infrequently ...
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1answer
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How serious is the antibiotic resistance problem?

I found figures and numbers on CDC and WHO, while the general public may have little idea about those numbers, such as how many people "normally" die from such disease. Can anyone provide some easy-...
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240 views

Possible to build a tolerance for the sleep hormone melatonin?

Good evening again, everybody! As my backstory goes, I am an insomniac (why you get so many questions from me). I am so fatigued, but no matter what, I just can't fall asleep... I've tried ...
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0answers
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Is there a limit to nicotine tolerance?

Is there a limit to how much of a nicotine tolerance you can have, or does it endlessly go on and get stronger? Edit: What I mean is whether or not there is a point to the human nicotine tolerance, ...
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1answer
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Does Benadryl (=diphenhydramine) lead to tolerance? Can I use it to help with sleep?

I am an insomniac and all the sleep medications that I've been prescribed have eventually had no effect on me -- I built a tolerance to them. It's a dangerous thing because I don't want to take lots ...
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1answer
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Can early exposure to stimulates, like ritalin, result in higher tolerance to them?

As a child I was diagnosed with ADD and put on Ritalin from a young age. As a child I use to have significant insomnia, but did not realize it was due to Ritalin until I finally stopped taking it ...
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1answer
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Does tolerance develop to medicinal use of dextroamphetamine?

Dextromphetamine is used long-term to treat ADHD. Does the agent's effectiveness in treating the disorder decrease with time? Do the mood elevating properities of the drug attenuate?