Questions tagged [drug-metabolism]

Anything regarding the absorption, break down to inactive or active metabolites, distribution, and elimination of the drug through the body.

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Any drug in which the withdrawal is fatal and thus requires regular consumption (after the first dose)?

Is there any drug/medicine which once assumed forces you to take regular doses to avoid death? In example a light version of that should be insulin (Probably I'm mistaken, but I've read that taking ...
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Term for non-exposure-related tolerance?

"Tolerance" to a drug is typically interpreted to mean the state of requiring more of that drug to cause the same effects as compared to another individual, regardless of cause. However, the medical ...
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Why are thiopurine metabolites measured in units of pmol/8×10^8 RBCs?

Thioguanine nucleotides (6-TGN) and methylmercaptopurine (MeMP) are two important metabolites of thiopurine medications such as mercaptopurine (6MP) and azathioprine. The laboratory tests for these ...
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Is drug-based liver damage usually traceable to free radical generation?

From my fairly limited understanding, much of the time medications are said to be damaging to the liver, what is meant is that the process of breaking them down causes the formation of free radicals, ...
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Codeine vs Morphine competition for UGT2B7 and CYP3A4

Codeine and morphine are metabolized by the same key enzymes UGT2B7 and CYP3A4. Obviously codeine and morphine should inhibit each other's metabolism. Did anyone experimentally measure this ...
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Does broccoli interfere with CYP3A4 metabolism?

There are many articles on the effects of the active ingredients in Broccoli but I have yet to find the "smoking gun" on this question. I know grapefruit is a big offender in blocking CYP3A4 but I am ...
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28 views

What is the mechanism of acute caffeine tolerance?

I'll admit this curiosity is based on a personal experience I'll document here, but I do believe it's an interesting and useful academic question to study and explore. For a while, I've noticed that ...
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39 views

Raspberry Ketone Dietary Supplement? Fat-burning? Legit?

So I found (not expired or opened) a bottle of dietary supplements in my cabinet called "Ketone Raspberry" and it claims to "promote body fat reduction", "support increased metabolism," and "PROMOTE ...