Questions tagged [covid-19]

Describes the clinical disease caused by the SARS-CoV-2 virus

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Question about more transmissible SARS-Cov-2 variants, and a “dose-response” hypothesis

More transmissible variants, such as what is being reported from Great Britain, etc. There seems to be a preliminary consensus settling on the idea that the SARS-Cov-2-variant named B.1.1.7 is far ...
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How fast could mRNA COVID manufacturers switch from the Wuhan strain to e.g. B.1.1.7 and why?

I understand that the time it took Modena to go from the SARS-CoV-2 sequence to shipping doses for clinical trial was 44 days: https://www.modernatx.com/modernas-work-potential-vaccine-against-covid-...
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Would vaccines against COVID variants (e.g. B.1.1.7) need *additional* clinical trials?

Every year, the influenza vaccine changes a little bit, incorporating different strains every year. I believe that these vaccine variants don't have to undergo clinical trials, that they piggyback on ...
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How much more protection does doubling up masks offer for COVID-19?

I have read several news articles mentioning that doubling up masks offer some additional protection for COVID-19. E.g. https://denver.cbslocal.com/2021/01/20/doubling-up-face-masks-creates-obstacle-...
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Are flu levels of covid-19 mortality rate like Singapore's obtainable by any country, or do they depend of the demographics of the people infected? [closed]

According to these articles, Study reports... Influeza The death rate of the seasonal flu is 0.1%. And according to this, Coronavirus death rates worldwide Countries like Singapore (0,05%), Mongolia (...
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What are the pitfalls using the standard vaccine effectiveness calculation process if applied to reinfectivity observations?

Phase 3 clinical trials for Covid-19 vaccines have been completed, and the "effectiveness" values have been made available. The trials involved a placebo arm, such that if the vaccine were ...
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Are “some serious side effects and deaths expected” from a mass vaccination campaign of a new vaccine?

According to What is known so far about the post vaccination deaths in Norway Medical director Steinar Madsen stated, Q: Were these problems unexpected? A: No. A mass vaccination campaign by ...
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Why does the Pfizer’s Covid vaccine cause more intense intense symptoms after second shot then after the first shot?

cnbc.com (mirror) mentions: The FDA says Pfizer’s Covid vaccine is safe and effective. But trial participants warn of intense symptoms after second shot. Why does the Pfizer’s Covid vaccine cause ...
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Covid-19 mortality rates lower among some diabetes patients

It has been found that hospitalized COVID-19 patients have a greater risk of dying if they are men or are obese or have complications from diabetes or hypertension (University of Maryland School of ...
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How does the type of syringe impact the number of doses of Corona vaccine available per vial?

In an interview with Ron Klain (Biden's Chief of Staff) on CNN this morning, it was suggested that Biden would invoke the National Defense Production act to increase the production of syringes that ...
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Is the code from the mRNA vaccine executed by the cells as a one-off? [closed]

Is the code from the mRNA vaccine executed by the cell that has taken it up as a one-off or does the cell produce the spike proteins endlessly (like a programming loop) until the cell is killed by the ...
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Why do some vectored vaccine makers rely on 1-jab only for their Covid-19 vaccines?

While some of the medical companies like AstraZeneca and Russian Gamaleya, which use a vectored approach for their Covid-19 vaccines, choose a two-jab schedule, the others like CanSino and J&J ...
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Are all ad5 vector vaccines (including COVID19 potential vaccines) really dangerous in terms of higher risk of getting HIV? [closed]

I'm currently living in a country where people can count only on ad5-vector based vaccines against Covid19 in the near future. Making up my mind about getting such jab, I came across several ...
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Could the COVID-19 vaccine adversely impact healthy protein reception?

I'm not a health expert, just trying to understand possible long-term side effects of the vaccine, so if my terminology and thinking is off, feel free to correct. The prominent vaccines right now are ...
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CDC COVID Vaccine Administration Time Series Data?

For context, in the past the CDC has published time series data of COVID case counts by State: https://healthdata.gov/dataset/united-states-covid-19-cases-and-deaths-state-over-time Now, CDC are ...
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For fighting COVID19, Why we give the body the RNA and not give the body the protien itself? [duplicate]

If I understand things correctly the popular COVID 19 vaccine gives the body RNA that teaches the body cells to create a protein that looks like the virus. And then the body learns to fight against it....
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How can “new viruses” exist? [closed]

Background: I have no background in medical sciences, and this is something I've been thinking about since the start of the Covid-19 pandemic; please ELI5 your answer if you can. Thanks! We estimate ...
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Which regimen of the AstraZeneca vaccine was approved (in UK and India respectively)?

The Oxford-AstraZeneca made furore two months ago for a dosage error in its 3rd phase trial. The 3000 or so trial participant who got the regimen with the erroneous dosage, showed apparent greater ...
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COVID 19 Vaccine Portfolio Allocation

Given a US population of 330 million people and n number of COVID 19 vaccines. What is the line of thinking to decide: How many total number of people to be vaccinated? After deciding the total ...
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BNT162b2 mRNA Covid-19 Vaccine efficacy after 1st dose - explain the statistics

Pfizer's paper (Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine) published recently states the following in the Efficacy subsection of the Results section: Between the first dose and the ...
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(Why) doesn't Moderna's Covid vaccine have an INN?

Pfizer's and even more obscure mRNA vaccines that haven't been approved have an INN, which ends with -meran (e.g. CureVac's is "zorecimeran"). But as far as I can tell Moderna's vaccine ...
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Why do adults need vaccination boosters? [duplicate]

In the UK at the moment there's some controversy regarding the changing of the timing of the Covid vaccination boosters. All the vaccines I can think of that need boosters are given to babies, whose ...
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Why isn't the mRNA in covid-19 vaccines taken up by all types of cells?

I'm familiar with the basic principles by which the moderna/pfizer vaccines work. I'm confused about how the vaccines are able to make sure that mRNA is only taken up by dendritic cells. If mRNA is ...
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Will the COVID-19 vaccine grant immunity to other coronaviruses?

As I understand it, the mRNA vaccine teaches the immune system to recognize and attack the spike protein on the surface of the novel coronavirus. Don't all coronaviruses share this same spike protein? ...
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Is there a benefit of a COVID-19 vaccination if one had COVID-19 before?

I see the clear benefit of the vaccination if one didn't have the disease. However, there are a lot of people who had the disease already. So I assume they also have the anti-bodies? Or is this a ...
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Why Herpes Vaccine Hasn't Been Discovered Yet While Corona Vaccines Find Its Way Within A Year? [closed]

There is one question constantly running in my mind: how were COVID-19 vaccines discovered in a very short time span, but Herpes did not find its way even after years of painstaking research?
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Are there any educated guesses related to the type and probability of severe side effects caused by the COVID-19 vaccines?

Multiple countries have already started the COVID-19 vaccination. Local media covered this extensively and I saw that many medical doctors and researchers arguing that the vaccines are very safe ...
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Why does the Pfizer vaccine need storage at -70C but Moderna's only needs -20C, when they are both mRNA vaccines?

It's been widely reported in the press that Pfizer's vaccine needs storage at -70C but Moderna's only needs -20C. Why is this so, when they are both mRNA vaccines? There's actually a looong article in ...
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How do mRNA vaccines work and what are their advantages over traditional vaccines?

How do mRNA vaccines work? To my intuitive understanding, for an mRNA vaccine to work, the mRNAs injected into the patient need to first enter a cell and get translated into proteins. Those proteins ...
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How can we realistically vaccinate our way to herd immunity?

So I've been keeping track of the number of people have received a vaccine for COVID-19 in the US. If we want to vaccinate 70%-90% of the population, per latest Dr. Fauci's estimates, then we need to ...
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Can Nintedanib, Pirfenidone medicine be used to prevent lung fibrosis when the patient is on ECMO? [closed]

He has Sepsis,DKA ,ARDS,Infection, Glycemia. Any alternative medication?
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Don't mRNA vaccines (Pfizer and Moderna) cure COVID patients? [closed]

I went through the below Twitter thread on how mRNA vaccines (Pfizer and Moderna) work. https://twitter.com/WheatNOil/status/1339624815137722368 As per that, these vaccines prepare our body to fight ...
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Details on “Health Impact Events” on V-safe Active Surveillance for COVID-19 Vaccines

Some dubious websites (which I won't link) are claiming that COVID-19 vaccine caused disabilities in more than 3.000 people. As a support of this claim, they cite the table "V-safe Active ...
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What invention or condition made it possible for mRNA vaccines to work for COVID-19?

mRNA vaccines have been developed for over 30 years. What invention or condition made it possible for mRNA vaccines to work for COVID-19, despite the fact that they haven't been successful yet for ...
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What are some mRNA vaccines, other than COVID vaccines, that are widely used?

From what I've read, COVID vaccines belong to mRNA vaccines category. I read in the above article that mRNA vaccines act in a different way than traditional vaccines. [..]Traditional vaccines ...
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COVID-19 Variants

I have been looking at this "new variant" of the virus which causes COVID-19 and the British Medical Journal has said What do we know about this new SARS-CoV-2 variant? It’s been snappily ...
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New Covid December 2020 mutation in UK and its consequences [closed]

The new Covid December 2020 mutation in UK is believed to be 70% more contagious than the original version. Could one reason be that Airborne transmission by normal breathing is now a dominant form of ...
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How do pharmaceutical companies deal with people who received a placebo?

I would like to know what happens to the people in the vaccine studies who received a placebo. Essentially they have not been vaccinated. However, in order for the study to stay blind so that long ...
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What is resolving state after infection period?

In the paper https://web.stanford.edu/~chadj/sird-paper.pdf (p6-7), the authors define a resolving state right after the infectiousness being resolved. They claim the resolving state resolves after ...
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Solve SIR in continuous or discrete form, which one is more accurate in epidemiology sense

Oftentimes, SIR model is used in epidemiology to model infection. Based on the model form, the original SIR model is continuous, and strictly should be solved with continous ode solver. However, it ...
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How long would societal restrictions be in place if a COVID-19 vaccine has upward of 90% effectiveness? [closed]

Background Back in October, Dr. Fauci said that the United States will need societal restrictions potentially until the beginning of 2022 according to WebMD: Coronavirus vaccines -- once approved and ...
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Running during COVID Pandemic Situation? [closed]

I used to run and I enjoyed it a lot. I also practice calisthenics: push ups, pull ups, dips, etc. During this pandemic situation I have kind of stopped running, and diminished my workouts a lot (I ...
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Any replications for the finding that SARS-CoV-2 disease severity depends on the initial ineffective dose?

In an October NEJM article it was stated that: Recent virologic, epidemiologic, and ecologic data have led to the hypothesis that facial masking may also reduce the severity of disease among people ...
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How can a vaccine prevent an individual from getting a disease but not from transmitting it?

In the news about the COVID-19 vaccines which are about to begin distribution, I've seen statements to the effect that "it’s not clear if the shot keeps the disease from being transmitted" (...
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What global health organization coordinates vaccine production?

Question What, if any, global health organization coordinates global vaccine production? Context: It is in the global interest to produce qualified (safety / efficacy) COVID-19 vaccine doses as quick ...
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Covid vaccine side effects [closed]

The Pfizer Covid vaccine caused allergic reactions. For patients that are deemed to be at an increased risk of adverse side effects following a risk assessment (e.g. because of diabetes, heart disease)...
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Is there a reason to be anxious about claim that COVID-19 vaccine could turn out to be inducing infertility in females?

There is a petition written on December 1, 2020 to European Medicines Agency (EMA) by Dr. med. Wolfgang Wodarg and Dr. Michael Yeadon. You can see it here. Both of them are well known for spreading ...
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Will getting a vaccine have any additional effect on your immune system if you already got covid-19?

Supposedly people who got covid-19 get immunity after it. According to this article, More SARS-COV-2 reinfections reported but still a rare event citing several studies, Bertollini and his colleagues ...
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From R naught to infectious number [closed]

R naught is defined as number of infections from one sick person, and most of the paper when simulating the infectious number tends to directly multiply the current infectious number by R naught to ...
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Can an individual who has had a covid-19 vaccination test positive and is that a problem?

Can an individual who has had a covid-19 vaccination test positive and is that a problem? Up to now and for some time to come, testing has been important to help control the spread of this disease. ...

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