Questions tagged [drug-metabolism]

Anything regarding the absorption, break down to inactive or active metabolites, distribution, and elimination of the drug through the body.

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Any drug in which the withdrawal is fatal and thus requires regular consumption (after the first dose)?

Is there any drug/medicine which once assumed forces you to take regular doses to avoid death? In example a light version of that should be insulin (Probably I'm mistaken, but I've read that taking ...
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Term for non-exposure-related tolerance?

"Tolerance" to a drug is typically interpreted to mean the state of requiring more of that drug to cause the same effects as compared to another individual, regardless of cause. However, the medical ...
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Why are thiopurine metabolites measured in units of pmol/8×10^8 RBCs?

Thioguanine nucleotides (6-TGN) and methylmercaptopurine (MeMP) are two important metabolites of thiopurine medications such as mercaptopurine (6MP) and azathioprine. The laboratory tests for these ...
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Is drug-based liver damage usually traceable to free radical generation?

From my fairly limited understanding, much of the time medications are said to be damaging to the liver, what is meant is that the process of breaking them down causes the formation of free radicals, ...
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Does broccoli interfere with CYP3A4 metabolism?

There are many articles on the effects of the active ingredients in Broccoli but I have yet to find the "smoking gun" on this question. I know grapefruit is a big offender in blocking CYP3A4 but I am ...
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What is the mechanism of acute caffeine tolerance?

I'll admit this curiosity is based on a personal experience I'll document here, but I do believe it's an interesting and useful academic question to study and explore. For a while, I've noticed that ...
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Raspberry Ketone Dietary Supplement? Fat-burning? Legit?

So I found (not expired or opened) a bottle of dietary supplements in my cabinet called "Ketone Raspberry" and it claims to "promote body fat reduction", "support increased metabolism," and "PROMOTE ...
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What are the main problems with non-injectable ways to administer molecules into the human body?

From past reading in various sources there seems to me to be many ways to administer molecules into the human body without injections that cause tissue trauma but that these ways generally aren't ...