Questions tagged [drug-metabolism]

Anything regarding the absorption, break down to inactive or active metabolites, distribution, and elimination of the drug through the body.

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what is the advantages (for patients) in delayed and extended release drugs?

What are the advantages for patients between extended and delayed release drugs? i understand the difference between these two drugs, but i want to know the advantages to the patients itself between ...
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78 views

“Mechanism of Action” (MOA) of medical drugs

I heard today from a doctor that the MOA for most drugs is actually 'unknown'! Wow, can this be true? I skimmed thru a pharmacology book, it looked pretty convincing but ultimately but didn't state ...
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What properties of a topical medication determine what percent is systemically absorbed (bioavailability)?

Some medications are applied topically for a local skin effect, such as: Topical corticosteroids for eczema or psoriasis, of which approx 2% is absorbed systemically. Topical tretinoin for acne, of ...
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Are vitamin C and desloratadine better absorbed when taken shortly after eating?

I'm taking vitamin C supplements and desloratadine for my allergies. I've heard some people saying that it's better to take your medicines right after eating because your body absorbs them better ...
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Why are thiopurine metabolites measured in units of pmol/8×10^8 RBCs?

Thioguanine nucleotides (6-TGN) and methylmercaptopurine (MeMP) are two important metabolites of thiopurine medications such as mercaptopurine (6MP) and azathioprine. The laboratory tests for these ...
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1answer
95 views

Dextroamphetamine vs Dextroamphetamine Salt Combo

Important: I've already consulted my doctor and am not seeking medical advice. I'm just curious here. I've been prescribed and have taken Dextroamphetamine for some time (round orange pill). Recently ...
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1answer
32 views

Caffeine clearance range/distribution and what determines it

A Sci. Am. article mentioned that Some people's bodies clear caffeine within a few hours, but lunchtime coffee may still be in the system of other people even late at night. Although they have ...
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1answer
160 views

Where does Ibuprofen inhibit COX-1, and what is its MoA?

Both ASA and Ibuprofen are COX-1 inhibitors. However, ASA inhibits the formation of the enzyme Thromboxan A2 through inhibition of COX-1 at SER 529, which is responsible for thrombocytes. That in turn ...
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What is the mechanism of acute caffeine tolerance?

I'll admit this curiosity is based on a personal experience I'll document here, but I do believe it's an interesting and useful academic question to study and explore. For a while, I've noticed that ...
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73 views

Higher doses of a drug being less effective?

Does body possibly have mechanisms for blocking drugs at higher doses and making them less effective?
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4k views

Is it safe to drink Monster Energy (or any energy drink) after paracetamol? [closed]

I took two tablets about an hour ago and now would like to drink an energy drink to give me a boost. I've been told this is potentially unsafe. Is there any dangers to this?
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Is drug-based liver damage usually traceable to free radical generation?

From my fairly limited understanding, much of the time medications are said to be damaging to the liver, what is meant is that the process of breaking them down causes the formation of free radicals, ...
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284 views

Why is thalidomide a current drug on the market?

Given the thalidomide birth defect disaster of the 1960s, why was it later approved by the U.S. FDA for treatment of leprosy (1996) and of multiple myeloma (2006)? Presumably, the teratogenic issues ...
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5k views

Urine analysis, the baking soda myth

So there is a remedy floating around the internet that states 1 tblspn of baking soda mixed in 8 oz of water results in forced excretion of water soluble drugs. For example methamphetamine. I'm not ...
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1answer
1k views

Does the rate of ethanol absorption into blood stream slow down as you drink more?

My coworker and I were having a discussion over the rate of alcohol absorption. He argued that after you reach x number of drinks, your body stops passing as much ethanol into the bloodstream because ...
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312 views

Why some people experience no side effects from a drug?

NOTE: Please, do not refer to the article it has been given as an arbitrary introduction to the question I've stumbled upon an article daily heroin usage for 20 years. Basically, the article is ...
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1answer
43 views

Risks of Caffeine Powder

I'm genetically predisposed to early onset osteoporosis, so I'm trying to cut back on acids in my diet. Coffee is a big one, but I'm also still in school so I'm very attached to caffeine. Would ...
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Raspberry Ketone Dietary Supplement? Fat-burning? Legit?

So I found (not expired or opened) a bottle of dietary supplements in my cabinet called "Ketone Raspberry" and it claims to "promote body fat reduction", "support increased metabolism," and "PROMOTE ...
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0answers
76 views

Any drug in which the withdrawal is fatal and thus requires regular consumption (after the first dose)?

Is there any drug/medicine which once assumed forces you to take regular doses to avoid death? In example a light version of that should be insulin (Probably I'm mistaken, but I've read that taking ...
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1answer
35 views

Why isn't clorhexidine gluconate used among humans?

It is used for non-human animals, but as far as I have read it is not used among people. Are there exceptions?
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28k views

How long should I wait to drive after taking a painkiller?

Recently, I was prescribed hydrocodone. Part of the instructions I was given (on the label, from the physician, and from the pharmacist) included not to drive while taking the medication. However, it ...
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0answers
23 views

Term for non-exposure-related tolerance?

"Tolerance" to a drug is typically interpreted to mean the state of requiring more of that drug to cause the same effects as compared to another individual, regardless of cause. However, the medical ...
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1answer
307 views

What effect does long-term caffeine use have on memory?

I've seen plenty of references to the same study of how caffeine benefits memory after one day of use (1) (2) (3), but what about long-term use? There are all sort of factors to long-term use such as ...
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1answer
3k views

How much T4 thyroid is equivalent to an amount of T3?

How much T4 thyroid is equivalent to an amount of T3? E.g. will x T4 generally be created to 1/2x T3?
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Why do I feel shaky after only a small amount of caffeine?

I like coffee, but caffeine seems to 'wire' me much more extremely than most other people. I feel energized or even shaky after less than half a normal cup, and a whole 8 ounces will usually cause me ...
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278 views

Can the immune system break down anything?

Every time one takes a pill, drinks a glass of wine, or uses an illicit drug, it is understood that the effects are temporary. Caffeine only keeps one awake for a few hours, alcohol only intoxicates ...